Role of CYP3A in Ethanol-Mediated Increases in Acetaminophen Hepatotoxicity

CYP2E is considered the only form of cytochrome P450 responsible for ethanol-mediated increases in acetaminophen hepatotoxicity. However, in experimental systems used for investigating ethanol-mediated increases in acetaminophen hepatotoxicity, animals are withdrawn from ethanol for 16 to 24 hr befo...

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Veröffentlicht in:	Toxicology and applied pharmacology 1997-04, Vol.143 (2), p.315-323
Hauptverfasser:	Kostrubsky, Vsevolod E., Szakacs, Juliana G., Jeffery, Elizabeth H., Wood, Sheryl G., Bement, William J., Wrighton, Steven A., Sinclair, Peter R., Sinclair, Jacqueline F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - toxicity Analgesics, Non-Narcotic - toxicity Animals Anti-Bacterial Agents - pharmacology Aryl Hydrocarbon Hydroxylases Biological and medical sciences Central Nervous System Depressants - pharmacology Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - pathology Cytochrome P-450 CYP2E1 - biosynthesis Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - biosynthesis Drug Administration Schedule Drug Interactions Drug toxicity and drugs side effects treatment Enzyme Induction - drug effects Ethanol - pharmacology Liver - drug effects Liver - enzymology Liver - pathology Male Medical sciences Oxidoreductases, N-Demethylating - antagonists & inhibitors Oxidoreductases, N-Demethylating - biosynthesis Pharmacology. Drug treatments Rats Rats, Inbred F344 Toxicity: digestive system Troleandomycin - pharmacology
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