Nitrite-induced adrenal effects in rats and the consequences for the no-observed-effect level

In a previous subchronic oral toxicity study with potassium nitrite, hypertrophy of the adrenal zona glomerulosa was observed for all nitrite levels examined including the lowest level of 100 mg/litre. This present study was carried out, therefore, to establish a no-observed-effect level (NOEL) for...

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Veröffentlicht in:	Food and chemical toxicology 1997-03, Vol.35 (3), p.349-355
Hauptverfasser:	Til, H.P., Kuper, C.F., Falke, H.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Body Weight - drug effects Eating - drug effects Female Food Preservatives - toxicity Food toxicology Hypertrophy - pathology Kidney - drug effects Kidney - pathology Male Medical sciences Nitrites - toxicity No-Observed-Adverse-Effect Level Rats Rats, Wistar Sodium Nitrite - toxicity Toxicology Zona Glomerulosa - drug effects Zona Glomerulosa - pathology
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