CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

Inhibition of ceramide synthesis prevents diabetes, steatosis, and cardiovascular disease in rodents. Six different ceramide synthases (CerS) that differ in tissue distribution and substrate specificity account for the diversity in acyl-chain composition of distinct ceramide species. Haploinsufficie...

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Veröffentlicht in:	Cell metabolism 2014-10, Vol.20 (4), p.687-695
Hauptverfasser:	Raichur, Suryaprakash, Wang, Siew Tein, Chan, Puck Wee, Li, Ying, Ching, Jianhong, Chaurasia, Bhagirath, Dogra, Shaillay, Öhman, Miina K., Takeda, Kosuke, Sugii, Shigeki, Pewzner-Jung, Yael, Futerman, Anthony H., Summers, Scott A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight - drug effects Cells, Cultured Ceramides - metabolism Cholesterol, VLDL - blood Diet, High-Fat Electron Transport Chain Complex Proteins - metabolism Fatty Acids, Monounsaturated - pharmacology Fatty Acids, Monounsaturated - therapeutic use Fatty Liver - etiology Fatty Liver - metabolism Fatty Liver - prevention & control HEK293 Cells Hepatocytes - cytology Hepatocytes - metabolism Heterozygote Humans Insulin Resistance Lipid Peroxidation Liver - metabolism Mice PPAR gamma - metabolism Proteins - genetics Proteins - metabolism RNA, Messenger - metabolism Sphingosine N-Acyltransferase - genetics Sphingosine N-Acyltransferase - metabolism
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