Effects of oxymatrine on the apoptosis and proliferation of gallbladder cancer cells

Gallbladder carcinoma is the most common malignancy of the biliary tract and is associated with a very poor outcome. The aim of the present study was to investigate the effects of oxymatrine (OM) on gallbladder cancer cells and the possible mechanism of its effects. The effects of OM on the prolifer...

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Veröffentlicht in:	Anti-cancer drugs 2014-10, Vol.25 (9), p.1007-1015
Hauptverfasser:	Wu, Xiang-Song, Yang, Tian, Gu, Jun, Li, Mao-Lan, Wu, Wen-Guang, Weng, Hao, Ding, Qian, Mu, Jia-Sheng, Bao, Run-Fa, Shu, Yi-Jun, Cao, Yang, Wang, Xu-an, Ding, Qi-Chen, Dong, Ping, Xie, Shun-Feng, Liu, Ying-Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Alkaloids - therapeutic use Animals Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Gallbladder Neoplasms - drug therapy Gallbladder Neoplasms - pathology Humans Membrane Potential, Mitochondrial - drug effects Mice, Nude NF-kappa B - metabolism Phytotherapy Proto-Oncogene Proteins c-bcl-2 - metabolism Quinolizines - pharmacology Quinolizines - therapeutic use Xenograft Model Antitumor Assays
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