Reduction of seizure frequency by clonazepam during cobalt experimental epilepsy
Adult female Sprague-Dawley rats rendered epileptic by bilateral cerebral implantation of cobalt wire were simultaneously prepared with permanent cortical and temporalis muscle electrodes for continuous recording of electroencephalographic (EEG) and electromyographic (EMG) activities. Clonazepam (4,...
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| Veröffentlicht in: | Brain research bulletin 1992-02, Vol.28 (2), p.329-331 |
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| creator | Colasanti, Brenda K. Craig, Charles R. |
| description | Adult female Sprague-Dawley rats rendered epileptic by bilateral cerebral implantation of cobalt wire were simultaneously prepared with permanent cortical and temporalis muscle electrodes for continuous recording of electroencephalographic (EEG) and electromyographic (EMG) activities. Clonazepam (4, 10 or 40 mg/kg) dissolved in gum acacia was administered once daily intraperitoneally for 5 days beginning 9 days after cobalt implantation. The 40 mg/kg dose completely suppressed generalized seizure activity. Although no tolerance to this effect developed by the fifth day of treatment, generalized seizure activity two days after the last injection was significantly greater in epileptic rats than in control animals. These results suggest that the cobalt model of epilepsy may be useful in the study of mechanisms underlying both anticonvulsant effectiveness and rebound excitability after anticonvulsant drug withdrawal. |
| doi_str_mv | 10.1016/0361-9230(92)90197-6 |
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Clonazepam (4, 10 or 40 mg/kg) dissolved in gum acacia was administered once daily intraperitoneally for 5 days beginning 9 days after cobalt implantation. The 40 mg/kg dose completely suppressed generalized seizure activity. Although no tolerance to this effect developed by the fifth day of treatment, generalized seizure activity two days after the last injection was significantly greater in epileptic rats than in control animals. These results suggest that the cobalt model of epilepsy may be useful in the study of mechanisms underlying both anticonvulsant effectiveness and rebound excitability after anticonvulsant drug withdrawal.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/0361-9230(92)90197-6</identifier><identifier>PMID: 1596753</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Clonazepam ; Clonazepam - therapeutic use ; Cobalt - toxicity ; Cobalt epilepsy ; Dose-Response Relationship, Drug ; EEG ; Electroencephalography ; Epilepsy - chemically induced ; Epilepsy - physiopathology ; Epilepsy - prevention & control ; Female ; Medical sciences ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Rat ; Rats ; Rats, Inbred Strains ; Seizures ; Seizures - physiopathology ; Seizures - prevention & control</subject><ispartof>Brain research bulletin, 1992-02, Vol.28 (2), p.329-331</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-31e76fb1f5eea69542a73f75d6ea496304fa06b2da87307ccfc78f13bf7f98433</citedby><cites>FETCH-LOGICAL-c417t-31e76fb1f5eea69542a73f75d6ea496304fa06b2da87307ccfc78f13bf7f98433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0361923092901976$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5078472$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1596753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colasanti, Brenda K.</creatorcontrib><creatorcontrib>Craig, Charles R.</creatorcontrib><title>Reduction of seizure frequency by clonazepam during cobalt experimental epilepsy</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>Adult female Sprague-Dawley rats rendered epileptic by bilateral cerebral implantation of cobalt wire were simultaneously prepared with permanent cortical and temporalis muscle electrodes for continuous recording of electroencephalographic (EEG) and electromyographic (EMG) activities. Clonazepam (4, 10 or 40 mg/kg) dissolved in gum acacia was administered once daily intraperitoneally for 5 days beginning 9 days after cobalt implantation. The 40 mg/kg dose completely suppressed generalized seizure activity. Although no tolerance to this effect developed by the fifth day of treatment, generalized seizure activity two days after the last injection was significantly greater in epileptic rats than in control animals. These results suggest that the cobalt model of epilepsy may be useful in the study of mechanisms underlying both anticonvulsant effectiveness and rebound excitability after anticonvulsant drug withdrawal.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Clonazepam</subject><subject>Clonazepam - therapeutic use</subject><subject>Cobalt - toxicity</subject><subject>Cobalt epilepsy</subject><subject>Dose-Response Relationship, Drug</subject><subject>EEG</subject><subject>Electroencephalography</subject><subject>Epilepsy - chemically induced</subject><subject>Epilepsy - physiopathology</subject><subject>Epilepsy - prevention & control</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Seizures</subject><subject>Seizures - physiopathology</subject><subject>Seizures - prevention & control</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KxDAURoMo4zj6BgpZiOiimjRt0m4EGfyDAUV0HdL0RiKdtiat2Hl6U2cYd26SxT3347sHoWNKLimh_IowTqM8ZuQ8jy9yQnMR8R00pZlgUSwSsYumW2QfHXj_QQjhWconaELTnIuUTdHzC5S97mxT48ZgD3bVO8DGwWcPtR5wMWBdNbVaQauWuOydrd-xbgpVdRi-W3B2CXWnKgytraD1wyHaM6rycLT5Z-jt7vZ1_hAtnu4f5zeLSCdUdBGjILgpqEkBFM_TJFaCGZGWHFSSc0YSowgv4lKFc4jQ2miRGcoKI0yeJYzN0Nk6t3VN6Oo7ubReQ1WpGpreS8qDpDFphpI1qF3jvQMj21BauUFSIkeRcrQkR0vhkb8i5bh2ssnviyWUf0trc2F-upkrr1VlnKq19VssJSJLRByw6zUGwcWXBSe9tsEslNaB7mTZ2P97_ADfxI_p</recordid><startdate>19920201</startdate><enddate>19920201</enddate><creator>Colasanti, Brenda K.</creator><creator>Craig, Charles R.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19920201</creationdate><title>Reduction of seizure frequency by clonazepam during cobalt experimental epilepsy</title><author>Colasanti, Brenda K. ; Craig, Charles R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-31e76fb1f5eea69542a73f75d6ea496304fa06b2da87307ccfc78f13bf7f98433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Clonazepam</topic><topic>Clonazepam - therapeutic use</topic><topic>Cobalt - toxicity</topic><topic>Cobalt epilepsy</topic><topic>Dose-Response Relationship, Drug</topic><topic>EEG</topic><topic>Electroencephalography</topic><topic>Epilepsy - chemically induced</topic><topic>Epilepsy - physiopathology</topic><topic>Epilepsy - prevention & control</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Seizures</topic><topic>Seizures - physiopathology</topic><topic>Seizures - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colasanti, Brenda K.</creatorcontrib><creatorcontrib>Craig, Charles R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colasanti, Brenda K.</au><au>Craig, Charles R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction of seizure frequency by clonazepam during cobalt experimental epilepsy</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1992-02-01</date><risdate>1992</risdate><volume>28</volume><issue>2</issue><spage>329</spage><epage>331</epage><pages>329-331</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>Adult female Sprague-Dawley rats rendered epileptic by bilateral cerebral implantation of cobalt wire were simultaneously prepared with permanent cortical and temporalis muscle electrodes for continuous recording of electroencephalographic (EEG) and electromyographic (EMG) activities. Clonazepam (4, 10 or 40 mg/kg) dissolved in gum acacia was administered once daily intraperitoneally for 5 days beginning 9 days after cobalt implantation. The 40 mg/kg dose completely suppressed generalized seizure activity. Although no tolerance to this effect developed by the fifth day of treatment, generalized seizure activity two days after the last injection was significantly greater in epileptic rats than in control animals. These results suggest that the cobalt model of epilepsy may be useful in the study of mechanisms underlying both anticonvulsant effectiveness and rebound excitability after anticonvulsant drug withdrawal.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1596753</pmid><doi>10.1016/0361-9230(92)90197-6</doi><tpages>3</tpages></addata></record> |
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| ispartof | Brain research bulletin, 1992-02, Vol.28 (2), p.329-331 |
| issn | 0361-9230 1873-2747 |
| language | eng |
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| subjects | Animals Biological and medical sciences Clonazepam Clonazepam - therapeutic use Cobalt - toxicity Cobalt epilepsy Dose-Response Relationship, Drug EEG Electroencephalography Epilepsy - chemically induced Epilepsy - physiopathology Epilepsy - prevention & control Female Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Rat Rats Rats, Inbred Strains Seizures Seizures - physiopathology Seizures - prevention & control |
| title | Reduction of seizure frequency by clonazepam during cobalt experimental epilepsy |
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