Pharmacokinetics of Ochratoxin A and Its Metabolites in Rats

Ochratoxin A (OA) is a mycotoxin that is produced on moist grain. It is commonly found in the blood of swine in western Canada and is a potent nephrotoxic, carcinogen, and immunosuppressive agent. The pharmacokinetic characteristics of six analogs of OA including OA, OB (OA without chloride), OC (OA...

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Veröffentlicht in:	Toxicology and applied pharmacology 1997-07, Vol.145 (1), p.82-90
Hauptverfasser:	Li, S., Marquardt, R.R., Frohlich, A.A., Vitti, T.G., Crow, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	ANALOGS Animals BILE Bile - metabolism BILIS Biological and medical sciences Biotransformation BLOOD CHEMISTRY BLOOD COMPOSITION Carcinogens - administration & dosage Carcinogens - chemistry Carcinogens - pharmacokinetics Chromatography, High Pressure Liquid CLEARANCE COMPOSICION DE LA SANGRE COMPOSITION DU SANG Dose-Response Relationship, Drug EXCRECION EXCRETION FARMACOLOGIA Female FONCTION PHYSIOLOGIQUE FUNCION FISIOLOGICA HALF LIFE INJECTION Injections, Intravenous INTRAVENOUS INJECTION INYECCION KIDNEYS Medical sciences METABOLISM METABOLISME METABOLISMO METABOLITE METABOLITES METABOLITOS Mycotoxins - administration & dosage Mycotoxins - chemistry Mycotoxins - pharmacokinetics OCHRATOXIN OCHRATOXINE Ochratoxins - administration & dosage Ochratoxins - chemistry Ochratoxins - pharmacokinetics OCRATOXINA PHARMACOLOGIE PHARMACOLOGY PHYSIOLOGICAL FUNCTIONS Plant poisons toxicology RAT RATA RATS Rats, Sprague-Dawley REIN RINONES Structure-Activity Relationship Tissue Distribution Toxicology Tracheotomy
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