Induction of micronuclei, DNA strand breaks and HPRT mutations in cultured Chinese hamster V79 cells by the phytoestrogen coumoestrol

Coumoestrol (COUM), genistein (GEN) and daidzein (DAI) are major phytoestrogens present in numerous plants eaten by humans and food-producing animals. Little is known about the genotoxicity of these natural compounds. The effects of COUM, GEN and DAI were studied in cultured Chinese hamster V79 cell...

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Veröffentlicht in:	Food and chemical toxicology 1997-06, Vol.35 (6), p.605-613
Hauptverfasser:	Kulling, S.E., Metzler, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Survival - drug effects Cells, Cultured - drug effects Coumestrol - chemistry Coumestrol - toxicity Cricetinae Cricetulus DNA Damage - drug effects Estrogens, Non-Steroidal - chemistry Estrogens, Non-Steroidal - toxicity Fibroblasts - drug effects Fibroblasts - enzymology Fibroblasts - pathology Food toxicology Genistein Hypoxanthine Phosphoribosyltransferase - drug effects Hypoxanthine Phosphoribosyltransferase - genetics Isoflavones - chemistry Isoflavones - toxicity Lung - drug effects Lung - enzymology Lung - pathology Medical sciences Micronuclei, Chromosome-Defective - drug effects Mutagenicity Tests Mutation Toxicology
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