Human small‐cell lung‐cancer cells are cytokine‐resistant but NK/LAK‐sensitive

We have studied the effects of 8 cytokines and their combinations on the in vitro growth of 10 human small‐cell cancer lines (SCLC). Interferon‐α and γ (IFN‐α and γ) caused significant but slight growth inhibition over a 7‐day incubation period. However, none of the other 6 cytokines, tumor necrosis...

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Veröffentlicht in:	International journal of cancer 1991-05, Vol.48 (2), p.311-317
Hauptverfasser:	Lagadec, Patricia F., Saraya, Khaled A., Balkwill, Frances R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Blotting, Northern Carcinoma, Small Cell - chemistry Carcinoma, Small Cell - immunology Carcinoma, Small Cell - therapy Cell Division - drug effects Cell Division - immunology Cytokines - genetics Cytokines - pharmacology Cytotoxicity Tests, Immunologic Humans Immunotherapy Interferon-gamma - pharmacology Killer Cells, Lymphokine-Activated - immunology Killer Cells, Natural - immunology Lung Neoplasms - chemistry Lung Neoplasms - immunology Lung Neoplasms - therapy Medical sciences Pharmacology. Drug treatments Recombinant Proteins - pharmacology RNA, Messenger - analysis RNA, Neoplasm - analysis Tumor Cells, Cultured
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