The disconnect between a national tuberculosis drug resistance survey and treatment outcomes: a lost opportunity
We linked results from the Fourth Botswana National Drug Resistance Survey (DRS), 2007-2008, to patient records from the national Electronic Tuberculosis Registry to determine treatment outcomes. Of 915 new patients, 651 (71%) had treatment data available. Completion or cure was achieved for 10/15 (...
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Veröffentlicht in: | The international journal of tuberculosis and lung disease 2014-11, Vol.18 (11), p.1319-1322 |
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container_title | The international journal of tuberculosis and lung disease |
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creator | Click, E. S. Chirenda, J. Kibias, S. Menzies, H. J. Oeltmann, J. E. Sentle, C. Muribe, T. Lere, T. D. Makombe, R. Bamrah, S. Moore, B. K. Cain, K. P. |
description | We linked results from the Fourth Botswana National Drug Resistance Survey (DRS), 2007-2008, to patient records from the national Electronic Tuberculosis Registry to determine treatment outcomes. Of 915 new patients, 651 (71%) had treatment data available. Completion or cure was
achieved for 10/15 (67%, 95%CI 42-85) with isoniazid monoresistance, (6/16, 38%, 95%CI 18-61) with multidrug resistance, while 73% (391/537, 95%CI 69-76) were susceptible to first-line drugs. The analysis was limited because of unavailable treatment records and undocumented outcomes. Prospective analyses following DRSs should be considered to ensure adequate outcome data. |
doi_str_mv | 10.5588/ijtld.13.0710 |
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Prospective analyses following DRSs should be considered to ensure adequate outcome data.</description><subject>Antitubercular Agents - pharmacology</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Botswana</subject><subject>Drug</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Isoniazid - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mycobacterium</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Outcome</subject><subject>Pneumology</subject><subject>Registries</subject><subject>Resistance</subject><subject>Retrospective Studies</subject><subject>Survey</subject><subject>Treatment</subject><subject>Treatment Outcome</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Multidrug-Resistant - drug therapy</subject><subject>Tuberculosis, Multidrug-Resistant - microbiology</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksuLFDEQxhtR3HX16FVyEbz0mEenO-1BWNYnLAiynkN1uno2Q08y5rEy_vVmXqseBHNJkfzyVVW-qqrnjC6kVOq1XaV5XDCxoB2jD6pzppisu57ThyWmvKtFx_qz6kmMK0o5Y6x7XJ1xyftetc15tbm5RTLaaLxzaBIZMP1AdASIg2S9g5mkPGAwefbRRjKGvCQBS5jAGSQxhzvcEnAjSQEhrdEl4nMyfo3xTZEpz8rBZuNDys6m7dPq0QRzxGfH_aL69uH9zdWn-vrLx89Xl9e1kapNtREdopH9IBWX2CojBBuwBT6hlA3wQRjFGxgYbcdWjpNBCVMrBzoKhqbh4qJ6e9Dd5GGNoyl1BZj1Jtg1hK32YPXfN87e6qW_07IXTMiuCLw6CgT_PWNMel2-CecZHPocNWtF3_etpPI_UEa7lqu-L2h9QE3wMQac7itiVO8M1XtDNRN6Z2jhX_zZxj19crAAL48ARAPzFIotNv7mlFK06UTh3h0465alY9Arn0OxN2qbYZfxkJdT1mi6X0ydAqYhpH1QZL7-S8aclHZjt5s6fceUK495mTtabNSskUqPOEGek04Q9PKnjkX0F-2S3yg</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Click, E. 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subjects | Antitubercular Agents - pharmacology Bacterial diseases Biological and medical sciences Botswana Drug Female Follow-Up Studies Human bacterial diseases Humans Infectious diseases Isoniazid - pharmacology Male Medical sciences Mycobacterium Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - isolation & purification Outcome Pneumology Registries Resistance Retrospective Studies Survey Treatment Treatment Outcome Tuberculosis and atypical mycobacterial infections Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology |
title | The disconnect between a national tuberculosis drug resistance survey and treatment outcomes: a lost opportunity |
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