Intracranial administration of adenovirus expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response

Replication-defective adenovirus expressing the herpes simplex thymidine kinase gene (H5.010RSVtk) may be useful in treating human gliomas. To determine the toxicity of this therapeutic strategy, we injected H5.010RSVtk stereotactically into the normal brain of Wistar rats, cotton rats, and rhesus m...

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Veröffentlicht in:	Human gene therapy 1997-05, Vol.8 (8), p.943-954
Hauptverfasser:	Smith, J G, Raper, S E, Wheeldon, E B, Hackney, D, Judy, K, Wilson, J M, Eck, S L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics adenovirus Animals Antiviral Agents - therapeutic use Brain - virology Dose-Response Relationship, Drug Drug Evaluation, Preclinical Ganciclovir - therapeutic use Genetic Vectors herpes simplex virus Inflammation - virology Macaca mulatta Male Rats Rats, Wistar Sigmodontinae Simplexvirus - genetics Stereotaxic Techniques Thymidine Kinase - genetics
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