Galangin Dampens Mice Lipopolysaccharide-Induced Acute Lung Injury
Galangin, an active ingredient of Alpinia galangal , has been shown to possess anti-inflammatory and antioxidant activities. Inflammation and oxidative stress are known to play vital effect in the pathogenesis of acute lung injury (ALI). In this study, we determined whether galangin exerts lung prot...
Gespeichert in:
| Veröffentlicht in: | Inflammation 2014-10, Vol.37 (5), p.1661-1668 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1668 |
|---|---|
| container_issue | 5 |
| container_start_page | 1661 |
| container_title | Inflammation |
| container_volume | 37 |
| creator | Shu, Yu-Sheng Tao, Wei Miao, Qian-Bing Lu, Shi-Chun Zhu, Ya-Bing |
| description | Galangin, an active ingredient of
Alpinia galangal
, has been shown to possess anti-inflammatory and antioxidant activities. Inflammation and oxidative stress are known to play vital effect in the pathogenesis of acute lung injury (ALI). In this study, we determined whether galangin exerts lung protection in lipopolysaccharide (LPS)-induced ALI. Male BALB/c mice were randomized to receive galangin or vehicle intraperitoneal injection 3 h after LPS challenge. Samples were harvested 24 h post LPS administration. Galangin administration decreased biochemical parameters of oxidative stress and inflammation, and improved oxygenation and lung edema in a dose-dependent manner. These protective effects of galangin were associated with inhibition of nuclear factor (NF)-κB and upregulation of heme oxygenase (HO)-1. Galangin reduces LPS-induced ALI by inhibition of inflammation and oxidative stress. |
| doi_str_mv | 10.1007/s10753-014-9894-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1611639080</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1611639080</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-577e20cfbbb21a564acb930f6aa5aae5bbba7e7fd7d1bd772886dafeeba4a60e3</originalsourceid><addsrcrecordid>eNp1kMFOwzAMhiMEYmPwAFxQJS5cAknTNM1xDBiThrjAOXJTd3Tq2pKsh709mToQQuJkyf782_oIueTsljOm7jxnSgrKeEJ1phPKj8iYSyVoLFV6TMZMpIwKrdWInHm_ZoxlOhOnZBQnKhGa6zG5n0MNzapqogfYdNj46KWyGC2rru3aeufB2g9wVYF00RS9xSKa2n4bgL5ZRYtm3bvdOTkpofZ4cagT8v70-DZ7psvX-WI2XVKbKLmlUimMmS3zPI85yDQBm2vByhRAAqAMfVCoykIVPC-UirMsLaBEzCGBlKGYkJsht3PtZ49-azaVt1iH_7HtveEp56nQLGMBvf6DrtveNeE7w8NloWKV6UDxgbKu9d5haTpXbcDtDGdmL9gMgk0QbPaCDQ87V4fkPt9g8bPxbTQA8QD4MGpW6H6d_jf1C2jJhjs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1564372789</pqid></control><display><type>article</type><title>Galangin Dampens Mice Lipopolysaccharide-Induced Acute Lung Injury</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Shu, Yu-Sheng ; Tao, Wei ; Miao, Qian-Bing ; Lu, Shi-Chun ; Zhu, Ya-Bing</creator><creatorcontrib>Shu, Yu-Sheng ; Tao, Wei ; Miao, Qian-Bing ; Lu, Shi-Chun ; Zhu, Ya-Bing</creatorcontrib><description>Galangin, an active ingredient of
Alpinia galangal
, has been shown to possess anti-inflammatory and antioxidant activities. Inflammation and oxidative stress are known to play vital effect in the pathogenesis of acute lung injury (ALI). In this study, we determined whether galangin exerts lung protection in lipopolysaccharide (LPS)-induced ALI. Male BALB/c mice were randomized to receive galangin or vehicle intraperitoneal injection 3 h after LPS challenge. Samples were harvested 24 h post LPS administration. Galangin administration decreased biochemical parameters of oxidative stress and inflammation, and improved oxygenation and lung edema in a dose-dependent manner. These protective effects of galangin were associated with inhibition of nuclear factor (NF)-κB and upregulation of heme oxygenase (HO)-1. Galangin reduces LPS-induced ALI by inhibition of inflammation and oxidative stress.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-014-9894-1</identifier><identifier>PMID: 24743919</identifier><identifier>CODEN: INFLD4</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Acute Lung Injury - chemically induced ; Acute Lung Injury - metabolism ; Acute Lung Injury - prevention & control ; Alpinia ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Flavonoids - pharmacology ; Flavonoids - therapeutic use ; Immunology ; Inflammation Mediators - antagonists & inhibitors ; Inflammation Mediators - metabolism ; Internal Medicine ; Lipopolysaccharides - antagonists & inhibitors ; Lipopolysaccharides - toxicity ; Male ; Mice ; Mice, Inbred BALB C ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Pathology ; Pharmacology/Toxicology ; Rheumatology</subject><ispartof>Inflammation, 2014-10, Vol.37 (5), p.1661-1668</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-577e20cfbbb21a564acb930f6aa5aae5bbba7e7fd7d1bd772886dafeeba4a60e3</citedby><cites>FETCH-LOGICAL-c475t-577e20cfbbb21a564acb930f6aa5aae5bbba7e7fd7d1bd772886dafeeba4a60e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-014-9894-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-014-9894-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24743919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shu, Yu-Sheng</creatorcontrib><creatorcontrib>Tao, Wei</creatorcontrib><creatorcontrib>Miao, Qian-Bing</creatorcontrib><creatorcontrib>Lu, Shi-Chun</creatorcontrib><creatorcontrib>Zhu, Ya-Bing</creatorcontrib><title>Galangin Dampens Mice Lipopolysaccharide-Induced Acute Lung Injury</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Galangin, an active ingredient of
Alpinia galangal
, has been shown to possess anti-inflammatory and antioxidant activities. Inflammation and oxidative stress are known to play vital effect in the pathogenesis of acute lung injury (ALI). In this study, we determined whether galangin exerts lung protection in lipopolysaccharide (LPS)-induced ALI. Male BALB/c mice were randomized to receive galangin or vehicle intraperitoneal injection 3 h after LPS challenge. Samples were harvested 24 h post LPS administration. Galangin administration decreased biochemical parameters of oxidative stress and inflammation, and improved oxygenation and lung edema in a dose-dependent manner. These protective effects of galangin were associated with inhibition of nuclear factor (NF)-κB and upregulation of heme oxygenase (HO)-1. Galangin reduces LPS-induced ALI by inhibition of inflammation and oxidative stress.</description><subject>Acute Lung Injury - chemically induced</subject><subject>Acute Lung Injury - metabolism</subject><subject>Acute Lung Injury - prevention & control</subject><subject>Alpinia</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Flavonoids - pharmacology</subject><subject>Flavonoids - therapeutic use</subject><subject>Immunology</subject><subject>Inflammation Mediators - antagonists & inhibitors</subject><subject>Inflammation Mediators - metabolism</subject><subject>Internal Medicine</subject><subject>Lipopolysaccharides - antagonists & inhibitors</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Rheumatology</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kMFOwzAMhiMEYmPwAFxQJS5cAknTNM1xDBiThrjAOXJTd3Tq2pKsh709mToQQuJkyf782_oIueTsljOm7jxnSgrKeEJ1phPKj8iYSyVoLFV6TMZMpIwKrdWInHm_ZoxlOhOnZBQnKhGa6zG5n0MNzapqogfYdNj46KWyGC2rru3aeufB2g9wVYF00RS9xSKa2n4bgL5ZRYtm3bvdOTkpofZ4cagT8v70-DZ7psvX-WI2XVKbKLmlUimMmS3zPI85yDQBm2vByhRAAqAMfVCoykIVPC-UirMsLaBEzCGBlKGYkJsht3PtZ49-azaVt1iH_7HtveEp56nQLGMBvf6DrtveNeE7w8NloWKV6UDxgbKu9d5haTpXbcDtDGdmL9gMgk0QbPaCDQ87V4fkPt9g8bPxbTQA8QD4MGpW6H6d_jf1C2jJhjs</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Shu, Yu-Sheng</creator><creator>Tao, Wei</creator><creator>Miao, Qian-Bing</creator><creator>Lu, Shi-Chun</creator><creator>Zhu, Ya-Bing</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20141001</creationdate><title>Galangin Dampens Mice Lipopolysaccharide-Induced Acute Lung Injury</title><author>Shu, Yu-Sheng ; Tao, Wei ; Miao, Qian-Bing ; Lu, Shi-Chun ; Zhu, Ya-Bing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-577e20cfbbb21a564acb930f6aa5aae5bbba7e7fd7d1bd772886dafeeba4a60e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute Lung Injury - chemically induced</topic><topic>Acute Lung Injury - metabolism</topic><topic>Acute Lung Injury - prevention & control</topic><topic>Alpinia</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Flavonoids - pharmacology</topic><topic>Flavonoids - therapeutic use</topic><topic>Immunology</topic><topic>Inflammation Mediators - antagonists & inhibitors</topic><topic>Inflammation Mediators - metabolism</topic><topic>Internal Medicine</topic><topic>Lipopolysaccharides - antagonists & inhibitors</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>Pathology</topic><topic>Pharmacology/Toxicology</topic><topic>Rheumatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shu, Yu-Sheng</creatorcontrib><creatorcontrib>Tao, Wei</creatorcontrib><creatorcontrib>Miao, Qian-Bing</creatorcontrib><creatorcontrib>Lu, Shi-Chun</creatorcontrib><creatorcontrib>Zhu, Ya-Bing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shu, Yu-Sheng</au><au>Tao, Wei</au><au>Miao, Qian-Bing</au><au>Lu, Shi-Chun</au><au>Zhu, Ya-Bing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Galangin Dampens Mice Lipopolysaccharide-Induced Acute Lung Injury</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>37</volume><issue>5</issue><spage>1661</spage><epage>1668</epage><pages>1661-1668</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><coden>INFLD4</coden><abstract>Galangin, an active ingredient of
Alpinia galangal
, has been shown to possess anti-inflammatory and antioxidant activities. Inflammation and oxidative stress are known to play vital effect in the pathogenesis of acute lung injury (ALI). In this study, we determined whether galangin exerts lung protection in lipopolysaccharide (LPS)-induced ALI. Male BALB/c mice were randomized to receive galangin or vehicle intraperitoneal injection 3 h after LPS challenge. Samples were harvested 24 h post LPS administration. Galangin administration decreased biochemical parameters of oxidative stress and inflammation, and improved oxygenation and lung edema in a dose-dependent manner. These protective effects of galangin were associated with inhibition of nuclear factor (NF)-κB and upregulation of heme oxygenase (HO)-1. Galangin reduces LPS-induced ALI by inhibition of inflammation and oxidative stress.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24743919</pmid><doi>10.1007/s10753-014-9894-1</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3997 |
| ispartof | Inflammation, 2014-10, Vol.37 (5), p.1661-1668 |
| issn | 0360-3997 1573-2576 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1611639080 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acute Lung Injury - chemically induced Acute Lung Injury - metabolism Acute Lung Injury - prevention & control Alpinia Animals Biomedical and Life Sciences Biomedicine Flavonoids - pharmacology Flavonoids - therapeutic use Immunology Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Internal Medicine Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - toxicity Male Mice Mice, Inbred BALB C Oxidative Stress - drug effects Oxidative Stress - physiology Pathology Pharmacology/Toxicology Rheumatology |
| title | Galangin Dampens Mice Lipopolysaccharide-Induced Acute Lung Injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T19%3A23%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Galangin%20Dampens%20Mice%20Lipopolysaccharide-Induced%20Acute%20Lung%20Injury&rft.jtitle=Inflammation&rft.au=Shu,%20Yu-Sheng&rft.date=2014-10-01&rft.volume=37&rft.issue=5&rft.spage=1661&rft.epage=1668&rft.pages=1661-1668&rft.issn=0360-3997&rft.eissn=1573-2576&rft.coden=INFLD4&rft_id=info:doi/10.1007/s10753-014-9894-1&rft_dat=%3Cproquest_cross%3E1611639080%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1564372789&rft_id=info:pmid/24743919&rfr_iscdi=true |