An Essential Binding Surface for ShK Toxin Interaction with Rat Brain Potassium Channels

An “Ala scan” analysis of ShK toxin, a 35-residue basic peptide possessing three disulfide bonds, identifies seven side chains which influence binding to brain delayed rectifier potassium channels. Additional analogs were synthesized and tested to further decipher the roles of these residues, partic...

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Veröffentlicht in:	Biochemistry (Easton) 1996-12, Vol.35 (51), p.16407-16411
Hauptverfasser:	Pennington, M. W, Mahnir, V. M, Khaytin, I, Zaydenberg, I, Byrnes, M. E, Kem, W. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Actiniaria Amino Acid Sequence Animals Binding Sites Brain - drug effects Brain - metabolism Cnidarian Venoms - chemical synthesis Cnidarian Venoms - chemistry Cnidarian Venoms - metabolism In Vitro Techniques Marine Membranes - metabolism Models, Molecular Potassium Channel Blockers Potassium Channels - metabolism Protein Conformation Protein Folding Rats Thermodynamics
Online-Zugang:	Volltext
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