Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102 : structural studies on specific CYP2D6 substrate metabolism

1. A molecular model of CYP2D6 has been constructed from the bacterial form CYP102 via a homology alignment between the CYP2D subfamily and CYP102 protein sequences. 2. A number of typical CYP2D6 substrates are shown to fit the putative active site of the enzyme, as can the specific inhibitor quinid...

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Veröffentlicht in:	Xenobiotica 1997-04, Vol.27 (4), p.319-339
Hauptverfasser:	LEWIS, D. F. V, EDDERSHAW, P. J, GOLDFARB, P. S, TARBIT, M. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Analytical, structural and metabolic biochemistry Bacterial Proteins Biological and medical sciences Cytochrome P-450 CYP2D6 - chemistry Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - metabolism Mixed Function Oxygenases - chemistry Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed NADPH-Ferrihemoprotein Reductase Ondansetron - metabolism Oxidoreductases Polymorphism, Genetic Sequence Homology, Amino Acid Serotonin Antagonists - metabolism
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