Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKC γ

In normal animals, peripheral nerve injury produces a persistent, neuropathic pain state in which pain is exaggerated and can be produced by nonpainful stimuli. Here, mice that lack protein kinase C gamma (PKCγ) displayed normal responses to acute pain stimuli, but they almost completely failed to d...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1997-10, Vol.278 (5336), p.279-283
Hauptverfasser:	Malmberg, Annika B., Chen, Chong, Tonegawa, Susumu, Basbaum, Allan I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Injuries Medical sciences Mice Nerves Nerves, Peripheral Nervous system (semeiology, syndromes) Nervous system trauma Neurology Neurons Pain Peripheral nerve diseases Peripheral nerves Peripheral nervous system diseases Physical trauma Physiological aspects Receptors Sciatic nerve Spinal cord
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