Polyols accumulated in ribose-5-phosphate isomerase deficiency increase mitochondrial superoxide production and improve antioxidant defenses in rats’ prefrontal cortex

•Ribitol contributes to mitochondrial superoxide generation.•Ribitol enhances the antioxidant system, increasing antioxidant enzymes activities.•Polyols did not modify lipids and proteins oxidation in prefrontal cortex. The ribose-5-phosphate isomerase deficiency is an inherited condition, which res...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of developmental neuroscience 2014-10, Vol.37 (1), p.21-25
Hauptverfasser:	Stone, V., Kudo, K.Y., August, P.M., Marcelino, T.B., Matté, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldose-Ketose Isomerases - deficiency Analysis of Variance Animals Antioxidants - pharmacology Catalase - metabolism Female Flow Cytometry Glutathione - metabolism Glutathione Peroxidase - metabolism In vitro In Vitro Techniques Lipid Peroxidation - drug effects Mitochondria - drug effects Mitochondria - metabolism Organ Culture Techniques Oxidative stress Polyol Prefrontal Cortex - drug effects Rat Rats Rats, Wistar Ribitol Ribitol - pharmacology Ribose-5-phosphate-isomerase Sugar Alcohols - pharmacology Superoxide Dismutase - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!