Reactive oxygen species involvement in ricin-induced thyroid toxicity in rat
1 Ricin is known to have diverse effects on the cells of different organs like liver, kidney, pancreas, intestines and parathyroid. 2 Acute decrease in serum thyroid hormone levels 24 h after ricin administration (1.5 μg/100 g) led us to suspect the toxic action of ricin on the thyroid. 3 We monitor...
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| Veröffentlicht in: | Human & experimental toxicology 1997-05, Vol.16 (5), p.254-256 |
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| container_title | Human & experimental toxicology |
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| creator | Sadani, Geeta R Soman, Chitralekha S Deodhar, Kedar K Nadkarni, Ganeshsunder D |
| description | 1 Ricin is known to have diverse effects on the cells of different organs like liver, kidney, pancreas, intestines and parathyroid.
2 Acute decrease in serum thyroid hormone levels 24 h after ricin administration (1.5 μg/100 g) led us to suspect the toxic action of ricin on the thyroid.
3 We monitored the lipid peroxidation (LP) and anti oxidant status of the thyroid tissue to determine the role, if any, played by reactive oxygen species (ROS) in this pathology.
4 An increase of 39% in LP and 47% in superoxide dismutase, along with a 8.5% decrease in catalase
points to the imbalance in the antioxidant defence involving hydrogen peroxide and its univalent reduc tion product, the hydroxyl radical.
5 Thyroid histopathology shows destruction of thyroid follicles and necrosis, which may be due to ROS and may partly explain the 50% reduction in circulating thyroid hormones seen after ricin administration. |
| doi_str_mv | 10.1177/096032719701600503 |
| format | Article |
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2 Acute decrease in serum thyroid hormone levels 24 h after ricin administration (1.5 μg/100 g) led us to suspect the toxic action of ricin on the thyroid.
3 We monitored the lipid peroxidation (LP) and anti oxidant status of the thyroid tissue to determine the role, if any, played by reactive oxygen species (ROS) in this pathology.
4 An increase of 39% in LP and 47% in superoxide dismutase, along with a 8.5% decrease in catalase
points to the imbalance in the antioxidant defence involving hydrogen peroxide and its univalent reduc tion product, the hydroxyl radical.
5 Thyroid histopathology shows destruction of thyroid follicles and necrosis, which may be due to ROS and may partly explain the 50% reduction in circulating thyroid hormones seen after ricin administration.</description><identifier>ISSN: 0960-3271</identifier><identifier>ISSN: 0144-5952</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/096032719701600503</identifier><identifier>PMID: 9192203</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Catalase - metabolism ; Female ; Lipid Peroxidation ; Medical sciences ; Plant poisons toxicology ; Rats ; Rats, Wistar ; Reactive Oxygen Species - metabolism ; Ricin - toxicity ; Ricinus communis ; Superoxide Dismutase - metabolism ; Thyroid Gland - drug effects ; Thyroid Gland - metabolism ; Thyroid Gland - pathology ; Thyroxine - blood ; Toxicology ; Triiodothyronine - blood</subject><ispartof>Human & experimental toxicology, 1997-05, Vol.16 (5), p.254-256</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-97d8d51a6acc2bd789fd781e29800b1360181f0e48ad2731f95b37810806e8893</citedby><cites>FETCH-LOGICAL-c398t-97d8d51a6acc2bd789fd781e29800b1360181f0e48ad2731f95b37810806e8893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096032719701600503$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096032719701600503$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2713539$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9192203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sadani, Geeta R</creatorcontrib><creatorcontrib>Soman, Chitralekha S</creatorcontrib><creatorcontrib>Deodhar, Kedar K</creatorcontrib><creatorcontrib>Nadkarni, Ganeshsunder D</creatorcontrib><title>Reactive oxygen species involvement in ricin-induced thyroid toxicity in rat</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>1 Ricin is known to have diverse effects on the cells of different organs like liver, kidney, pancreas, intestines and parathyroid.
2 Acute decrease in serum thyroid hormone levels 24 h after ricin administration (1.5 μg/100 g) led us to suspect the toxic action of ricin on the thyroid.
3 We monitored the lipid peroxidation (LP) and anti oxidant status of the thyroid tissue to determine the role, if any, played by reactive oxygen species (ROS) in this pathology.
4 An increase of 39% in LP and 47% in superoxide dismutase, along with a 8.5% decrease in catalase
points to the imbalance in the antioxidant defence involving hydrogen peroxide and its univalent reduc tion product, the hydroxyl radical.
5 Thyroid histopathology shows destruction of thyroid follicles and necrosis, which may be due to ROS and may partly explain the 50% reduction in circulating thyroid hormones seen after ricin administration.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Catalase - metabolism</subject><subject>Female</subject><subject>Lipid Peroxidation</subject><subject>Medical sciences</subject><subject>Plant poisons toxicology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Ricin - toxicity</subject><subject>Ricinus communis</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroxine - blood</subject><subject>Toxicology</subject><subject>Triiodothyronine - blood</subject><issn>0960-3271</issn><issn>0144-5952</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gCDsQbytnSTdTXKU4hcUBNHzkmZna8p-1GS3dP-9qV16EbxkQuaZd8JDyDWFe0qFmIJKgTNBlQCaAiTAT8iYzoSIQQE_JeM9EO-Jc3Lh_RoAUpXQERkpqhgDPiaLd9SmtVuMml2_wjryGzQWfWTrbVNuscK6DffIWWPr2NZ5ZzCP2q_eNTbUZhfe2_6X0O0lOSt06fFqqBPy-fT4MX-JF2_Pr_OHRWy4km2sRC7zhOpUG8OWuZCqCAdFpiTAkvIUqKQF4EzqnAlOC5UseQBAQopSKj4hd4fcjWu-O_RtVllvsCx1jU3nsyBDJYyxALIDaFzjvcMi2zhbaddnFLK9wuyvwjB0M6R3ywrz48jgLPRvh772RpeF07Wx_oiFMJ7w_SenB8zrFWbrpnN1cPLf4h9XOYUC</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Sadani, Geeta R</creator><creator>Soman, Chitralekha S</creator><creator>Deodhar, Kedar K</creator><creator>Nadkarni, Ganeshsunder D</creator><general>SAGE Publications</general><general>Arnold</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19970501</creationdate><title>Reactive oxygen species involvement in ricin-induced thyroid toxicity in rat</title><author>Sadani, Geeta R ; Soman, Chitralekha S ; Deodhar, Kedar K ; Nadkarni, Ganeshsunder D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-97d8d51a6acc2bd789fd781e29800b1360181f0e48ad2731f95b37810806e8893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Catalase - metabolism</topic><topic>Female</topic><topic>Lipid Peroxidation</topic><topic>Medical sciences</topic><topic>Plant poisons toxicology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Ricin - toxicity</topic><topic>Ricinus communis</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroxine - blood</topic><topic>Toxicology</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sadani, Geeta R</creatorcontrib><creatorcontrib>Soman, Chitralekha S</creatorcontrib><creatorcontrib>Deodhar, Kedar K</creatorcontrib><creatorcontrib>Nadkarni, Ganeshsunder D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sadani, Geeta R</au><au>Soman, Chitralekha S</au><au>Deodhar, Kedar K</au><au>Nadkarni, Ganeshsunder D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reactive oxygen species involvement in ricin-induced thyroid toxicity in rat</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>16</volume><issue>5</issue><spage>254</spage><epage>256</epage><pages>254-256</pages><issn>0960-3271</issn><issn>0144-5952</issn><eissn>1477-0903</eissn><abstract>1 Ricin is known to have diverse effects on the cells of different organs like liver, kidney, pancreas, intestines and parathyroid.
2 Acute decrease in serum thyroid hormone levels 24 h after ricin administration (1.5 μg/100 g) led us to suspect the toxic action of ricin on the thyroid.
3 We monitored the lipid peroxidation (LP) and anti oxidant status of the thyroid tissue to determine the role, if any, played by reactive oxygen species (ROS) in this pathology.
4 An increase of 39% in LP and 47% in superoxide dismutase, along with a 8.5% decrease in catalase
points to the imbalance in the antioxidant defence involving hydrogen peroxide and its univalent reduc tion product, the hydroxyl radical.
5 Thyroid histopathology shows destruction of thyroid follicles and necrosis, which may be due to ROS and may partly explain the 50% reduction in circulating thyroid hormones seen after ricin administration.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>9192203</pmid><doi>10.1177/096032719701600503</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; SAGE Complete A-Z List; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Catalase - metabolism Female Lipid Peroxidation Medical sciences Plant poisons toxicology Rats Rats, Wistar Reactive Oxygen Species - metabolism Ricin - toxicity Ricinus communis Superoxide Dismutase - metabolism Thyroid Gland - drug effects Thyroid Gland - metabolism Thyroid Gland - pathology Thyroxine - blood Toxicology Triiodothyronine - blood |
| title | Reactive oxygen species involvement in ricin-induced thyroid toxicity in rat |
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