The Effects of C-type Natriuretic Peptide on Craniofacial Skeletogenesis

C-type natriuretic peptide (CNP) is a potent stimulator of long bone and vertebral development via endochondral ossification. In the present study, we investigated the effects of CNP on craniofacial skeletogenesis, which consists of both endochondral and membranous ossification. Morphometric analyse...

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Veröffentlicht in:	Journal of dental research 2013-01, Vol.92 (1), p.58-64
Hauptverfasser:	Nakao, K., Okubo, Y., Yasoda, A., Koyama, N., Osawa, K., Isobe, Y., Kondo, E., Fujii, T., Miura, M., Bessho, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggrecans - analysis Animals Bone growth Bones C-Type natriuretic peptide Cartilage Cartilage, Articular - drug effects Cell Culture Techniques Cell Proliferation - drug effects Cephalometry - methods Chondrocytes Chondrocytes - drug effects Collagen Type II - genetics Collagen Type X - analysis Cranial Sutures - drug effects Dentistry Dose-Response Relationship, Drug Endochondral bone Experiments Facial Bones - drug effects Fetuses Imaging, Three-Dimensional - methods Jaw Long bone Mandible Mandible - drug effects Mandibular Condyle - drug effects Maxilla Maxilla - drug effects Mice Mice, Knockout Mice, Transgenic Nasal Cartilages - drug effects Natriuretic Peptide, C-Type - pharmacology Occipital Bone - drug effects Organ Culture Techniques Ossification Osteogenesis - drug effects Peptides Proliferating Cell Nuclear Antigen - analysis Rodents Septum Skeletogenesis Skull Skull - drug effects Skull Base - drug effects Sphenoid Bone - drug effects Statistical analysis Transgenic animals Transgenic mice Variance analysis Vertebrae X-Ray Microtomography - methods
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