Kinetics of ddI in Plasma, Brain, and CSF of Rats after Administration of ddI and an Ester Prodrug of ddI

The clinical course of AIDS dementia complex can be correlated with HIV replication in the CNS, suggesting a need for antiviral drugs that readily cross the blood-brain barrier. The present study was undertaken to characterize the pharmacokinetic parameters of dideoxyinosine (ddI) in plasma, brain,...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 1990-12, Vol.616 (1), p.472-474
Hauptverfasser:	ANDERSON, BRADLEY D., HOESTEREY, BARBARA L., BAKER, DAVID C., GALINSKY, RAYMOND E.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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