Hemostatic changes due to the venom gland extract of the red-necked keelback snake ( Rhabdophis subminiatus)
After a bite by the aglyphous red-necked keelback snake Rhabdophis subminiatus a complete defibrinogenation syndrome with severe hemorrhagic diathesis developed in a 25-year-old man. In vitro studies showed that the venom gland extract of the snake contains a very active prothrombin (Factor II) acti...
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| Veröffentlicht in: | Toxicon (Oxford) 1991, Vol.29 (12), p.1501-1508 |
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| container_title | Toxicon (Oxford) |
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| creator | Zotz, R.B. Mebs, D. Hirche, H. Paar, D. |
| description | After a bite by the aglyphous red-necked keelback snake
Rhabdophis subminiatus a complete defibrinogenation syndrome with severe hemorrhagic diathesis developed in a 25-year-old man.
In vitro studies showed that the venom gland extract of the snake contains a very active prothrombin (Factor II) activator. The thrombin generated is inhibited neither by antithrombin III nor the antithrombin-III-heparin complex. The venom gland extract stimulated also the tissue plasminogen activator; however, it did not cause direct activation of plasminogen, protein C, Factor X or direct degradation of fibrinogen. |
| doi_str_mv | 10.1016/0041-0101(91)90006-D |
| format | Article |
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Rhabdophis subminiatus a complete defibrinogenation syndrome with severe hemorrhagic diathesis developed in a 25-year-old man.
In vitro studies showed that the venom gland extract of the snake contains a very active prothrombin (Factor II) activator. The thrombin generated is inhibited neither by antithrombin III nor the antithrombin-III-heparin complex. The venom gland extract stimulated also the tissue plasminogen activator; however, it did not cause direct activation of plasminogen, protein C, Factor X or direct degradation of fibrinogen.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/0041-0101(91)90006-D</identifier><identifier>PMID: 1801326</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Animal poisons toxicology. Antivenoms ; Animals ; Antithrombin III - pharmacology ; Biological and medical sciences ; Blood Coagulation - drug effects ; Blood Coagulation Tests ; Exocrine Glands - physiology ; Factor X - physiology ; Fibrinogen - metabolism ; Hemorrhage - chemically induced ; Hemorrhage - physiopathology ; Hemostasis - drug effects ; Heparin - pharmacology ; Humans ; Male ; Medical sciences ; Plasminogen - physiology ; Plasminogen Activators - physiology ; Protein C - metabolism ; Snake Bites - physiopathology ; Snakes - physiology ; Tissue Extracts - pharmacology ; Tissue Plasminogen Activator - metabolism ; Toxicology ; Venoms - chemistry</subject><ispartof>Toxicon (Oxford), 1991, Vol.29 (12), p.1501-1508</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-2686bc07f93e1e64cb4bf57a9efc3cd5f89064f98b89b2ec80a52209ddf1ff963</citedby><cites>FETCH-LOGICAL-c417t-2686bc07f93e1e64cb4bf57a9efc3cd5f89064f98b89b2ec80a52209ddf1ff963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0041-0101(91)90006-D$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,4023,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5094131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1801326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zotz, R.B.</creatorcontrib><creatorcontrib>Mebs, D.</creatorcontrib><creatorcontrib>Hirche, H.</creatorcontrib><creatorcontrib>Paar, D.</creatorcontrib><title>Hemostatic changes due to the venom gland extract of the red-necked keelback snake ( Rhabdophis subminiatus)</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>After a bite by the aglyphous red-necked keelback snake
Rhabdophis subminiatus a complete defibrinogenation syndrome with severe hemorrhagic diathesis developed in a 25-year-old man.
In vitro studies showed that the venom gland extract of the snake contains a very active prothrombin (Factor II) activator. The thrombin generated is inhibited neither by antithrombin III nor the antithrombin-III-heparin complex. The venom gland extract stimulated also the tissue plasminogen activator; however, it did not cause direct activation of plasminogen, protein C, Factor X or direct degradation of fibrinogen.</description><subject>Adult</subject><subject>Animal poisons toxicology. Antivenoms</subject><subject>Animals</subject><subject>Antithrombin III - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation - drug effects</subject><subject>Blood Coagulation Tests</subject><subject>Exocrine Glands - physiology</subject><subject>Factor X - physiology</subject><subject>Fibrinogen - metabolism</subject><subject>Hemorrhage - chemically induced</subject><subject>Hemorrhage - physiopathology</subject><subject>Hemostasis - drug effects</subject><subject>Heparin - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Plasminogen - physiology</subject><subject>Plasminogen Activators - physiology</subject><subject>Protein C - metabolism</subject><subject>Snake Bites - physiopathology</subject><subject>Snakes - physiology</subject><subject>Tissue Extracts - pharmacology</subject><subject>Tissue Plasminogen Activator - metabolism</subject><subject>Toxicology</subject><subject>Venoms - chemistry</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN9rFDEQx4Mo9Vr9DxTyINI-rCb7I7d5KUirVigIos8hO5n04u1uzky26H_fnHfUNyGQwPczM5kPY6-keCeFVO-FaGUlyvNcywsthFDV9RO2kv1aV43sxFO2ekSes1Oin4Vpeq1O2InshWxqtWLjDU6Rss0BOGzsfIfE3YI8R543yO9xjhO_G-3sOP7OyULm0f-NErpqRtii41vEcbCw5TTbLfJz_m1jBxd3m0CclmEKc7B5oYsX7Jm3I-HL433Gfnz6-P3qprr9-vnL1YfbClq5zlWtejWAWHvdoETVwtAOvltbjR4acJ3vtVCt1_3Q66FG6IXt6lpo57z0XqvmjL099N2l-GtBymYKBDiWNTAuZKSSQrdNXcD2AEKKRAm92aUw2fTHSGH2ks3eoNkbNLqcvWRzXcpeH_uX5dD9KzpYLfmbY24J7OiTnSHQI9aV4bKRBbs8YFhc3AdMhiDgDOhCQsjGxfD_fzwAYM2YmA</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Zotz, R.B.</creator><creator>Mebs, D.</creator><creator>Hirche, H.</creator><creator>Paar, D.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1991</creationdate><title>Hemostatic changes due to the venom gland extract of the red-necked keelback snake ( Rhabdophis subminiatus)</title><author>Zotz, R.B. ; Mebs, D. ; Hirche, H. ; Paar, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-2686bc07f93e1e64cb4bf57a9efc3cd5f89064f98b89b2ec80a52209ddf1ff963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Animal poisons toxicology. Antivenoms</topic><topic>Animals</topic><topic>Antithrombin III - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation - drug effects</topic><topic>Blood Coagulation Tests</topic><topic>Exocrine Glands - physiology</topic><topic>Factor X - physiology</topic><topic>Fibrinogen - metabolism</topic><topic>Hemorrhage - chemically induced</topic><topic>Hemorrhage - physiopathology</topic><topic>Hemostasis - drug effects</topic><topic>Heparin - pharmacology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Plasminogen - physiology</topic><topic>Plasminogen Activators - physiology</topic><topic>Protein C - metabolism</topic><topic>Snake Bites - physiopathology</topic><topic>Snakes - physiology</topic><topic>Tissue Extracts - pharmacology</topic><topic>Tissue Plasminogen Activator - metabolism</topic><topic>Toxicology</topic><topic>Venoms - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zotz, R.B.</creatorcontrib><creatorcontrib>Mebs, D.</creatorcontrib><creatorcontrib>Hirche, H.</creatorcontrib><creatorcontrib>Paar, D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zotz, R.B.</au><au>Mebs, D.</au><au>Hirche, H.</au><au>Paar, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemostatic changes due to the venom gland extract of the red-necked keelback snake ( Rhabdophis subminiatus)</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>1991</date><risdate>1991</risdate><volume>29</volume><issue>12</issue><spage>1501</spage><epage>1508</epage><pages>1501-1508</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>After a bite by the aglyphous red-necked keelback snake
Rhabdophis subminiatus a complete defibrinogenation syndrome with severe hemorrhagic diathesis developed in a 25-year-old man.
In vitro studies showed that the venom gland extract of the snake contains a very active prothrombin (Factor II) activator. The thrombin generated is inhibited neither by antithrombin III nor the antithrombin-III-heparin complex. The venom gland extract stimulated also the tissue plasminogen activator; however, it did not cause direct activation of plasminogen, protein C, Factor X or direct degradation of fibrinogen.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1801326</pmid><doi>10.1016/0041-0101(91)90006-D</doi><tpages>8</tpages></addata></record> |
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| ispartof | Toxicon (Oxford), 1991, Vol.29 (12), p.1501-1508 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult Animal poisons toxicology. Antivenoms Animals Antithrombin III - pharmacology Biological and medical sciences Blood Coagulation - drug effects Blood Coagulation Tests Exocrine Glands - physiology Factor X - physiology Fibrinogen - metabolism Hemorrhage - chemically induced Hemorrhage - physiopathology Hemostasis - drug effects Heparin - pharmacology Humans Male Medical sciences Plasminogen - physiology Plasminogen Activators - physiology Protein C - metabolism Snake Bites - physiopathology Snakes - physiology Tissue Extracts - pharmacology Tissue Plasminogen Activator - metabolism Toxicology Venoms - chemistry |
| title | Hemostatic changes due to the venom gland extract of the red-necked keelback snake ( Rhabdophis subminiatus) |
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