Effect of sildenafil on skeletal and cardiac muscle in Becker muscular dystrophy

Objective Patients with Becker muscular dystrophy (BMD) and Duchenne muscular dystrophy lack neuronal nitric oxide synthase (nNOS). nNOS mediates physiological sympatholysis, thus ensuring adequate blood supply to working muscle. In mice lacking dystrophin, restoration of nNOS effects by a phosphodi...

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Veröffentlicht in:	Annals of neurology 2014-10, Vol.76 (4), p.550-557
Hauptverfasser:	Witting, Nanna, Kruuse, Christina, Nyhuus, Bo, Prahm, Kira P., Citirak, Gulsenay, Lundgaard, Stine J., von Huth, Sebastian, Vejlstrup, Niels, Lindberg, Ulrich, Krag, Thomas O., Vissing, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism Double-Blind Method Female Follow-Up Studies Hand Strength - physiology Humans Locomotion - drug effects Magnetic Resonance Imaging Male Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscular dystrophy Muscular Dystrophy, Duchenne - drug therapy Muscular Dystrophy, Duchenne - pathology Myocardium - pathology Nitric Oxide Synthase Type I - metabolism NMR Nuclear magnetic resonance Piperazines - therapeutic use Purines - therapeutic use Regional Blood Flow - drug effects Rodents Sildenafil Citrate Sulfones - therapeutic use Vasodilator Agents - therapeutic use Young Adult
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