The Diabetogenic Effects of Acute Verapamil Poisoning

Verapamil poisoning is known to produce hyperglycemia and metabolic acidosis in humans. The purpose of this study was to elucidate mechanisms of verapamil-induced hyperglycemia in awake dogs. Mongrel canines were chronically instrumented to permit studies in the conscious state. In six healthy dogs,...

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Veröffentlicht in:	Toxicology and applied pharmacology 1997-08, Vol.145 (2), p.357-362
Hauptverfasser:	Kline, Jeffrey A., Raymond, Richard M., Schroeder, J.David, Watts, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Dogs Drug intoxications. Doping Female Glucagon - therapeutic use Glucose - therapeutic use Hyperglycemia - blood Hyperglycemia - chemically induced Hyperglycemia - drug therapy Infusions, Intravenous Insulin - therapeutic use Insulin Antagonists - toxicity Male Medical sciences Pharmacology. Drug treatments Sodium Chloride - therapeutic use Verapamil - toxicity
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