Inhibition of evoked neurotransmitter release from rat hippocampus by a polypeptide toxin isolated from the marine snail Conus distans
The active fraction, isolated and partially purified from the crude venom of the marine snail Conus distans, with a molecular mass of about 25 kDa, inhibits neurotransmitter release in rat hippocampus. This toxin (distans Toxin) inhibits the electrically evoked tritium labelled noradrenaline release...
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| Veröffentlicht in: | Neurochemistry international 1992, Vol.20 (1), p.69-74 |
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| container_title | Neurochemistry international |
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| creator | Saxena, V.K. Partoens, P. de Block, J. Coen, E.P. Vauquelin, G. De Potter, W.P. |
| description | The active fraction, isolated and partially purified from the crude venom of the marine snail
Conus distans, with a molecular mass of about 25 kDa, inhibits neurotransmitter release in rat hippocampus.
This toxin (distans Toxin) inhibits the electrically evoked tritium labelled noradrenaline release from rat hippocampal slices in a dose and time dependent manner. The neurotransmitter release is mainly regulated by N-type of voltage sensitive Ca
2+-channels.
The distans toxin behaves as a partial antagonist of calcium in the buffer, possibly by competing with calcium for this type of voltage sensitive Ca
2+-channels. |
| doi_str_mv | 10.1016/0197-0186(92)90127-D |
| format | Article |
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Conus distans, with a molecular mass of about 25 kDa, inhibits neurotransmitter release in rat hippocampus.
This toxin (distans Toxin) inhibits the electrically evoked tritium labelled noradrenaline release from rat hippocampal slices in a dose and time dependent manner. The neurotransmitter release is mainly regulated by N-type of voltage sensitive Ca
2+-channels.
The distans toxin behaves as a partial antagonist of calcium in the buffer, possibly by competing with calcium for this type of voltage sensitive Ca
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Conus distans, with a molecular mass of about 25 kDa, inhibits neurotransmitter release in rat hippocampus.
This toxin (distans Toxin) inhibits the electrically evoked tritium labelled noradrenaline release from rat hippocampal slices in a dose and time dependent manner. The neurotransmitter release is mainly regulated by N-type of voltage sensitive Ca
2+-channels.
The distans toxin behaves as a partial antagonist of calcium in the buffer, possibly by competing with calcium for this type of voltage sensitive Ca
2+-channels.</description><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Calcium - pharmacology</subject><subject>Central nervous system</subject><subject>Chromatography, Gel</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. 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Conus distans, with a molecular mass of about 25 kDa, inhibits neurotransmitter release in rat hippocampus.
This toxin (distans Toxin) inhibits the electrically evoked tritium labelled noradrenaline release from rat hippocampal slices in a dose and time dependent manner. The neurotransmitter release is mainly regulated by N-type of voltage sensitive Ca
2+-channels.
The distans toxin behaves as a partial antagonist of calcium in the buffer, possibly by competing with calcium for this type of voltage sensitive Ca
2+-channels.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1304320</pmid><doi>10.1016/0197-0186(92)90127-D</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-0186 |
| ispartof | Neurochemistry international, 1992, Vol.20 (1), p.69-74 |
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| subjects | Animals Biochemistry and metabolism Biological and medical sciences Calcium - pharmacology Central nervous system Chromatography, Gel Dose-Response Relationship, Drug Electric Stimulation Female Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiology In Vitro Techniques Kinetics Male Mollusk Venoms - isolation & purification Mollusk Venoms - pharmacology Neurotoxins - pharmacology Norepinephrine - metabolism Rats Snails Vertebrates: nervous system and sense organs |
| title | Inhibition of evoked neurotransmitter release from rat hippocampus by a polypeptide toxin isolated from the marine snail Conus distans |
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