Long-term Survival After Pancreatic Resection for Renal Cell Carcinoma Metastasis
Background Surgical resection of pancreatic metastasis (PM) is the only reported curative treatment for renal cell carcinoma. However, there is currently little information regarding very long-term survival. The primary objective of this study was to determine the 10-year survival of this condition...
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| Veröffentlicht in: | Annals of surgical oncology 2014-11, Vol.21 (12), p.4007-4013 |
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| container_title | Annals of surgical oncology |
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| creator | Schwarz, L. Sauvanet, A. Regenet, N. Mabrut, J. Y. Gigot, J. F. Housseau, E. Millat, B. Ouaissi, M. Gayet, B. Fuks, D. Tuech, J. J. |
| description | Background
Surgical resection of pancreatic metastasis (PM) is the only reported curative treatment for renal cell carcinoma. However, there is currently little information regarding very long-term survival. The primary objective of this study was to determine the 10-year survival of this condition using the largest surgical series reported to date.
Methods
Between May 1987 and June 2003, we conducted a retrospective study of 62 patients surgically treated for PM from renal cell carcinoma at 12 Franco-Belgian surgical centers. Follow-up ended on May 31, 2012.
Results
There were 27 male (44 %) and 35 female (56 %) patients with a median age of 54 years [31–75]. Mean disease-free interval from resection of primary tumor to reoperation for pancreatic recurrence was 9.8 years (median 10 years [0–25]). During a median follow-up of 91 months [12–250], 37 recurrences (60 %) were observed. After surgical resection of repeated recurrences, overall median survival time was 52.6 months versus 11.2 months after nonoperative management (
p
= 0.019). Cumulative 3-, 5-, and 10-year overall survival (OS) rates were 72, 63, and 32 %, respectively. The corresponding disease-free survival rates were 54, 35, and 27 %, respectively. Lymph node involvement and existence of extrapancreatic metastases before PM were associated with poor overall survival.
Conclusions
Aggressive surgical management of single or multiple PM, even in cases of extrapancreatic disease, should be considered in selected patients to allow a chance of long-term survival. |
| doi_str_mv | 10.1245/s10434-014-3821-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1609505346</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3454167721</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-5b9a883a44fe34d8847617fbef074ec361bfbe5ed0f7651c2841eb37984508873</originalsourceid><addsrcrecordid>eNp1kF1LwzAUhoMobk5_gDdS8MabatIkTXo5hl8w8fs6pNnJ6FjbmbSC_94jnSKCEJLzJs95k7yEHDN6zjIhLyKjgouUMpFynbFU7JAxk7gjcs12saa5TosslyNyEOOKUqY4lftklAmtCqmLMXmct80y7SDUyXMf3qt3u06mHnXyYBsXwHaVS54gguuqtkl8G1A1CM1gjZMNrmra2iZ30NmIo4qHZM_bdYSj7Tohr1eXL7ObdH5_fTubzlMnqOxSWRZWa26F8MDFQmuhcqZ8CZ4qAY7nrEQhYUG9yiVzmRYMSq4KLSTVWvEJORt8N6F96yF2pq6iw1fZBto-GpbTQlJMI0f09A-6avuAvxgoKrWSFCk2UC60MQbwZhOq2oYPw6j5ytsMeRvM23zlbQT2nGyd-7KGxU_Hd8AIZAMQ8ahZQvh19b-un4NLiVk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1609058750</pqid></control><display><type>article</type><title>Long-term Survival After Pancreatic Resection for Renal Cell Carcinoma Metastasis</title><source>MEDLINE</source><source>SpringerNature Complete Journals</source><creator>Schwarz, L. ; Sauvanet, A. ; Regenet, N. ; Mabrut, J. Y. ; Gigot, J. F. ; Housseau, E. ; Millat, B. ; Ouaissi, M. ; Gayet, B. ; Fuks, D. ; Tuech, J. J.</creator><creatorcontrib>Schwarz, L. ; Sauvanet, A. ; Regenet, N. ; Mabrut, J. Y. ; Gigot, J. F. ; Housseau, E. ; Millat, B. ; Ouaissi, M. ; Gayet, B. ; Fuks, D. ; Tuech, J. J.</creatorcontrib><description>Background
Surgical resection of pancreatic metastasis (PM) is the only reported curative treatment for renal cell carcinoma. However, there is currently little information regarding very long-term survival. The primary objective of this study was to determine the 10-year survival of this condition using the largest surgical series reported to date.
Methods
Between May 1987 and June 2003, we conducted a retrospective study of 62 patients surgically treated for PM from renal cell carcinoma at 12 Franco-Belgian surgical centers. Follow-up ended on May 31, 2012.
Results
There were 27 male (44 %) and 35 female (56 %) patients with a median age of 54 years [31–75]. Mean disease-free interval from resection of primary tumor to reoperation for pancreatic recurrence was 9.8 years (median 10 years [0–25]). During a median follow-up of 91 months [12–250], 37 recurrences (60 %) were observed. After surgical resection of repeated recurrences, overall median survival time was 52.6 months versus 11.2 months after nonoperative management (
p
= 0.019). Cumulative 3-, 5-, and 10-year overall survival (OS) rates were 72, 63, and 32 %, respectively. The corresponding disease-free survival rates were 54, 35, and 27 %, respectively. Lymph node involvement and existence of extrapancreatic metastases before PM were associated with poor overall survival.
Conclusions
Aggressive surgical management of single or multiple PM, even in cases of extrapancreatic disease, should be considered in selected patients to allow a chance of long-term survival.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-014-3821-4</identifier><identifier>PMID: 24879589</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Aged ; Carcinoma, Papillary - mortality ; Carcinoma, Papillary - pathology ; Carcinoma, Papillary - surgery ; Carcinoma, Renal Cell - mortality ; Carcinoma, Renal Cell - pathology ; Carcinoma, Renal Cell - surgery ; Female ; Follow-Up Studies ; Humans ; Kidney Neoplasms - mortality ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; Neoplasm Staging ; Oncology ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - secondary ; Pancreatic Neoplasms - surgery ; Pancreatic Tumors ; Prognosis ; Retrospective Studies ; Surgery ; Surgical Oncology ; Survival Rate</subject><ispartof>Annals of surgical oncology, 2014-11, Vol.21 (12), p.4007-4013</ispartof><rights>Society of Surgical Oncology 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-5b9a883a44fe34d8847617fbef074ec361bfbe5ed0f7651c2841eb37984508873</citedby><cites>FETCH-LOGICAL-c405t-5b9a883a44fe34d8847617fbef074ec361bfbe5ed0f7651c2841eb37984508873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-014-3821-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-014-3821-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24879589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwarz, L.</creatorcontrib><creatorcontrib>Sauvanet, A.</creatorcontrib><creatorcontrib>Regenet, N.</creatorcontrib><creatorcontrib>Mabrut, J. Y.</creatorcontrib><creatorcontrib>Gigot, J. F.</creatorcontrib><creatorcontrib>Housseau, E.</creatorcontrib><creatorcontrib>Millat, B.</creatorcontrib><creatorcontrib>Ouaissi, M.</creatorcontrib><creatorcontrib>Gayet, B.</creatorcontrib><creatorcontrib>Fuks, D.</creatorcontrib><creatorcontrib>Tuech, J. J.</creatorcontrib><title>Long-term Survival After Pancreatic Resection for Renal Cell Carcinoma Metastasis</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Surgical resection of pancreatic metastasis (PM) is the only reported curative treatment for renal cell carcinoma. However, there is currently little information regarding very long-term survival. The primary objective of this study was to determine the 10-year survival of this condition using the largest surgical series reported to date.
Methods
Between May 1987 and June 2003, we conducted a retrospective study of 62 patients surgically treated for PM from renal cell carcinoma at 12 Franco-Belgian surgical centers. Follow-up ended on May 31, 2012.
Results
There were 27 male (44 %) and 35 female (56 %) patients with a median age of 54 years [31–75]. Mean disease-free interval from resection of primary tumor to reoperation for pancreatic recurrence was 9.8 years (median 10 years [0–25]). During a median follow-up of 91 months [12–250], 37 recurrences (60 %) were observed. After surgical resection of repeated recurrences, overall median survival time was 52.6 months versus 11.2 months after nonoperative management (
p
= 0.019). Cumulative 3-, 5-, and 10-year overall survival (OS) rates were 72, 63, and 32 %, respectively. The corresponding disease-free survival rates were 54, 35, and 27 %, respectively. Lymph node involvement and existence of extrapancreatic metastases before PM were associated with poor overall survival.
Conclusions
Aggressive surgical management of single or multiple PM, even in cases of extrapancreatic disease, should be considered in selected patients to allow a chance of long-term survival.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Papillary - mortality</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Carcinoma, Renal Cell - mortality</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Carcinoma, Renal Cell - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Kidney Neoplasms - mortality</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - secondary</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Pancreatic Tumors</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kF1LwzAUhoMobk5_gDdS8MabatIkTXo5hl8w8fs6pNnJ6FjbmbSC_94jnSKCEJLzJs95k7yEHDN6zjIhLyKjgouUMpFynbFU7JAxk7gjcs12saa5TosslyNyEOOKUqY4lftklAmtCqmLMXmct80y7SDUyXMf3qt3u06mHnXyYBsXwHaVS54gguuqtkl8G1A1CM1gjZMNrmra2iZ30NmIo4qHZM_bdYSj7Tohr1eXL7ObdH5_fTubzlMnqOxSWRZWa26F8MDFQmuhcqZ8CZ4qAY7nrEQhYUG9yiVzmRYMSq4KLSTVWvEJORt8N6F96yF2pq6iw1fZBto-GpbTQlJMI0f09A-6avuAvxgoKrWSFCk2UC60MQbwZhOq2oYPw6j5ytsMeRvM23zlbQT2nGyd-7KGxU_Hd8AIZAMQ8ahZQvh19b-un4NLiVk</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Schwarz, L.</creator><creator>Sauvanet, A.</creator><creator>Regenet, N.</creator><creator>Mabrut, J. Y.</creator><creator>Gigot, J. F.</creator><creator>Housseau, E.</creator><creator>Millat, B.</creator><creator>Ouaissi, M.</creator><creator>Gayet, B.</creator><creator>Fuks, D.</creator><creator>Tuech, J. J.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20141101</creationdate><title>Long-term Survival After Pancreatic Resection for Renal Cell Carcinoma Metastasis</title><author>Schwarz, L. ; Sauvanet, A. ; Regenet, N. ; Mabrut, J. Y. ; Gigot, J. F. ; Housseau, E. ; Millat, B. ; Ouaissi, M. ; Gayet, B. ; Fuks, D. ; Tuech, J. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-5b9a883a44fe34d8847617fbef074ec361bfbe5ed0f7651c2841eb37984508873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Papillary - mortality</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Carcinoma, Renal Cell - mortality</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Carcinoma, Renal Cell - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Kidney Neoplasms - mortality</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - secondary</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Pancreatic Tumors</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwarz, L.</creatorcontrib><creatorcontrib>Sauvanet, A.</creatorcontrib><creatorcontrib>Regenet, N.</creatorcontrib><creatorcontrib>Mabrut, J. Y.</creatorcontrib><creatorcontrib>Gigot, J. F.</creatorcontrib><creatorcontrib>Housseau, E.</creatorcontrib><creatorcontrib>Millat, B.</creatorcontrib><creatorcontrib>Ouaissi, M.</creatorcontrib><creatorcontrib>Gayet, B.</creatorcontrib><creatorcontrib>Fuks, D.</creatorcontrib><creatorcontrib>Tuech, J. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwarz, L.</au><au>Sauvanet, A.</au><au>Regenet, N.</au><au>Mabrut, J. Y.</au><au>Gigot, J. F.</au><au>Housseau, E.</au><au>Millat, B.</au><au>Ouaissi, M.</au><au>Gayet, B.</au><au>Fuks, D.</au><au>Tuech, J. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term Survival After Pancreatic Resection for Renal Cell Carcinoma Metastasis</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>21</volume><issue>12</issue><spage>4007</spage><epage>4013</epage><pages>4007-4013</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Surgical resection of pancreatic metastasis (PM) is the only reported curative treatment for renal cell carcinoma. However, there is currently little information regarding very long-term survival. The primary objective of this study was to determine the 10-year survival of this condition using the largest surgical series reported to date.
Methods
Between May 1987 and June 2003, we conducted a retrospective study of 62 patients surgically treated for PM from renal cell carcinoma at 12 Franco-Belgian surgical centers. Follow-up ended on May 31, 2012.
Results
There were 27 male (44 %) and 35 female (56 %) patients with a median age of 54 years [31–75]. Mean disease-free interval from resection of primary tumor to reoperation for pancreatic recurrence was 9.8 years (median 10 years [0–25]). During a median follow-up of 91 months [12–250], 37 recurrences (60 %) were observed. After surgical resection of repeated recurrences, overall median survival time was 52.6 months versus 11.2 months after nonoperative management (
p
= 0.019). Cumulative 3-, 5-, and 10-year overall survival (OS) rates were 72, 63, and 32 %, respectively. The corresponding disease-free survival rates were 54, 35, and 27 %, respectively. Lymph node involvement and existence of extrapancreatic metastases before PM were associated with poor overall survival.
Conclusions
Aggressive surgical management of single or multiple PM, even in cases of extrapancreatic disease, should be considered in selected patients to allow a chance of long-term survival.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24879589</pmid><doi>10.1245/s10434-014-3821-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Carcinoma, Papillary - mortality Carcinoma, Papillary - pathology Carcinoma, Papillary - surgery Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - surgery Female Follow-Up Studies Humans Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kidney Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Neoplasm Staging Oncology Pancreatic Neoplasms - mortality Pancreatic Neoplasms - secondary Pancreatic Neoplasms - surgery Pancreatic Tumors Prognosis Retrospective Studies Surgery Surgical Oncology Survival Rate |
| title | Long-term Survival After Pancreatic Resection for Renal Cell Carcinoma Metastasis |
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