(A-C-B) human proinsulin, a novel insulin agonist and intermediate in the synthesis of biosynthetic human insulin

The hormone insulin is synthesized in the beta cell of the pancreas as the precursor, proinsulin, where the carboxyl terminus of the B-chain is connected to the amino terminus of the A-chain by a connecting or C-peptide. Proinsulin is a weak insulin agonist that possesses a longer in vivo half-life...

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Veröffentlicht in:	The Journal of biological chemistry 1992-01, Vol.267 (1), p.419-425
Hauptverfasser:	Heath, W F, Belagaje, R M, Brooke, G S, Chance, R E, Hoffmann, J A, Long, H B, Reams, S G, Roundtree, C, Shaw, W N, Slieker, L J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Base Sequence Biological and medical sciences Blotting, Western Chromatography, High Pressure Liquid Cloning, Molecular Electrophoresis, Polyacrylamide Gel Escherichia coli Escherichia coli - genetics Fundamental and applied biological sciences. Psychology Genes, Bacterial Humans Hypoglycemia - chemically induced insulin Insulin - metabolism Male Molecular Sequence Data Peptide Mapping Placenta - metabolism Plasmids Proinsulin - biosynthesis Proinsulin - chemistry Proinsulin - genetics Protein Conformation Protein hormones. Growth factors. Cytokines Proteins Rats Rats, Inbred Strains Receptor, Insulin - metabolism Sulfhydryl Compounds - metabolism Transformation, Genetic
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