Cytochrome P450 Metabolism of Estradiol in Hamster Liver and Kidney

Estradiol induces kidney tumors in Syrian hamsters. The elevated conversion of estradiol to 4-hydroxylated metabolites in kidney compared to the predominant 2-hydroxylation in liver and other organs, where tumors are not induced by this treatment, has been proposed to be the basis of estrogen-induce...

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Veröffentlicht in:	Toxicology and applied pharmacology 1997-07, Vol.145 (1), p.54-60
Hauptverfasser:	Hammond, Dianne K., Zhu, Bao Ting, Wang, Mian Y., Ricci, Mary Jo, Liehr, Joachim G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases beta-Naphthoflavone - administration & dosage beta-Naphthoflavone - metabolism beta-Naphthoflavone - toxicity Biological and medical sciences Blotting, Western Cricetinae Cytochrome P-450 CYP1A1 - biosynthesis Cytochrome P-450 CYP1A2 - biosynthesis Cytochrome P-450 CYP1B1 Cytochrome P-450 Enzyme System - metabolism Drug toxicity and drugs side effects treatment Enzyme Induction - drug effects Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - metabolism Enzyme Inhibitors - toxicity Estradiol - administration & dosage Estradiol - metabolism Estradiol - toxicity Hydroxylation Kidney - drug effects Kidney - enzymology Male Medical sciences Mesocricetus Microsomes - drug effects Microsomes - enzymology Microsomes, Liver - drug effects Microsomes, Liver - enzymology Miscellaneous (drug allergy, mutagens, teratogens...) NADP - metabolism Pharmacology. Drug treatments Software Steroid Hydroxylases - metabolism
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