A high-throughput LC-MS/MS screen for GHRP in equine and human urine, featuring peptide derivatization for improved chromatography

The growth hormone releasing peptides (GHRPs) hexarelin, ipamorelin, alexamorelin, GHRP‐1, GHRP‐2, GHRP‐4, GHRP‐5, and GHRP‐6 are all synthetic met‐enkephalin analogues that include unnatural D‐amino acids. They were designed specifically for their ability to stimulate growth hormone release and may...

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Veröffentlicht in:	Drug testing and analysis 2014-10, Vol.6 (10), p.985-995
Hauptverfasser:	Timms, Mark, Hall, Nikki, Levina, Vita, Vine, John, Steel, Rohan
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Animals Chromatography, Liquid - methods derivatization Doping in Sports - prevention & control GHRP Growth Hormone-Releasing Hormone - analogs & derivatives Growth Hormone-Releasing Hormone - analysis Growth Hormone-Releasing Hormone - urine High-Throughput Screening Assays - methods Horses Humans Male mass spectrometry Rats Rats, Sprague-Dawley Sensitivity and Specificity Solid Phase Extraction Substance Abuse Detection - methods Tandem Mass Spectrometry - methods urine
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