Myelodysplastic syndromes

Summary Myelodysplastic syndromes are clonal marrow stem-cell disorders, characterised by ineffective haemopoiesis leading to blood cytopenias, and by progression to acute myeloid leukaemia in a third of patients. 15% of cases occur after chemotherapy or radiotherapy for a previous cancer; the syndr...

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Veröffentlicht in:	The Lancet (British edition) 2014-06, Vol.383 (9936), p.2239-2252
Hauptverfasser:	Adès, Lionel, MD, Itzykson, Raphael, MD, Fenaux, Pierre, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Apoptosis Biological and medical sciences Blood Bone marrow Chemotherapy Clinical outcomes Cytogenetic Analysis Cytogenetics Diagnosis, Differential Epigenesis, Genetic - genetics Epigenetics Gene expression General aspects Genotype & phenotype Growth factors Hematologic and hematopoietic diseases Hematopoiesis - physiology Humans Internal Medicine Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical prognosis Medical sciences Mutation Mutation - genetics Myelodysplastic syndromes Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - etiology Myelodysplastic Syndromes - therapy Older people Prognosis Stem Cell Transplantation - methods T-Lymphocytes - physiology Transplants & implants Treatment Outcome Tumors
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