Mutations in Drosophila DP and E2F distinguish G sub(1)-S progression from an associated transcriptional program

The E2F transcription factor, a heterodimer of E2F and DP subunits, is capable of driving the G sub(1)-S transition of the cell cycle. However, mice in which the E2F-1 gene had been disrupted developed tumors, suggesting a negative role for E2F in controlling cell proliferation in some tissues. The...

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Veröffentlicht in:	Genes & development 1997-08, Vol.11 (15), p.1999-2011
Hauptverfasser:	Royzman, I, Whittaker, A J, Orr-Weaver, T L
Format:	Artikel
Sprache:	eng
Schlagworte:	Drosophila
Online-Zugang:	Volltext
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