Chromosomal and genetic alterations of 7,12- Dimethylbenz[a]anthracene-induced melanoma from TP-ras transgenic mice

The TP‐ras transgenic mouse line expresses an activated human T24 Ha‐ras gene with a mutation in codon 12, regulated by a mouse tyrosinase promoter. The transgene is expressed in melanocytes of the skin, eyes, and brain. The mice develop cutaneous melanoma when treated with 7,12‐dimethylbenz[a]anthr...

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