Distribution of three SNPs related to low bone mineral density in amerindian groups and mestizos from Mexico
Objectives: Some Single nucleotide polymorphisms (SNPs) of several candidate genes have been associated with low bone mineral density (BMD) and fracture risk. As the genetic variability of such SNPs in Hispanic and Native American populations is scarce, we analyzed the three SNPs that have been rela...
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creator | Nuño-Arana, Ismael Sahagún-Núñez, Valeria Del Rocío Muñoz-Valle, José Francisco Sandoval, Lucila Pinto-Escalante, Doris Páez-Riberos, Luis Antonio Lazalde, Brissia Maldonado-González, Montserrat Rangel-Villalobos, Héctor |
description | Objectives:
Some Single nucleotide polymorphisms (SNPs) of several candidate genes have been associated with low bone mineral density (BMD) and fracture risk. As the genetic variability of such SNPs in Hispanic and Native American populations is scarce, we analyzed the three SNPs that have been related with bone mass disorders (Sp1, A163G, and BsmI) located in the genes of Type I Collagen (COL1A1), Osteoprotegerin (OPG), and Vitamin D receptor (VDR) in Mexican Mestizos (people resulting from post‐Columbian admixture) and five Amerindian populations.
Methods:
We genotyped these three SNPs by Polymerase chain reaction (PCR) and Restriction fragment length polymorphisms (RFLPs) in 523 individuals from five Mexican Amerindian groups (Nahua, Maya, Purépecha, Tarahumara, and Huichol) and 227 western Mestizos (Jalisco state).
Results:
The modal allele was the same in all the six populations for Sp1‐COL1A1 (S > 77%), A163G‐OPG (A > 80%), and BsmI‐VDR (b > 62%). Genotype distribution was in Hardy‐Weinberg equilibrium in all SNPs/populations, excepting Sp1‐COL1A1 in the Purépecha group and BsmI‐VDR in Mestizo. In terms of the presumably Sp1‐COL1A1 risk allele to low BMD (allele “s”), the Purépecha group showed the highest allele (23%) and homozygous (14.5%) frequencies. If the role of this allele as a genetic predisposing factor to low BMD were confirmed, this would mean increased susceptibility of Purépechas with regard to Europeans (14.5 vs. 6.8%).
Conclusions:
This finding presumably could influence the genetic susceptibility to low BMD in Purépechas. For the SNPs, BsmI‐VDR and A163G‐OPG, relative homogeneity was observed among the Mexican populations analyzed here. Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc. |
doi_str_mv | 10.1002/ajhb.22262 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1611618618</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1020050710</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4282-74074c1f8765302a031c6e60857a1d585dd58307e6c6f86f295b77556eb1b3673</originalsourceid><addsrcrecordid>eNqFkUFv1DAQhS0EomXhwg9AlrggpLRjO7azx9KWlmpbkChabpaTTKiXxN7aidrl1-OybQ8cQBrN-PDN0xs_Ql4z2GMAfN-uruo9zrniT8gukxwKJQCe5jeUvAApxA55kdIKAOYKqudkh_NSlErCLumPXBqjq6fRBU9DR8eriEi_XnxJNGJvR2zpGGgfbmgdPNLBeYy2py365MYNdZ7aAaPzrbOe_ohhWidqfUsHTKP7FRLtYhjoOd66JrwkzzrbJ3x1P2fk28fjy8PTYvH55NPhwaJoSl7xQpegy4Z1lVZSALcgWKMwO5faslZWss1NgEbVqK5SHZ_LWmspFdasFkqLGXm31V3HcD1lI2ZwqcG-tx7DlAxTLFeV6_8ocAAJmkFG3_6FrsIUfT7EMFmWldI8-52R91uqiSGliJ1ZRzfYuMlS5i4ucxeX-RNXht_cS071gO0j-pBPBtgWuHE9bv4hZQ7OTj88iBbbnZws3j7u2PjT5L_R0iwvTszZcvn9aKHm5lL8BgearKs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1544867265</pqid></control><display><type>article</type><title>Distribution of three SNPs related to low bone mineral density in amerindian groups and mestizos from Mexico</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Nuño-Arana, Ismael ; Sahagún-Núñez, Valeria Del Rocío ; Muñoz-Valle, José Francisco ; Sandoval, Lucila ; Pinto-Escalante, Doris ; Páez-Riberos, Luis Antonio ; Lazalde, Brissia ; Maldonado-González, Montserrat ; Rangel-Villalobos, Héctor</creator><creatorcontrib>Nuño-Arana, Ismael ; Sahagún-Núñez, Valeria Del Rocío ; Muñoz-Valle, José Francisco ; Sandoval, Lucila ; Pinto-Escalante, Doris ; Páez-Riberos, Luis Antonio ; Lazalde, Brissia ; Maldonado-González, Montserrat ; Rangel-Villalobos, Héctor</creatorcontrib><description>Objectives:
Some Single nucleotide polymorphisms (SNPs) of several candidate genes have been associated with low bone mineral density (BMD) and fracture risk. As the genetic variability of such SNPs in Hispanic and Native American populations is scarce, we analyzed the three SNPs that have been related with bone mass disorders (Sp1, A163G, and BsmI) located in the genes of Type I Collagen (COL1A1), Osteoprotegerin (OPG), and Vitamin D receptor (VDR) in Mexican Mestizos (people resulting from post‐Columbian admixture) and five Amerindian populations.
Methods:
We genotyped these three SNPs by Polymerase chain reaction (PCR) and Restriction fragment length polymorphisms (RFLPs) in 523 individuals from five Mexican Amerindian groups (Nahua, Maya, Purépecha, Tarahumara, and Huichol) and 227 western Mestizos (Jalisco state).
Results:
The modal allele was the same in all the six populations for Sp1‐COL1A1 (S > 77%), A163G‐OPG (A > 80%), and BsmI‐VDR (b > 62%). Genotype distribution was in Hardy‐Weinberg equilibrium in all SNPs/populations, excepting Sp1‐COL1A1 in the Purépecha group and BsmI‐VDR in Mestizo. In terms of the presumably Sp1‐COL1A1 risk allele to low BMD (allele “s”), the Purépecha group showed the highest allele (23%) and homozygous (14.5%) frequencies. If the role of this allele as a genetic predisposing factor to low BMD were confirmed, this would mean increased susceptibility of Purépechas with regard to Europeans (14.5 vs. 6.8%).
Conclusions:
This finding presumably could influence the genetic susceptibility to low BMD in Purépechas. For the SNPs, BsmI‐VDR and A163G‐OPG, relative homogeneity was observed among the Mexican populations analyzed here. Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 1042-0533</identifier><identifier>EISSN: 1520-6300</identifier><identifier>DOI: 10.1002/ajhb.22262</identifier><identifier>PMID: 22434650</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Bone Density ; Collagen Type I - genetics ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Indians, North American ; Mexico ; Osteoporosis - etiology ; Osteoporosis - genetics ; Osteoprotegerin - genetics ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Receptors, Calcitriol - genetics</subject><ispartof>American journal of human biology, 2012-07, Vol.24 (4), p.569-572</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4282-74074c1f8765302a031c6e60857a1d585dd58307e6c6f86f295b77556eb1b3673</citedby><cites>FETCH-LOGICAL-c4282-74074c1f8765302a031c6e60857a1d585dd58307e6c6f86f295b77556eb1b3673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajhb.22262$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajhb.22262$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22434650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nuño-Arana, Ismael</creatorcontrib><creatorcontrib>Sahagún-Núñez, Valeria Del Rocío</creatorcontrib><creatorcontrib>Muñoz-Valle, José Francisco</creatorcontrib><creatorcontrib>Sandoval, Lucila</creatorcontrib><creatorcontrib>Pinto-Escalante, Doris</creatorcontrib><creatorcontrib>Páez-Riberos, Luis Antonio</creatorcontrib><creatorcontrib>Lazalde, Brissia</creatorcontrib><creatorcontrib>Maldonado-González, Montserrat</creatorcontrib><creatorcontrib>Rangel-Villalobos, Héctor</creatorcontrib><title>Distribution of three SNPs related to low bone mineral density in amerindian groups and mestizos from Mexico</title><title>American journal of human biology</title><addtitle>Am. J. Hum. Biol</addtitle><description>Objectives:
Some Single nucleotide polymorphisms (SNPs) of several candidate genes have been associated with low bone mineral density (BMD) and fracture risk. As the genetic variability of such SNPs in Hispanic and Native American populations is scarce, we analyzed the three SNPs that have been related with bone mass disorders (Sp1, A163G, and BsmI) located in the genes of Type I Collagen (COL1A1), Osteoprotegerin (OPG), and Vitamin D receptor (VDR) in Mexican Mestizos (people resulting from post‐Columbian admixture) and five Amerindian populations.
Methods:
We genotyped these three SNPs by Polymerase chain reaction (PCR) and Restriction fragment length polymorphisms (RFLPs) in 523 individuals from five Mexican Amerindian groups (Nahua, Maya, Purépecha, Tarahumara, and Huichol) and 227 western Mestizos (Jalisco state).
Results:
The modal allele was the same in all the six populations for Sp1‐COL1A1 (S > 77%), A163G‐OPG (A > 80%), and BsmI‐VDR (b > 62%). Genotype distribution was in Hardy‐Weinberg equilibrium in all SNPs/populations, excepting Sp1‐COL1A1 in the Purépecha group and BsmI‐VDR in Mestizo. In terms of the presumably Sp1‐COL1A1 risk allele to low BMD (allele “s”), the Purépecha group showed the highest allele (23%) and homozygous (14.5%) frequencies. If the role of this allele as a genetic predisposing factor to low BMD were confirmed, this would mean increased susceptibility of Purépechas with regard to Europeans (14.5 vs. 6.8%).
Conclusions:
This finding presumably could influence the genetic susceptibility to low BMD in Purépechas. For the SNPs, BsmI‐VDR and A163G‐OPG, relative homogeneity was observed among the Mexican populations analyzed here. Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc.</description><subject>Bone Density</subject><subject>Collagen Type I - genetics</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Indians, North American</subject><subject>Mexico</subject><subject>Osteoporosis - etiology</subject><subject>Osteoporosis - genetics</subject><subject>Osteoprotegerin - genetics</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, Calcitriol - genetics</subject><issn>1042-0533</issn><issn>1520-6300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EomXhwg9AlrggpLRjO7azx9KWlmpbkChabpaTTKiXxN7aidrl1-OybQ8cQBrN-PDN0xs_Ql4z2GMAfN-uruo9zrniT8gukxwKJQCe5jeUvAApxA55kdIKAOYKqudkh_NSlErCLumPXBqjq6fRBU9DR8eriEi_XnxJNGJvR2zpGGgfbmgdPNLBeYy2py365MYNdZ7aAaPzrbOe_ohhWidqfUsHTKP7FRLtYhjoOd66JrwkzzrbJ3x1P2fk28fjy8PTYvH55NPhwaJoSl7xQpegy4Z1lVZSALcgWKMwO5faslZWss1NgEbVqK5SHZ_LWmspFdasFkqLGXm31V3HcD1lI2ZwqcG-tx7DlAxTLFeV6_8ocAAJmkFG3_6FrsIUfT7EMFmWldI8-52R91uqiSGliJ1ZRzfYuMlS5i4ucxeX-RNXht_cS071gO0j-pBPBtgWuHE9bv4hZQ7OTj88iBbbnZws3j7u2PjT5L_R0iwvTszZcvn9aKHm5lL8BgearKs</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Nuño-Arana, Ismael</creator><creator>Sahagún-Núñez, Valeria Del Rocío</creator><creator>Muñoz-Valle, José Francisco</creator><creator>Sandoval, Lucila</creator><creator>Pinto-Escalante, Doris</creator><creator>Páez-Riberos, Luis Antonio</creator><creator>Lazalde, Brissia</creator><creator>Maldonado-González, Montserrat</creator><creator>Rangel-Villalobos, Héctor</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7SN</scope><scope>7ST</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>201207</creationdate><title>Distribution of three SNPs related to low bone mineral density in amerindian groups and mestizos from Mexico</title><author>Nuño-Arana, Ismael ; Sahagún-Núñez, Valeria Del Rocío ; Muñoz-Valle, José Francisco ; Sandoval, Lucila ; Pinto-Escalante, Doris ; Páez-Riberos, Luis Antonio ; Lazalde, Brissia ; Maldonado-González, Montserrat ; Rangel-Villalobos, Héctor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4282-74074c1f8765302a031c6e60857a1d585dd58307e6c6f86f295b77556eb1b3673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Bone Density</topic><topic>Collagen Type I - genetics</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Indians, North American</topic><topic>Mexico</topic><topic>Osteoporosis - etiology</topic><topic>Osteoporosis - genetics</topic><topic>Osteoprotegerin - genetics</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, Calcitriol - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nuño-Arana, Ismael</creatorcontrib><creatorcontrib>Sahagún-Núñez, Valeria Del Rocío</creatorcontrib><creatorcontrib>Muñoz-Valle, José Francisco</creatorcontrib><creatorcontrib>Sandoval, Lucila</creatorcontrib><creatorcontrib>Pinto-Escalante, Doris</creatorcontrib><creatorcontrib>Páez-Riberos, Luis Antonio</creatorcontrib><creatorcontrib>Lazalde, Brissia</creatorcontrib><creatorcontrib>Maldonado-González, Montserrat</creatorcontrib><creatorcontrib>Rangel-Villalobos, Héctor</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ecology Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of human biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nuño-Arana, Ismael</au><au>Sahagún-Núñez, Valeria Del Rocío</au><au>Muñoz-Valle, José Francisco</au><au>Sandoval, Lucila</au><au>Pinto-Escalante, Doris</au><au>Páez-Riberos, Luis Antonio</au><au>Lazalde, Brissia</au><au>Maldonado-González, Montserrat</au><au>Rangel-Villalobos, Héctor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of three SNPs related to low bone mineral density in amerindian groups and mestizos from Mexico</atitle><jtitle>American journal of human biology</jtitle><addtitle>Am. J. Hum. Biol</addtitle><date>2012-07</date><risdate>2012</risdate><volume>24</volume><issue>4</issue><spage>569</spage><epage>572</epage><pages>569-572</pages><issn>1042-0533</issn><eissn>1520-6300</eissn><abstract>Objectives:
Some Single nucleotide polymorphisms (SNPs) of several candidate genes have been associated with low bone mineral density (BMD) and fracture risk. As the genetic variability of such SNPs in Hispanic and Native American populations is scarce, we analyzed the three SNPs that have been related with bone mass disorders (Sp1, A163G, and BsmI) located in the genes of Type I Collagen (COL1A1), Osteoprotegerin (OPG), and Vitamin D receptor (VDR) in Mexican Mestizos (people resulting from post‐Columbian admixture) and five Amerindian populations.
Methods:
We genotyped these three SNPs by Polymerase chain reaction (PCR) and Restriction fragment length polymorphisms (RFLPs) in 523 individuals from five Mexican Amerindian groups (Nahua, Maya, Purépecha, Tarahumara, and Huichol) and 227 western Mestizos (Jalisco state).
Results:
The modal allele was the same in all the six populations for Sp1‐COL1A1 (S > 77%), A163G‐OPG (A > 80%), and BsmI‐VDR (b > 62%). Genotype distribution was in Hardy‐Weinberg equilibrium in all SNPs/populations, excepting Sp1‐COL1A1 in the Purépecha group and BsmI‐VDR in Mestizo. In terms of the presumably Sp1‐COL1A1 risk allele to low BMD (allele “s”), the Purépecha group showed the highest allele (23%) and homozygous (14.5%) frequencies. If the role of this allele as a genetic predisposing factor to low BMD were confirmed, this would mean increased susceptibility of Purépechas with regard to Europeans (14.5 vs. 6.8%).
Conclusions:
This finding presumably could influence the genetic susceptibility to low BMD in Purépechas. For the SNPs, BsmI‐VDR and A163G‐OPG, relative homogeneity was observed among the Mexican populations analyzed here. Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22434650</pmid><doi>10.1002/ajhb.22262</doi><tpages>4</tpages></addata></record> |
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subjects | Bone Density Collagen Type I - genetics Gene Frequency Genetic Predisposition to Disease Genotype Humans Indians, North American Mexico Osteoporosis - etiology Osteoporosis - genetics Osteoprotegerin - genetics Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Receptors, Calcitriol - genetics |
title | Distribution of three SNPs related to low bone mineral density in amerindian groups and mestizos from Mexico |
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