Stand-alone ALIF with integrated intracorporeal anchoring plates in the treatment of degenerative lumbar disc disease: a prospective study on 65 cases
Purpose ALIF with cages is expected to restore disc height and stabilize the spine promoting fusion, while avoiding damage attributed to rod-pedicle screw fixation. However, it may be related to an increased risk of fusion failure and subsidence. A prospective study was conducted by five investigato...
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| Veröffentlicht in: | European spine journal 2014-10, Vol.23 (10), p.2136-2143 |
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| creator | Allain, Jérôme Delecrin, Joël Beaurain, Jacques Poignard, Alexandre Vila, Thierry Flouzat-Lachaniette, Charles-Henri |
| description | Purpose
ALIF with cages is expected to restore disc height and stabilize the spine promoting fusion, while avoiding damage attributed to rod-pedicle screw fixation. However, it may be related to an increased risk of fusion failure and subsidence. A prospective study was conducted by five investigators across three centers to confirm performance of a PEEK cage for stand-alone ALIF in the treatment of lumbar degenerative disc disease (DDD).
Methods
Sixty-five patients, with back ± leg pain, requiring surgery for DDD, were included. Efficacy and safety were evaluated at 6 weeks, 3, 6, and 12 months post-operatively. Fusion and subsidence were assessed through CT-images at 12-month follow-up. Disc height was measured. Clinical outcomes included back and leg pain (VAS), disability (Oswestry Disability Index), Quality of Life (Short-Form 36), and adverse events.
Results
The fusion and the subsidence rates were 96.3 and 2.0 %, respectively. ALIF surgery restored anterior and posterior disc height compared to baseline. There were no device-related serious adverse events, and no revision surgeries. Clinical outcomes improved significantly through 12-month follow-up.
Conclusion
Safety and efficacy of this stand-alone cage with integrated intracorporeal plates was confirmed through 12 months for treatment of degenerative conditions. The design of the cage and plates may contribute to the decreased subsidence rate observed. |
| doi_str_mv | 10.1007/s00586-014-3364-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1611635746</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1611635746</sourcerecordid><originalsourceid>FETCH-LOGICAL-c518t-18b04a0070686045ce68e2167918c42ed6fc8e7a9beb4f8417ad397dda2476a3</originalsourceid><addsrcrecordid>eNqFkcFu1TAQRS0Eoo-2H8AGWWLDxtSTOHbCrqooVHpSF3QfOfbkvVSJHWyHqj_C9-KQghASYmNbumfujOcS8hr4e-BcXUTOq1oyDoKVpRQMnpEdiLJgvCmL52THG8GZVNCckFcx3nMOVcPlS3JSiKYqZMl35PuXpJ1levQO6eX-5po-DOlIB5fwEHRCuz6DNj7MPqAeqXbm6MPgDnQesx6zTtMRacpqmtAl6ntq8YAOc_3wDem4TJ0O1A7RrAfqiB-opnPwcUbzE4lpsY_UOyorarIez8iLXo8Rz5_uU3J3_fHu6jPb3366ubrcM1NBnRjUHRc6r4LLWnJRGZQ1FiBVA7URBVrZmxqVbjrsRF8LUNqWjbJWF0JJXZ6Sd5ttHubrgjG1U54Sx1E79EtsQQLIslJC_h-tZIZBFZDRt3-h934JLv9jo3hOockUbJTJi4gB-3YOw6TDYwu8XeNtt3jbHG-7xtuuzm-enJduQvu74leeGSg2IM5rRhj-aP1P1x_MILBp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1566105909</pqid></control><display><type>article</type><title>Stand-alone ALIF with integrated intracorporeal anchoring plates in the treatment of degenerative lumbar disc disease: a prospective study on 65 cases</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Allain, Jérôme ; Delecrin, Joël ; Beaurain, Jacques ; Poignard, Alexandre ; Vila, Thierry ; Flouzat-Lachaniette, Charles-Henri</creator><creatorcontrib>Allain, Jérôme ; Delecrin, Joël ; Beaurain, Jacques ; Poignard, Alexandre ; Vila, Thierry ; Flouzat-Lachaniette, Charles-Henri</creatorcontrib><description>Purpose
ALIF with cages is expected to restore disc height and stabilize the spine promoting fusion, while avoiding damage attributed to rod-pedicle screw fixation. However, it may be related to an increased risk of fusion failure and subsidence. A prospective study was conducted by five investigators across three centers to confirm performance of a PEEK cage for stand-alone ALIF in the treatment of lumbar degenerative disc disease (DDD).
Methods
Sixty-five patients, with back ± leg pain, requiring surgery for DDD, were included. Efficacy and safety were evaluated at 6 weeks, 3, 6, and 12 months post-operatively. Fusion and subsidence were assessed through CT-images at 12-month follow-up. Disc height was measured. Clinical outcomes included back and leg pain (VAS), disability (Oswestry Disability Index), Quality of Life (Short-Form 36), and adverse events.
Results
The fusion and the subsidence rates were 96.3 and 2.0 %, respectively. ALIF surgery restored anterior and posterior disc height compared to baseline. There were no device-related serious adverse events, and no revision surgeries. Clinical outcomes improved significantly through 12-month follow-up.
Conclusion
Safety and efficacy of this stand-alone cage with integrated intracorporeal plates was confirmed through 12 months for treatment of degenerative conditions. The design of the cage and plates may contribute to the decreased subsidence rate observed.</description><identifier>ISSN: 0940-6719</identifier><identifier>EISSN: 1432-0932</identifier><identifier>DOI: 10.1007/s00586-014-3364-1</identifier><identifier>PMID: 24952630</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bone Plates ; Female ; Follow-Up Studies ; Humans ; Intervertebral Disc Degeneration - surgery ; Intervertebral Disc Displacement - surgery ; Low Back Pain - surgery ; Lumbar Vertebrae - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurosurgery ; Original Article ; Pain Measurement ; Prospective Studies ; Prosthesis Design ; Quality of Life ; Recovery of Function ; Spinal Fusion - instrumentation ; Spinal Fusion - methods ; Surgical Orthopedics ; Total Disc Replacement - instrumentation ; Total Disc Replacement - methods ; Treatment Outcome</subject><ispartof>European spine journal, 2014-10, Vol.23 (10), p.2136-2143</ispartof><rights>The Author(s) 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-18b04a0070686045ce68e2167918c42ed6fc8e7a9beb4f8417ad397dda2476a3</citedby><cites>FETCH-LOGICAL-c518t-18b04a0070686045ce68e2167918c42ed6fc8e7a9beb4f8417ad397dda2476a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00586-014-3364-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00586-014-3364-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24952630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allain, Jérôme</creatorcontrib><creatorcontrib>Delecrin, Joël</creatorcontrib><creatorcontrib>Beaurain, Jacques</creatorcontrib><creatorcontrib>Poignard, Alexandre</creatorcontrib><creatorcontrib>Vila, Thierry</creatorcontrib><creatorcontrib>Flouzat-Lachaniette, Charles-Henri</creatorcontrib><title>Stand-alone ALIF with integrated intracorporeal anchoring plates in the treatment of degenerative lumbar disc disease: a prospective study on 65 cases</title><title>European spine journal</title><addtitle>Eur Spine J</addtitle><addtitle>Eur Spine J</addtitle><description>Purpose
ALIF with cages is expected to restore disc height and stabilize the spine promoting fusion, while avoiding damage attributed to rod-pedicle screw fixation. However, it may be related to an increased risk of fusion failure and subsidence. A prospective study was conducted by five investigators across three centers to confirm performance of a PEEK cage for stand-alone ALIF in the treatment of lumbar degenerative disc disease (DDD).
Methods
Sixty-five patients, with back ± leg pain, requiring surgery for DDD, were included. Efficacy and safety were evaluated at 6 weeks, 3, 6, and 12 months post-operatively. Fusion and subsidence were assessed through CT-images at 12-month follow-up. Disc height was measured. Clinical outcomes included back and leg pain (VAS), disability (Oswestry Disability Index), Quality of Life (Short-Form 36), and adverse events.
Results
The fusion and the subsidence rates were 96.3 and 2.0 %, respectively. ALIF surgery restored anterior and posterior disc height compared to baseline. There were no device-related serious adverse events, and no revision surgeries. Clinical outcomes improved significantly through 12-month follow-up.
Conclusion
Safety and efficacy of this stand-alone cage with integrated intracorporeal plates was confirmed through 12 months for treatment of degenerative conditions. The design of the cage and plates may contribute to the decreased subsidence rate observed.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Plates</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Intervertebral Disc Degeneration - surgery</subject><subject>Intervertebral Disc Displacement - surgery</subject><subject>Low Back Pain - surgery</subject><subject>Lumbar Vertebrae - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Pain Measurement</subject><subject>Prospective Studies</subject><subject>Prosthesis Design</subject><subject>Quality of Life</subject><subject>Recovery of Function</subject><subject>Spinal Fusion - instrumentation</subject><subject>Spinal Fusion - methods</subject><subject>Surgical Orthopedics</subject><subject>Total Disc Replacement - instrumentation</subject><subject>Total Disc Replacement - methods</subject><subject>Treatment Outcome</subject><issn>0940-6719</issn><issn>1432-0932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkcFu1TAQRS0Eoo-2H8AGWWLDxtSTOHbCrqooVHpSF3QfOfbkvVSJHWyHqj_C9-KQghASYmNbumfujOcS8hr4e-BcXUTOq1oyDoKVpRQMnpEdiLJgvCmL52THG8GZVNCckFcx3nMOVcPlS3JSiKYqZMl35PuXpJ1levQO6eX-5po-DOlIB5fwEHRCuz6DNj7MPqAeqXbm6MPgDnQesx6zTtMRacpqmtAl6ntq8YAOc_3wDem4TJ0O1A7RrAfqiB-opnPwcUbzE4lpsY_UOyorarIez8iLXo8Rz5_uU3J3_fHu6jPb3366ubrcM1NBnRjUHRc6r4LLWnJRGZQ1FiBVA7URBVrZmxqVbjrsRF8LUNqWjbJWF0JJXZ6Sd5ttHubrgjG1U54Sx1E79EtsQQLIslJC_h-tZIZBFZDRt3-h934JLv9jo3hOockUbJTJi4gB-3YOw6TDYwu8XeNtt3jbHG-7xtuuzm-enJduQvu74leeGSg2IM5rRhj-aP1P1x_MILBp</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Allain, Jérôme</creator><creator>Delecrin, Joël</creator><creator>Beaurain, Jacques</creator><creator>Poignard, Alexandre</creator><creator>Vila, Thierry</creator><creator>Flouzat-Lachaniette, Charles-Henri</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>Stand-alone ALIF with integrated intracorporeal anchoring plates in the treatment of degenerative lumbar disc disease: a prospective study on 65 cases</title><author>Allain, Jérôme ; Delecrin, Joël ; Beaurain, Jacques ; Poignard, Alexandre ; Vila, Thierry ; Flouzat-Lachaniette, Charles-Henri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-18b04a0070686045ce68e2167918c42ed6fc8e7a9beb4f8417ad397dda2476a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Plates</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Intervertebral Disc Degeneration - surgery</topic><topic>Intervertebral Disc Displacement - surgery</topic><topic>Low Back Pain - surgery</topic><topic>Lumbar Vertebrae - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Pain Measurement</topic><topic>Prospective Studies</topic><topic>Prosthesis Design</topic><topic>Quality of Life</topic><topic>Recovery of Function</topic><topic>Spinal Fusion - instrumentation</topic><topic>Spinal Fusion - methods</topic><topic>Surgical Orthopedics</topic><topic>Total Disc Replacement - instrumentation</topic><topic>Total Disc Replacement - methods</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allain, Jérôme</creatorcontrib><creatorcontrib>Delecrin, Joël</creatorcontrib><creatorcontrib>Beaurain, Jacques</creatorcontrib><creatorcontrib>Poignard, Alexandre</creatorcontrib><creatorcontrib>Vila, Thierry</creatorcontrib><creatorcontrib>Flouzat-Lachaniette, Charles-Henri</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European spine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allain, Jérôme</au><au>Delecrin, Joël</au><au>Beaurain, Jacques</au><au>Poignard, Alexandre</au><au>Vila, Thierry</au><au>Flouzat-Lachaniette, Charles-Henri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stand-alone ALIF with integrated intracorporeal anchoring plates in the treatment of degenerative lumbar disc disease: a prospective study on 65 cases</atitle><jtitle>European spine journal</jtitle><stitle>Eur Spine J</stitle><addtitle>Eur Spine J</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>23</volume><issue>10</issue><spage>2136</spage><epage>2143</epage><pages>2136-2143</pages><issn>0940-6719</issn><eissn>1432-0932</eissn><abstract>Purpose
ALIF with cages is expected to restore disc height and stabilize the spine promoting fusion, while avoiding damage attributed to rod-pedicle screw fixation. However, it may be related to an increased risk of fusion failure and subsidence. A prospective study was conducted by five investigators across three centers to confirm performance of a PEEK cage for stand-alone ALIF in the treatment of lumbar degenerative disc disease (DDD).
Methods
Sixty-five patients, with back ± leg pain, requiring surgery for DDD, were included. Efficacy and safety were evaluated at 6 weeks, 3, 6, and 12 months post-operatively. Fusion and subsidence were assessed through CT-images at 12-month follow-up. Disc height was measured. Clinical outcomes included back and leg pain (VAS), disability (Oswestry Disability Index), Quality of Life (Short-Form 36), and adverse events.
Results
The fusion and the subsidence rates were 96.3 and 2.0 %, respectively. ALIF surgery restored anterior and posterior disc height compared to baseline. There were no device-related serious adverse events, and no revision surgeries. Clinical outcomes improved significantly through 12-month follow-up.
Conclusion
Safety and efficacy of this stand-alone cage with integrated intracorporeal plates was confirmed through 12 months for treatment of degenerative conditions. The design of the cage and plates may contribute to the decreased subsidence rate observed.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24952630</pmid><doi>10.1007/s00586-014-3364-1</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Aged Aged, 80 and over Bone Plates Female Follow-Up Studies Humans Intervertebral Disc Degeneration - surgery Intervertebral Disc Displacement - surgery Low Back Pain - surgery Lumbar Vertebrae - surgery Male Medicine Medicine & Public Health Middle Aged Neurosurgery Original Article Pain Measurement Prospective Studies Prosthesis Design Quality of Life Recovery of Function Spinal Fusion - instrumentation Spinal Fusion - methods Surgical Orthopedics Total Disc Replacement - instrumentation Total Disc Replacement - methods Treatment Outcome |
| title | Stand-alone ALIF with integrated intracorporeal anchoring plates in the treatment of degenerative lumbar disc disease: a prospective study on 65 cases |
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