Trace minerals status and antioxidative enzyme activity in dogs with generalized demodecosis
The present study was aimed to determine the levels of trace elements zinc, copper, iron, erythrocyte oxidant/anti-oxidant balance, vitamin C and β-carotene in dogs with generalized demodecosis. A total of 24 dogs with clinically established diagnosis of generalized demodecosis and 6 dogs as control...
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| Veröffentlicht in: | Veterinary parasitology 2013-11, Vol.198 (1-2), p.180-186 |
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| creator | Beigh, S.A. Soodan, J.S. Singh, R. Khan, A.M. |
| description | The present study was aimed to determine the levels of trace elements zinc, copper, iron, erythrocyte oxidant/anti-oxidant balance, vitamin C and β-carotene in dogs with generalized demodecosis. A total of 24 dogs with clinically established diagnosis of generalized demodecosis and 6 dogs as control were included in the study. In comparison to healthy control, zinc and copper levels were significantly (P |
| doi_str_mv | 10.1016/j.vetpar.2013.08.001 |
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A total of 24 dogs with clinically established diagnosis of generalized demodecosis and 6 dogs as control were included in the study. In comparison to healthy control, zinc and copper levels were significantly (P<0.01) lower in dogs with generalized demodecosis, whereas iron levels were significantly (P<0.01) higher. Malondialdehyde (MDA) levels were significantly (P<0.01) higher in diseased dogs whereas activity of superoxide dismutase (SOD) and catalase were significantly (P<0.01) lower. β-carotene and vitamin C levels were significantly (P<0.05) lower in diseased dogs when compared to healthy control. SOD activity was positively correlated with zinc (rs=0.65, rs=0.71 and P<0.05) and copper (rs=0.51, rs=0.63 and P<0.05) in both healthy and diseased dogs. MDA levels were negatively correlated with iron (rs=−0.49, rs=−0.78 and P<0.05), β-carotene (rs=−0.26, P>0.05; rs=−0.54, P<0.05, respectively) in both healthy and diseased dogs and with SOD activity in diseased dogs only (rs=−0.68, P<0.05). From the present study, it was concluded that generalized demodecosis in dogs is associated with significant alteration in trace elements and oxidant/anti-oxidant imbalance and this imbalance might be secondary to changes caused by demodectic mange.]]></description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/j.vetpar.2013.08.001</identifier><identifier>PMID: 23993634</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antioxidants ; Antioxidants - metabolism ; ascorbic acid ; beta-carotene ; catalase ; Copper ; correlation ; demodicosis ; Dog Diseases - blood ; Dog Diseases - enzymology ; Dogs ; enzyme activity ; Female ; Iron ; Male ; mange ; Mite Infestations - metabolism ; Mite Infestations - parasitology ; Mite Infestations - veterinary ; Oxidants and vitamin C ; superoxide dismutase ; Trace Elements - blood ; zinc ; β-carotene</subject><ispartof>Veterinary parasitology, 2013-11, Vol.198 (1-2), p.180-186</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-21ff575c4bba486789ed35a981db37e7d16f8c5e3fd1392b8914532c048a7bb53</citedby><cites>FETCH-LOGICAL-c419t-21ff575c4bba486789ed35a981db37e7d16f8c5e3fd1392b8914532c048a7bb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304401713004494$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23993634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beigh, S.A.</creatorcontrib><creatorcontrib>Soodan, J.S.</creatorcontrib><creatorcontrib>Singh, R.</creatorcontrib><creatorcontrib>Khan, A.M.</creatorcontrib><title>Trace minerals status and antioxidative enzyme activity in dogs with generalized demodecosis</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description><![CDATA[The present study was aimed to determine the levels of trace elements zinc, copper, iron, erythrocyte oxidant/anti-oxidant balance, vitamin C and β-carotene in dogs with generalized demodecosis. A total of 24 dogs with clinically established diagnosis of generalized demodecosis and 6 dogs as control were included in the study. In comparison to healthy control, zinc and copper levels were significantly (P<0.01) lower in dogs with generalized demodecosis, whereas iron levels were significantly (P<0.01) higher. Malondialdehyde (MDA) levels were significantly (P<0.01) higher in diseased dogs whereas activity of superoxide dismutase (SOD) and catalase were significantly (P<0.01) lower. β-carotene and vitamin C levels were significantly (P<0.05) lower in diseased dogs when compared to healthy control. SOD activity was positively correlated with zinc (rs=0.65, rs=0.71 and P<0.05) and copper (rs=0.51, rs=0.63 and P<0.05) in both healthy and diseased dogs. MDA levels were negatively correlated with iron (rs=−0.49, rs=−0.78 and P<0.05), β-carotene (rs=−0.26, P>0.05; rs=−0.54, P<0.05, respectively) in both healthy and diseased dogs and with SOD activity in diseased dogs only (rs=−0.68, P<0.05). From the present study, it was concluded that generalized demodecosis in dogs is associated with significant alteration in trace elements and oxidant/anti-oxidant imbalance and this imbalance might be secondary to changes caused by demodectic mange.]]></description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>ascorbic acid</subject><subject>beta-carotene</subject><subject>catalase</subject><subject>Copper</subject><subject>correlation</subject><subject>demodicosis</subject><subject>Dog Diseases - blood</subject><subject>Dog Diseases - enzymology</subject><subject>Dogs</subject><subject>enzyme activity</subject><subject>Female</subject><subject>Iron</subject><subject>Male</subject><subject>mange</subject><subject>Mite Infestations - metabolism</subject><subject>Mite Infestations - parasitology</subject><subject>Mite Infestations - veterinary</subject><subject>Oxidants and vitamin C</subject><subject>superoxide dismutase</subject><subject>Trace Elements - blood</subject><subject>zinc</subject><subject>β-carotene</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFCEYhonR2O3qPzDK0cuMfAPMwMXENGpNmniwvZkQBr5Z2ezMrMBu3f56aad6VBJCSJ73hXwPIa-A1cCgfbetj5j3NtYNA14zVTMGT8gKVMerRkr2lKwYZ6ISDLozcp7SljEmWNs9J2cN15q3XKzI9-toHdIxTBjtLtGUbT4kaidfdg7zr-BtDkekON2dRqTWlVvIJxom6udNorch_6AbfIiHO_TU4zh7dHMK6QV5NpRSfPl4rsnNp4_XF5fV1dfPXy4-XFVOgM5VA8MgO-lE31uh2k5p9FxarcD3vMPOQzsoJ5EPHrhueqVBSN44JpTt-l7yNXm79O7j_POAKZsxJIe7nZ1wPiQDLUDLJXD2f1QIzrXkZa2JWFAX55QiDmYfw2jjyQAz9wrM1iwKzL0Cw5QpCkrs9eMLh35E_zf0Z-YFeLMAg52N3cSQzM230iCKHwD9UPF-IbAM7RgwmuQCTg59iOiy8XP49x9-A2iZo0w</recordid><startdate>20131115</startdate><enddate>20131115</enddate><creator>Beigh, S.A.</creator><creator>Soodan, J.S.</creator><creator>Singh, R.</creator><creator>Khan, A.M.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SS</scope></search><sort><creationdate>20131115</creationdate><title>Trace minerals status and antioxidative enzyme activity in dogs with generalized demodecosis</title><author>Beigh, S.A. ; Soodan, J.S. ; Singh, R. ; Khan, A.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-21ff575c4bba486789ed35a981db37e7d16f8c5e3fd1392b8914532c048a7bb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>ascorbic acid</topic><topic>beta-carotene</topic><topic>catalase</topic><topic>Copper</topic><topic>correlation</topic><topic>demodicosis</topic><topic>Dog Diseases - blood</topic><topic>Dog Diseases - enzymology</topic><topic>Dogs</topic><topic>enzyme activity</topic><topic>Female</topic><topic>Iron</topic><topic>Male</topic><topic>mange</topic><topic>Mite Infestations - metabolism</topic><topic>Mite Infestations - parasitology</topic><topic>Mite Infestations - veterinary</topic><topic>Oxidants and vitamin C</topic><topic>superoxide dismutase</topic><topic>Trace Elements - blood</topic><topic>zinc</topic><topic>β-carotene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beigh, S.A.</creatorcontrib><creatorcontrib>Soodan, J.S.</creatorcontrib><creatorcontrib>Singh, R.</creatorcontrib><creatorcontrib>Khan, A.M.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Entomology Abstracts (Full archive)</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beigh, S.A.</au><au>Soodan, J.S.</au><au>Singh, R.</au><au>Khan, A.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trace minerals status and antioxidative enzyme activity in dogs with generalized demodecosis</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>2013-11-15</date><risdate>2013</risdate><volume>198</volume><issue>1-2</issue><spage>180</spage><epage>186</epage><pages>180-186</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract><![CDATA[The present study was aimed to determine the levels of trace elements zinc, copper, iron, erythrocyte oxidant/anti-oxidant balance, vitamin C and β-carotene in dogs with generalized demodecosis. A total of 24 dogs with clinically established diagnosis of generalized demodecosis and 6 dogs as control were included in the study. In comparison to healthy control, zinc and copper levels were significantly (P<0.01) lower in dogs with generalized demodecosis, whereas iron levels were significantly (P<0.01) higher. Malondialdehyde (MDA) levels were significantly (P<0.01) higher in diseased dogs whereas activity of superoxide dismutase (SOD) and catalase were significantly (P<0.01) lower. β-carotene and vitamin C levels were significantly (P<0.05) lower in diseased dogs when compared to healthy control. SOD activity was positively correlated with zinc (rs=0.65, rs=0.71 and P<0.05) and copper (rs=0.51, rs=0.63 and P<0.05) in both healthy and diseased dogs. MDA levels were negatively correlated with iron (rs=−0.49, rs=−0.78 and P<0.05), β-carotene (rs=−0.26, P>0.05; rs=−0.54, P<0.05, respectively) in both healthy and diseased dogs and with SOD activity in diseased dogs only (rs=−0.68, P<0.05). From the present study, it was concluded that generalized demodecosis in dogs is associated with significant alteration in trace elements and oxidant/anti-oxidant imbalance and this imbalance might be secondary to changes caused by demodectic mange.]]></abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23993634</pmid><doi>10.1016/j.vetpar.2013.08.001</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antioxidants Antioxidants - metabolism ascorbic acid beta-carotene catalase Copper correlation demodicosis Dog Diseases - blood Dog Diseases - enzymology Dogs enzyme activity Female Iron Male mange Mite Infestations - metabolism Mite Infestations - parasitology Mite Infestations - veterinary Oxidants and vitamin C superoxide dismutase Trace Elements - blood zinc β-carotene |
| title | Trace minerals status and antioxidative enzyme activity in dogs with generalized demodecosis |
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