Differences in cell-type-specific responses to angiotensin II explain cardiac remodeling differences in C57BL/6 mouse substrains

Despite indications that hearts from the C57BL/6N and C57BL/6J mouse substrains differ in terms of their contractility and their responses to stress-induced overload, no information is available about the underlying molecular and cellular mechanisms. We tested whether subacute (48 hours) and chronic...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-11, Vol.64 (5), p.1040-1046
Hauptverfasser:	Cardin, Sophie, Scott-Boyer, Marie-Pier, Praktiknjo, Samantha, Jeidane, Saloua, Picard, Sylvie, Reudelhuber, Timothy L, Deschepper, Christian F
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - adverse effects Angiotensin II - pharmacology Animals Disease Models, Animal Dose-Response Relationship, Drug Fibroblasts - drug effects Fibroblasts - pathology Fibrosis - chemically induced Fibrosis - metabolism Fibrosis - pathology Galectin 3 - metabolism Heart - drug effects Heart Ventricles - drug effects Heart Ventricles - metabolism Heart Ventricles - pathology Hypertrophy, Left Ventricular - chemically induced Hypertrophy, Left Ventricular - metabolism Hypertrophy, Left Ventricular - pathology In Vitro Techniques Macrophages - drug effects Macrophages - pathology Male Mice Mice, Inbred C57BL - genetics Myocardium - metabolism Myocardium - pathology Osteopontin - metabolism Ventricular Remodeling - drug effects Ventricular Remodeling - physiology
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