Sevoflurane/propofol coadministration provides better recovery than sevoflurane in combined general/epidural anesthesia: a randomized clinical trial
Purpose A classic general anesthesia is performed by induction with an intravenous hypnotic (such as propofol) and maintenance with a volatile anesthetic (such as sevoflurane). The aim of the present study was to compare the effects of a propofol/sevoflurane maintenance regimen with that of a sevofl...
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| Veröffentlicht in: | Journal of anesthesia 2014-10, Vol.28 (5), p.721-726 |
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| creator | Liang, Chao Ding, Ming Du, Fang Cang, Jing Xue, Zhanggang |
| description | Purpose
A classic general anesthesia is performed by induction with an intravenous hypnotic (such as propofol) and maintenance with a volatile anesthetic (such as sevoflurane). The aim of the present study was to compare the effects of a propofol/sevoflurane maintenance regimen with that of a sevoflurane regimen on recovery profiles.
Methods
One hundred and sixty patients, who were ASA 1 or 2, 45–65 years of age, and scheduled for elective gastrointestinal surgery under combined general/epidural anesthesia, were allocated randomly to receive the sevoflurane maintenance regimen (group S,
n
= 80) or sevoflurane/propofol regimen (group SP,
n
= 80). After induction, anesthesia was maintained with sevoflurane in group S and sevoflurane with propofol (1.2 μg/ml target plasma concentration) in group SP. Bispectral index (BIS) values were maintained within 40–60 during the maintenance. Time to extubation, incidence of serious coughing and agitation, and other recovery characteristics were evaluated during emergence.
Results
The time to awakening and extubation in group SP were 7.2 ± 2 min and 8.0 ± 1.8 min, respectively, which were shorter than those results in group S (12.3 ± 1.5 and 12.8 ± 1.6 min, respectively) (
P
|
| doi_str_mv | 10.1007/s00540-014-1803-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1610759217</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A386744834</galeid><sourcerecordid>A386744834</sourcerecordid><originalsourceid>FETCH-LOGICAL-c609t-614cf36c297ac9b42234c8c16738cb0e21707c687b8e27f0c97441b0c48efc13</originalsourceid><addsrcrecordid>eNp9ks9q3DAQxk1pabZpH6CXIuilF2dHlmzJvYXQfxDoobkLWR5vFGxpK9kL6XP0gTuLty2Fpegg0Py-TzPDVxSvOVxxALXNALWEErgsuQZRwpNiw6XQpRZ1-7TYQMtFqZtGXxQvcn4AgIZz8by4qGRdK9BqU_z8hoc4jEuyAbf7FPdxiCNz0faTDz7Pyc4-BkaVg-8xsw7nGRNL6OIB0yOb721g-a8H84HUU-cD9myHAZMdt7j3PVVHRkCe7zF7-55ZRnwfJ_-DSDfSb46IOXk7viyeDXbM-Op0XxZ3Hz_c3Xwub79--nJzfVu6Btq5bLh0g2hc1Srr2k5WlZBOO94ooV0HWHEFyjVadRorNYBrlZS8Ayc1Do6Ly-LdakvTfV-oMzP57HAcqc24ZMMbDqpuyYbQtyu6syMaH4ZIm3FH3FwL3ZCvFpKo8gx12kIMOHh6_oe_OsPT6XHy7qyArwKXYs4JB7NPfrLp0XAwx0iYNRKGImGOkTBAmjenKZduwv6P4ncGCKhWIFMp7DCZh7ikQIv_j-svYQrDOw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1610759217</pqid></control><display><type>article</type><title>Sevoflurane/propofol coadministration provides better recovery than sevoflurane in combined general/epidural anesthesia: a randomized clinical trial</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Liang, Chao ; Ding, Ming ; Du, Fang ; Cang, Jing ; Xue, Zhanggang</creator><creatorcontrib>Liang, Chao ; Ding, Ming ; Du, Fang ; Cang, Jing ; Xue, Zhanggang</creatorcontrib><description>Purpose
A classic general anesthesia is performed by induction with an intravenous hypnotic (such as propofol) and maintenance with a volatile anesthetic (such as sevoflurane). The aim of the present study was to compare the effects of a propofol/sevoflurane maintenance regimen with that of a sevoflurane regimen on recovery profiles.
Methods
One hundred and sixty patients, who were ASA 1 or 2, 45–65 years of age, and scheduled for elective gastrointestinal surgery under combined general/epidural anesthesia, were allocated randomly to receive the sevoflurane maintenance regimen (group S,
n
= 80) or sevoflurane/propofol regimen (group SP,
n
= 80). After induction, anesthesia was maintained with sevoflurane in group S and sevoflurane with propofol (1.2 μg/ml target plasma concentration) in group SP. Bispectral index (BIS) values were maintained within 40–60 during the maintenance. Time to extubation, incidence of serious coughing and agitation, and other recovery characteristics were evaluated during emergence.
Results
The time to awakening and extubation in group SP were 7.2 ± 2 min and 8.0 ± 1.8 min, respectively, which were shorter than those results in group S (12.3 ± 1.5 and 12.8 ± 1.6 min, respectively) (
P
< 0.05). The incidence of serious coughing and agitation in SP (30 % and 25 %) was lower than that of group S (68 % and 53 %) (
P
< 0.05). BIS value, pain score, requirements of analgesics and antiemetics in the PACU, and length of stay in the PACU were similar in the two groups.
Conclusions
Compared to sevoflurane maintenance, coadministration of propofol and sevoflurane provides faster awakening and extubation with a low incidence of emergence coughing and agitation.</description><identifier>ISSN: 0913-8668</identifier><identifier>EISSN: 1438-8359</identifier><identifier>DOI: 10.1007/s00540-014-1803-0</identifier><identifier>PMID: 24557087</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Aged ; Analgesics ; Analysis ; Anesthesia Recovery Period ; Anesthesia, Epidural - methods ; Anesthesia, General - methods ; Anesthesiology ; Anesthetics, Inhalation - administration & dosage ; Clinical trials ; Critical Care Medicine ; Digestive System Surgical Procedures - methods ; Double-Blind Method ; Elective Surgical Procedures - methods ; Emergency Medicine ; Female ; Humans ; Intensive ; Male ; Medicine ; Medicine & Public Health ; Methyl Ethers - administration & dosage ; Middle Aged ; Original Article ; Pain Medicine ; Peridural anesthesia ; Propofol - administration & dosage ; Prospective Studies</subject><ispartof>Journal of anesthesia, 2014-10, Vol.28 (5), p.721-726</ispartof><rights>Japanese Society of Anesthesiologists 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-614cf36c297ac9b42234c8c16738cb0e21707c687b8e27f0c97441b0c48efc13</citedby><cites>FETCH-LOGICAL-c609t-614cf36c297ac9b42234c8c16738cb0e21707c687b8e27f0c97441b0c48efc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00540-014-1803-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00540-014-1803-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24557087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Chao</creatorcontrib><creatorcontrib>Ding, Ming</creatorcontrib><creatorcontrib>Du, Fang</creatorcontrib><creatorcontrib>Cang, Jing</creatorcontrib><creatorcontrib>Xue, Zhanggang</creatorcontrib><title>Sevoflurane/propofol coadministration provides better recovery than sevoflurane in combined general/epidural anesthesia: a randomized clinical trial</title><title>Journal of anesthesia</title><addtitle>J Anesth</addtitle><addtitle>J Anesth</addtitle><description>Purpose
A classic general anesthesia is performed by induction with an intravenous hypnotic (such as propofol) and maintenance with a volatile anesthetic (such as sevoflurane). The aim of the present study was to compare the effects of a propofol/sevoflurane maintenance regimen with that of a sevoflurane regimen on recovery profiles.
Methods
One hundred and sixty patients, who were ASA 1 or 2, 45–65 years of age, and scheduled for elective gastrointestinal surgery under combined general/epidural anesthesia, were allocated randomly to receive the sevoflurane maintenance regimen (group S,
n
= 80) or sevoflurane/propofol regimen (group SP,
n
= 80). After induction, anesthesia was maintained with sevoflurane in group S and sevoflurane with propofol (1.2 μg/ml target plasma concentration) in group SP. Bispectral index (BIS) values were maintained within 40–60 during the maintenance. Time to extubation, incidence of serious coughing and agitation, and other recovery characteristics were evaluated during emergence.
Results
The time to awakening and extubation in group SP were 7.2 ± 2 min and 8.0 ± 1.8 min, respectively, which were shorter than those results in group S (12.3 ± 1.5 and 12.8 ± 1.6 min, respectively) (
P
< 0.05). The incidence of serious coughing and agitation in SP (30 % and 25 %) was lower than that of group S (68 % and 53 %) (
P
< 0.05). BIS value, pain score, requirements of analgesics and antiemetics in the PACU, and length of stay in the PACU were similar in the two groups.
Conclusions
Compared to sevoflurane maintenance, coadministration of propofol and sevoflurane provides faster awakening and extubation with a low incidence of emergence coughing and agitation.</description><subject>Aged</subject><subject>Analgesics</subject><subject>Analysis</subject><subject>Anesthesia Recovery Period</subject><subject>Anesthesia, Epidural - methods</subject><subject>Anesthesia, General - methods</subject><subject>Anesthesiology</subject><subject>Anesthetics, Inhalation - administration & dosage</subject><subject>Clinical trials</subject><subject>Critical Care Medicine</subject><subject>Digestive System Surgical Procedures - methods</subject><subject>Double-Blind Method</subject><subject>Elective Surgical Procedures - methods</subject><subject>Emergency Medicine</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methyl Ethers - administration & dosage</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Peridural anesthesia</subject><subject>Propofol - administration & dosage</subject><subject>Prospective Studies</subject><issn>0913-8668</issn><issn>1438-8359</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks9q3DAQxk1pabZpH6CXIuilF2dHlmzJvYXQfxDoobkLWR5vFGxpK9kL6XP0gTuLty2Fpegg0Py-TzPDVxSvOVxxALXNALWEErgsuQZRwpNiw6XQpRZ1-7TYQMtFqZtGXxQvcn4AgIZz8by4qGRdK9BqU_z8hoc4jEuyAbf7FPdxiCNz0faTDz7Pyc4-BkaVg-8xsw7nGRNL6OIB0yOb721g-a8H84HUU-cD9myHAZMdt7j3PVVHRkCe7zF7-55ZRnwfJ_-DSDfSb46IOXk7viyeDXbM-Op0XxZ3Hz_c3Xwub79--nJzfVu6Btq5bLh0g2hc1Srr2k5WlZBOO94ooV0HWHEFyjVadRorNYBrlZS8Ayc1Do6Ly-LdakvTfV-oMzP57HAcqc24ZMMbDqpuyYbQtyu6syMaH4ZIm3FH3FwL3ZCvFpKo8gx12kIMOHh6_oe_OsPT6XHy7qyArwKXYs4JB7NPfrLp0XAwx0iYNRKGImGOkTBAmjenKZduwv6P4ncGCKhWIFMp7DCZh7ikQIv_j-svYQrDOw</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Liang, Chao</creator><creator>Ding, Ming</creator><creator>Du, Fang</creator><creator>Cang, Jing</creator><creator>Xue, Zhanggang</creator><general>Springer Japan</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>Sevoflurane/propofol coadministration provides better recovery than sevoflurane in combined general/epidural anesthesia: a randomized clinical trial</title><author>Liang, Chao ; Ding, Ming ; Du, Fang ; Cang, Jing ; Xue, Zhanggang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-614cf36c297ac9b42234c8c16738cb0e21707c687b8e27f0c97441b0c48efc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Analgesics</topic><topic>Analysis</topic><topic>Anesthesia Recovery Period</topic><topic>Anesthesia, Epidural - methods</topic><topic>Anesthesia, General - methods</topic><topic>Anesthesiology</topic><topic>Anesthetics, Inhalation - administration & dosage</topic><topic>Clinical trials</topic><topic>Critical Care Medicine</topic><topic>Digestive System Surgical Procedures - methods</topic><topic>Double-Blind Method</topic><topic>Elective Surgical Procedures - methods</topic><topic>Emergency Medicine</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methyl Ethers - administration & dosage</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Peridural anesthesia</topic><topic>Propofol - administration & dosage</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Chao</creatorcontrib><creatorcontrib>Ding, Ming</creatorcontrib><creatorcontrib>Du, Fang</creatorcontrib><creatorcontrib>Cang, Jing</creatorcontrib><creatorcontrib>Xue, Zhanggang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Chao</au><au>Ding, Ming</au><au>Du, Fang</au><au>Cang, Jing</au><au>Xue, Zhanggang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sevoflurane/propofol coadministration provides better recovery than sevoflurane in combined general/epidural anesthesia: a randomized clinical trial</atitle><jtitle>Journal of anesthesia</jtitle><stitle>J Anesth</stitle><addtitle>J Anesth</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>28</volume><issue>5</issue><spage>721</spage><epage>726</epage><pages>721-726</pages><issn>0913-8668</issn><eissn>1438-8359</eissn><abstract>Purpose
A classic general anesthesia is performed by induction with an intravenous hypnotic (such as propofol) and maintenance with a volatile anesthetic (such as sevoflurane). The aim of the present study was to compare the effects of a propofol/sevoflurane maintenance regimen with that of a sevoflurane regimen on recovery profiles.
Methods
One hundred and sixty patients, who were ASA 1 or 2, 45–65 years of age, and scheduled for elective gastrointestinal surgery under combined general/epidural anesthesia, were allocated randomly to receive the sevoflurane maintenance regimen (group S,
n
= 80) or sevoflurane/propofol regimen (group SP,
n
= 80). After induction, anesthesia was maintained with sevoflurane in group S and sevoflurane with propofol (1.2 μg/ml target plasma concentration) in group SP. Bispectral index (BIS) values were maintained within 40–60 during the maintenance. Time to extubation, incidence of serious coughing and agitation, and other recovery characteristics were evaluated during emergence.
Results
The time to awakening and extubation in group SP were 7.2 ± 2 min and 8.0 ± 1.8 min, respectively, which were shorter than those results in group S (12.3 ± 1.5 and 12.8 ± 1.6 min, respectively) (
P
< 0.05). The incidence of serious coughing and agitation in SP (30 % and 25 %) was lower than that of group S (68 % and 53 %) (
P
< 0.05). BIS value, pain score, requirements of analgesics and antiemetics in the PACU, and length of stay in the PACU were similar in the two groups.
Conclusions
Compared to sevoflurane maintenance, coadministration of propofol and sevoflurane provides faster awakening and extubation with a low incidence of emergence coughing and agitation.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24557087</pmid><doi>10.1007/s00540-014-1803-0</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0913-8668 |
| ispartof | Journal of anesthesia, 2014-10, Vol.28 (5), p.721-726 |
| issn | 0913-8668 1438-8359 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Analgesics Analysis Anesthesia Recovery Period Anesthesia, Epidural - methods Anesthesia, General - methods Anesthesiology Anesthetics, Inhalation - administration & dosage Clinical trials Critical Care Medicine Digestive System Surgical Procedures - methods Double-Blind Method Elective Surgical Procedures - methods Emergency Medicine Female Humans Intensive Male Medicine Medicine & Public Health Methyl Ethers - administration & dosage Middle Aged Original Article Pain Medicine Peridural anesthesia Propofol - administration & dosage Prospective Studies |
| title | Sevoflurane/propofol coadministration provides better recovery than sevoflurane in combined general/epidural anesthesia: a randomized clinical trial |
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