Epiligrin, a new cell adhesion ligand for integrin alpha 3 gamma 1 in epithelial basement membranes

Epiligrin, a new cell adhesion ligand for integrin alpha 3 gamma 1 in epithelial basement membranes

Epiligrin is a new glycoprotein in most epithelial basement membranes and is a ligand for cell adhesion via integrin alpha 3 beta 1. In the extracellular matrix of human foreskin keratinocytes, epiligrin contains three disulfide-bonded, glycoprotein subunits, E170, E145, and E135, based on molecular...

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Veröffentlicht in:Cell 1991-01, Vol.65 (4), p.599-610
Hauptverfasser: Carter, W G, Ryan, M C, Gahr, P J
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epiligrin
integrin
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Ryan, M C
Gahr, P J
description Epiligrin is a new glycoprotein in most epithelial basement membranes and is a ligand for cell adhesion via integrin alpha 3 beta 1. In the extracellular matrix of human foreskin keratinocytes, epiligrin contains three disulfide-bonded, glycoprotein subunits, E170, E145, and E135, based on molecular size in kilodaltons. Epiligrin, immunopurified with MAb P1E1, induced cell adhesion and localization of integrin alpha 3 beta 1 in focal adhesions. Cell adhesion to epiligrin was inhibited with an anti- alpha 3 beta 1 MAb. Epiligrin also colocalized with integrin alpha 6 beta 4 in hemidesmosome-like stable anchoring contacts.
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subjects epiligrin
integrin
title Epiligrin, a new cell adhesion ligand for integrin alpha 3 gamma 1 in epithelial basement membranes
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