The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene
The Tg737 gene was investigated for gross alterations in a series of rodent/human liver tumors and human tumorigenic cell lines. The Tg737 gene was found to be altered in approximately 40% of the rodent chemically-induced liver tumors, 40% of the human liver tumors, and in liver, kidney and pancreat...
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| Veröffentlicht in: | Oncogene 1997-10, Vol.15 (15), p.1797-1803 |
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| creator | ISFORT, R. J CODY, D. B WOYCHIK, R. P DOERSEN, C.-J RICHARDS, W. G YODER, B. K WILKINSON, J. E KIER, L. D JIRTLE, R. L ISENBERG, J. S KLOUNIG, J. E |
| description | The Tg737 gene was investigated for gross alterations in a series of rodent/human liver tumors and human tumorigenic cell lines. The Tg737 gene was found to be altered in approximately 40% of the rodent chemically-induced liver tumors, 40% of the human liver tumors, and in liver, kidney and pancreatic human tumor cell lines. Ectopic re-expression of the Tg737 gene in a Tg737 deleted mouse liver tumor cell line resulted in suppression of tumorigenic growth, without altering in vitro cell culture growth. Treatment of mice which are either homozygous normal or heterozygous deleted at the Tg737 locus with the carcinogen diethylnitrosamine resulted in an increase in preneoplastic foci formation in the Tg737 heterozygous deleted mice. Ectopic expression of the Tg737 gene results in multinucleated cells, loss of Tg737 gene expression results in the proliferation of liver stem cells (oval cells) without concomitant differentiation, and reexpression of the Tg737 gene reestablished responsiveness to external differentiation factors. We believe this is the first report demonstrating tumor suppression activity for a tetratricopeptide repeat gene family member and provides insights into the function of this family of genes in mammalian cells. |
| doi_str_mv | 10.1038/sj.onc.1201535 |
| format | Article |
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J ; CODY, D. B ; WOYCHIK, R. P ; DOERSEN, C.-J ; RICHARDS, W. G ; YODER, B. K ; WILKINSON, J. E ; KIER, L. D ; JIRTLE, R. L ; ISENBERG, J. S ; KLOUNIG, J. E</creator><creatorcontrib>ISFORT, R. J ; CODY, D. B ; WOYCHIK, R. P ; DOERSEN, C.-J ; RICHARDS, W. G ; YODER, B. K ; WILKINSON, J. E ; KIER, L. D ; JIRTLE, R. L ; ISENBERG, J. S ; KLOUNIG, J. E</creatorcontrib><description>The Tg737 gene was investigated for gross alterations in a series of rodent/human liver tumors and human tumorigenic cell lines. The Tg737 gene was found to be altered in approximately 40% of the rodent chemically-induced liver tumors, 40% of the human liver tumors, and in liver, kidney and pancreatic human tumor cell lines. Ectopic re-expression of the Tg737 gene in a Tg737 deleted mouse liver tumor cell line resulted in suppression of tumorigenic growth, without altering in vitro cell culture growth. Treatment of mice which are either homozygous normal or heterozygous deleted at the Tg737 locus with the carcinogen diethylnitrosamine resulted in an increase in preneoplastic foci formation in the Tg737 heterozygous deleted mice. Ectopic expression of the Tg737 gene results in multinucleated cells, loss of Tg737 gene expression results in the proliferation of liver stem cells (oval cells) without concomitant differentiation, and reexpression of the Tg737 gene reestablished responsiveness to external differentiation factors. We believe this is the first report demonstrating tumor suppression activity for a tetratricopeptide repeat gene family member and provides insights into the function of this family of genes in mammalian cells.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1201535</identifier><identifier>PMID: 9362446</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Animals ; Biological and medical sciences ; Carcinogens ; Cell culture ; Cell differentiation ; Cell Division - genetics ; Cell physiology ; Cell proliferation ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Diethylnitrosamine ; Ectopic expression ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Genes, Tumor Suppressor ; Hepatocytes ; Heterozygote ; Homozygote ; Humans ; Kidneys ; Liver ; Liver cancer ; Liver Neoplasms, Experimental - genetics ; Liver Neoplasms, Experimental - pathology ; Male ; Mammalian cells ; Mice ; Mice, Inbred C3H ; Molecular and cellular biology ; Peptides - chemistry ; Peptides - genetics ; Proteins - genetics ; Stem cell transplantation ; Stem cells ; Tumor cell lines ; Tumor suppressor genes ; Tumor Suppressor Proteins ; Tumors</subject><ispartof>Oncogene, 1997-10, Vol.15 (15), p.1797-1803</ispartof><rights>1997 INIST-CNRS</rights><rights>Macmillan Publishers Limited 1997.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-690f108837cd79852d2c61fa57f38a04a2a58dc4869d43323284327530358b663</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2855216$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9362446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ISFORT, R. J</creatorcontrib><creatorcontrib>CODY, D. B</creatorcontrib><creatorcontrib>WOYCHIK, R. P</creatorcontrib><creatorcontrib>DOERSEN, C.-J</creatorcontrib><creatorcontrib>RICHARDS, W. G</creatorcontrib><creatorcontrib>YODER, B. K</creatorcontrib><creatorcontrib>WILKINSON, J. E</creatorcontrib><creatorcontrib>KIER, L. D</creatorcontrib><creatorcontrib>JIRTLE, R. L</creatorcontrib><creatorcontrib>ISENBERG, J. S</creatorcontrib><creatorcontrib>KLOUNIG, J. E</creatorcontrib><title>The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene</title><title>Oncogene</title><addtitle>Oncogene</addtitle><description>The Tg737 gene was investigated for gross alterations in a series of rodent/human liver tumors and human tumorigenic cell lines. The Tg737 gene was found to be altered in approximately 40% of the rodent chemically-induced liver tumors, 40% of the human liver tumors, and in liver, kidney and pancreatic human tumor cell lines. Ectopic re-expression of the Tg737 gene in a Tg737 deleted mouse liver tumor cell line resulted in suppression of tumorigenic growth, without altering in vitro cell culture growth. Treatment of mice which are either homozygous normal or heterozygous deleted at the Tg737 locus with the carcinogen diethylnitrosamine resulted in an increase in preneoplastic foci formation in the Tg737 heterozygous deleted mice. Ectopic expression of the Tg737 gene results in multinucleated cells, loss of Tg737 gene expression results in the proliferation of liver stem cells (oval cells) without concomitant differentiation, and reexpression of the Tg737 gene reestablished responsiveness to external differentiation factors. 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Psychology</subject><subject>Gene expression</subject><subject>Genes, Tumor Suppressor</subject><subject>Hepatocytes</subject><subject>Heterozygote</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Kidneys</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms, Experimental - genetics</subject><subject>Liver Neoplasms, Experimental - pathology</subject><subject>Male</subject><subject>Mammalian cells</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Molecular and cellular biology</subject><subject>Peptides - chemistry</subject><subject>Peptides - genetics</subject><subject>Proteins - genetics</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Tumor cell lines</subject><subject>Tumor suppressor genes</subject><subject>Tumor Suppressor Proteins</subject><subject>Tumors</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1rGzEQxUVJcRy319wCgpTe1tX3Ssdg0qZg6MU9FiFrta7Menej0Rby31fGiw85zcD7zePNQ-iekjUlXH-D43ro_ZoyQiWXH9CSilpVUhpxg5bESFIZxtktugM4EkJqQ9gCLQxXTAi1RH92fwPOISeXU_TDGMYcm4BTGIPL2A99drGP_QHvDjWv8SH0AUfADnfxX0i4D8PYOYgO5-k0JAzTOKYAUNYz-gl9bF0H4fM8V-j39-fd5qXa_vrxc_O0rbygOlfKkJYSrXntm9poyRrmFW2drFuuHRGOOakbL7QyjeC8_KMFZ7XkhEu9V4qv0NeL75iG1ylAtqcIPnSdKwEnsFRRwow-g4_vwOMwpb5ks0wJyooj44VaXyifBoAUWjumeHLpzVJiz61bONrSup1bLwcPs-20P4Xmis81F_3LrDvwrmuT632EK8a0lIwq_h9GE4kj</recordid><startdate>19971009</startdate><enddate>19971009</enddate><creator>ISFORT, R. 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Ectopic re-expression of the Tg737 gene in a Tg737 deleted mouse liver tumor cell line resulted in suppression of tumorigenic growth, without altering in vitro cell culture growth. Treatment of mice which are either homozygous normal or heterozygous deleted at the Tg737 locus with the carcinogen diethylnitrosamine resulted in an increase in preneoplastic foci formation in the Tg737 heterozygous deleted mice. Ectopic expression of the Tg737 gene results in multinucleated cells, loss of Tg737 gene expression results in the proliferation of liver stem cells (oval cells) without concomitant differentiation, and reexpression of the Tg737 gene reestablished responsiveness to external differentiation factors. 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| subjects | Animals Biological and medical sciences Carcinogens Cell culture Cell differentiation Cell Division - genetics Cell physiology Cell proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Diethylnitrosamine Ectopic expression Fundamental and applied biological sciences. Psychology Gene expression Genes, Tumor Suppressor Hepatocytes Heterozygote Homozygote Humans Kidneys Liver Liver cancer Liver Neoplasms, Experimental - genetics Liver Neoplasms, Experimental - pathology Male Mammalian cells Mice Mice, Inbred C3H Molecular and cellular biology Peptides - chemistry Peptides - genetics Proteins - genetics Stem cell transplantation Stem cells Tumor cell lines Tumor suppressor genes Tumor Suppressor Proteins Tumors |
| title | The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene |
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