The disconnect between a national tuberculosis drug resistance survey and treatment outcomes: a lost opportunity

We linked results from the Fourth Botswana National Drug Resistance Survey (DRS), 2007-2008, to patient records from the national Electronic Tuberculosis Registry to determine treatment outcomes. Of 915 new patients, 651 (71%) had treatment data available. Completion or cure was achieved for 10/15 (...

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Veröffentlicht in:The international journal of tuberculosis and lung disease 2014-11, Vol.18 (11), p.1319-1322
Hauptverfasser: Click, E. S., Chirenda, J., Kibias, S., Menzies, H. J., Oeltmann, J. E., Sentle, C., Muribe, T., Lere, T. D., Makombe, R., Bamrah, S., Moore, B. K., Cain, K. P.
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container_end_page 1322
container_issue 11
container_start_page 1319
container_title The international journal of tuberculosis and lung disease
container_volume 18
creator Click, E. S.
Chirenda, J.
Kibias, S.
Menzies, H. J.
Oeltmann, J. E.
Sentle, C.
Muribe, T.
Lere, T. D.
Makombe, R.
Bamrah, S.
Moore, B. K.
Cain, K. P.
description We linked results from the Fourth Botswana National Drug Resistance Survey (DRS), 2007-2008, to patient records from the national Electronic Tuberculosis Registry to determine treatment outcomes. Of 915 new patients, 651 (71%) had treatment data available. Completion or cure was achieved for 10/15 (67%, 95%CI 42-85) with isoniazid monoresistance, (6/16, 38%, 95%CI 18-61) with multidrug resistance, while 73% (391/537, 95%CI 69-76) were susceptible to first-line drugs. The analysis was limited because of unavailable treatment records and undocumented outcomes. Prospective analyses following DRSs should be considered to ensure adequate outcome data.
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subjects Antitubercular Agents - pharmacology
Bacterial diseases
Biological and medical sciences
Botswana
Drug
Female
Follow-Up Studies
Human bacterial diseases
Humans
Infectious diseases
Isoniazid - pharmacology
Male
Medical sciences
Mycobacterium
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - isolation & purification
Outcome
Pneumology
Registries
Resistance
Retrospective Studies
Survey
Treatment
Treatment Outcome
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - microbiology
title The disconnect between a national tuberculosis drug resistance survey and treatment outcomes: a lost opportunity
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