Thioaryl Naphthylmethanone Oxime Ether Analogs as Novel Anticancer Agents

Employing a rational design of thioaryl naphthylmethanone oxime ether analogs containing functional properties of various anticancer drugs, a series of compounds were identified that displayed potent cytotoxicity toward various cancer cells, out of which 4-(methylthio)phenyl)(naphthalen-1-yl)methano...

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Veröffentlicht in:	Journal of medicinal chemistry 2014-10, Vol.57 (19), p.8010-8025
Hauptverfasser:	Chakravarti, Bandana, Akhtar, Tahseen, Rai, Byanju, Yadav, Manisha, Akhtar Siddiqui, Jawed, Dhar Dwivedi, Shailendra Kumar, Thakur, Ravi, Singh, Anup Kumar, Singh, Abhishek Kumar, Kumar, Harish, Khan, Kainat, Pal, Subhashis, Rath, Srikanta Kumar, Lal, Jawahar, Konwar, Rituraj, Trivedi, Arun Kumar, Datta, Dipak, Mishra, Durga Prasad, Godbole, Madan Madhav, Sanyal, Sabyasachi, Chattopadhyay, Naibedya, Kumar, Atul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Apoptosis - drug effects Benzhydryl Compounds - chemical synthesis Benzhydryl Compounds - pharmacology Cell Cycle - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Humans Mice Neoplasm Invasiveness Neoplastic Stem Cells - drug effects Oximes - chemical synthesis Oximes - pharmacology Receptor, Epidermal Growth Factor - physiology Signal Transduction - physiology Structure-Activity Relationship
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