Influence of BDNF Val66Met on the relationship between physical activity and brain volume
OBJECTIVE:To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. METHODS:This study is a cross-sectional analysis of 114 cognitively healthy men and women a...
Gespeichert in:
| Veröffentlicht in: | Neurology 2014-10, Vol.83 (15), p.1345-1352 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1352 |
|---|---|
| container_issue | 15 |
| container_start_page | 1345 |
| container_title | Neurology |
| container_volume | 83 |
| creator | Brown, Belinda M Bourgeat, Pierrick Peiffer, Jeremiah J Burnham, Samantha Laws, Simon M Rainey-Smith, Stephanie R Bartrés-Faz, David Villemagne, Victor L Taddei, Kevin Rembach, Alan Bush, Ashley Ellis, Kathryn A Macaulay, S Lance Rowe, Christopher C Ames, David Masters, Colin L Maruff, Paul Martins, Ralph N |
| description | OBJECTIVE:To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.
METHODS:This study is a cross-sectional analysis of 114 cognitively healthy men and women aged 60 years and older. Brain volumes quantified by MRI were correlated with self-reported physical activity levels. The effect of the interaction between physical activity and the BDNF Val66Met polymorphism on brain structure volumes was assessed. Post hoc analyses were completed to evaluate the influence of the APOE ε4 allele on any found associations.
RESULTS:The BDNF Val66Met polymorphism interacted with physical activity to be associated with hippocampal (β = −0.22, p = 0.02) and temporal lobe (β = −0.28, p = 0.003) volumes. In Val/Val homozygotes, higher levels of physical activity were associated with larger hippocampal and temporal lobe volumes, whereas in Met carriers, higher levels of physical activity were associated with smaller temporal lobe volume.
CONCLUSION:The findings from this study support higher physical activity levels in the potential attenuation of age- and disease-related hippocampal and temporal lobe volume loss in Val/Val homozygotes. |
| doi_str_mv | 10.1212/WNL.0000000000000867 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1609309079</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1609309079</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3567-11b9f57da430f6e1fba9c9c0b5aa3eb4f43e7ddcd48553bbb1ddee2329cc01d93</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EoqXwBwh5ySbFjhMnWUKhUKmUDc9V5MdECbhJsZ1W_XtStSDEgtnMYs69Ix2ETikZ0pCGFy-z6ZD8npQne6hP45AHnIWv-6hPSJgGLE3SHjpy7p2Q7phkh6gXxjTlKWd99DapC9NCrQA3Bb66no3xszCc34PHTY19CdiCEb5qaldWCyzBrwBqvCjXrlLCYKF8taz8GotaY2lFVeNlY9o5HKODQhgHJ7s9QE_jm8fRXTB9uJ2MLqeBYjFPAkplVsSJFhEjBQdaSJGpTBEZC8FARkXEINFa6SiNYyalpFoDhCzMlCJUZ2yAzre9C9t8tuB8Pq-cAmNEDU3rcspJxkhGkg0abVFlG-csFPnCVnNh1zkl-UZq3knN_0rtYme7D62cg_4JfVvsgHQLrBrjwboP067A5iUI48v_u78ArhSEMQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1609309079</pqid></control><display><type>article</type><title>Influence of BDNF Val66Met on the relationship between physical activity and brain volume</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>Brown, Belinda M ; Bourgeat, Pierrick ; Peiffer, Jeremiah J ; Burnham, Samantha ; Laws, Simon M ; Rainey-Smith, Stephanie R ; Bartrés-Faz, David ; Villemagne, Victor L ; Taddei, Kevin ; Rembach, Alan ; Bush, Ashley ; Ellis, Kathryn A ; Macaulay, S Lance ; Rowe, Christopher C ; Ames, David ; Masters, Colin L ; Maruff, Paul ; Martins, Ralph N</creator><creatorcontrib>Brown, Belinda M ; Bourgeat, Pierrick ; Peiffer, Jeremiah J ; Burnham, Samantha ; Laws, Simon M ; Rainey-Smith, Stephanie R ; Bartrés-Faz, David ; Villemagne, Victor L ; Taddei, Kevin ; Rembach, Alan ; Bush, Ashley ; Ellis, Kathryn A ; Macaulay, S Lance ; Rowe, Christopher C ; Ames, David ; Masters, Colin L ; Maruff, Paul ; Martins, Ralph N ; AIBL Research Group ; For the AIBL Research Group</creatorcontrib><description>OBJECTIVE:To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.
METHODS:This study is a cross-sectional analysis of 114 cognitively healthy men and women aged 60 years and older. Brain volumes quantified by MRI were correlated with self-reported physical activity levels. The effect of the interaction between physical activity and the BDNF Val66Met polymorphism on brain structure volumes was assessed. Post hoc analyses were completed to evaluate the influence of the APOE ε4 allele on any found associations.
RESULTS:The BDNF Val66Met polymorphism interacted with physical activity to be associated with hippocampal (β = −0.22, p = 0.02) and temporal lobe (β = −0.28, p = 0.003) volumes. In Val/Val homozygotes, higher levels of physical activity were associated with larger hippocampal and temporal lobe volumes, whereas in Met carriers, higher levels of physical activity were associated with smaller temporal lobe volume.
CONCLUSION:The findings from this study support higher physical activity levels in the potential attenuation of age- and disease-related hippocampal and temporal lobe volume loss in Val/Val homozygotes.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.0000000000000867</identifier><identifier>PMID: 25186863</identifier><language>eng</language><publisher>United States: American Academy of Neurology</publisher><subject>Aged ; Apolipoprotein E2 - genetics ; Brain-Derived Neurotrophic Factor - genetics ; Cross-Sectional Studies ; Female ; Hippocampus - anatomy & histology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Activity - genetics ; Neuroimaging ; Polymorphism, Single Nucleotide - genetics ; Temporal Lobe - anatomy & histology</subject><ispartof>Neurology, 2014-10, Vol.83 (15), p.1345-1352</ispartof><rights>2014 American Academy of Neurology</rights><rights>2014 American Academy of Neurology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3567-11b9f57da430f6e1fba9c9c0b5aa3eb4f43e7ddcd48553bbb1ddee2329cc01d93</citedby><cites>FETCH-LOGICAL-c3567-11b9f57da430f6e1fba9c9c0b5aa3eb4f43e7ddcd48553bbb1ddee2329cc01d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25186863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, Belinda M</creatorcontrib><creatorcontrib>Bourgeat, Pierrick</creatorcontrib><creatorcontrib>Peiffer, Jeremiah J</creatorcontrib><creatorcontrib>Burnham, Samantha</creatorcontrib><creatorcontrib>Laws, Simon M</creatorcontrib><creatorcontrib>Rainey-Smith, Stephanie R</creatorcontrib><creatorcontrib>Bartrés-Faz, David</creatorcontrib><creatorcontrib>Villemagne, Victor L</creatorcontrib><creatorcontrib>Taddei, Kevin</creatorcontrib><creatorcontrib>Rembach, Alan</creatorcontrib><creatorcontrib>Bush, Ashley</creatorcontrib><creatorcontrib>Ellis, Kathryn A</creatorcontrib><creatorcontrib>Macaulay, S Lance</creatorcontrib><creatorcontrib>Rowe, Christopher C</creatorcontrib><creatorcontrib>Ames, David</creatorcontrib><creatorcontrib>Masters, Colin L</creatorcontrib><creatorcontrib>Maruff, Paul</creatorcontrib><creatorcontrib>Martins, Ralph N</creatorcontrib><creatorcontrib>AIBL Research Group</creatorcontrib><creatorcontrib>For the AIBL Research Group</creatorcontrib><title>Influence of BDNF Val66Met on the relationship between physical activity and brain volume</title><title>Neurology</title><addtitle>Neurology</addtitle><description>OBJECTIVE:To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.
METHODS:This study is a cross-sectional analysis of 114 cognitively healthy men and women aged 60 years and older. Brain volumes quantified by MRI were correlated with self-reported physical activity levels. The effect of the interaction between physical activity and the BDNF Val66Met polymorphism on brain structure volumes was assessed. Post hoc analyses were completed to evaluate the influence of the APOE ε4 allele on any found associations.
RESULTS:The BDNF Val66Met polymorphism interacted with physical activity to be associated with hippocampal (β = −0.22, p = 0.02) and temporal lobe (β = −0.28, p = 0.003) volumes. In Val/Val homozygotes, higher levels of physical activity were associated with larger hippocampal and temporal lobe volumes, whereas in Met carriers, higher levels of physical activity were associated with smaller temporal lobe volume.
CONCLUSION:The findings from this study support higher physical activity levels in the potential attenuation of age- and disease-related hippocampal and temporal lobe volume loss in Val/Val homozygotes.</description><subject>Aged</subject><subject>Apolipoprotein E2 - genetics</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Hippocampus - anatomy & histology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Activity - genetics</subject><subject>Neuroimaging</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Temporal Lobe - anatomy & histology</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwBwh5ySbFjhMnWUKhUKmUDc9V5MdECbhJsZ1W_XtStSDEgtnMYs69Ix2ETikZ0pCGFy-z6ZD8npQne6hP45AHnIWv-6hPSJgGLE3SHjpy7p2Q7phkh6gXxjTlKWd99DapC9NCrQA3Bb66no3xszCc34PHTY19CdiCEb5qaldWCyzBrwBqvCjXrlLCYKF8taz8GotaY2lFVeNlY9o5HKODQhgHJ7s9QE_jm8fRXTB9uJ2MLqeBYjFPAkplVsSJFhEjBQdaSJGpTBEZC8FARkXEINFa6SiNYyalpFoDhCzMlCJUZ2yAzre9C9t8tuB8Pq-cAmNEDU3rcspJxkhGkg0abVFlG-csFPnCVnNh1zkl-UZq3knN_0rtYme7D62cg_4JfVvsgHQLrBrjwboP067A5iUI48v_u78ArhSEMQ</recordid><startdate>20141007</startdate><enddate>20141007</enddate><creator>Brown, Belinda M</creator><creator>Bourgeat, Pierrick</creator><creator>Peiffer, Jeremiah J</creator><creator>Burnham, Samantha</creator><creator>Laws, Simon M</creator><creator>Rainey-Smith, Stephanie R</creator><creator>Bartrés-Faz, David</creator><creator>Villemagne, Victor L</creator><creator>Taddei, Kevin</creator><creator>Rembach, Alan</creator><creator>Bush, Ashley</creator><creator>Ellis, Kathryn A</creator><creator>Macaulay, S Lance</creator><creator>Rowe, Christopher C</creator><creator>Ames, David</creator><creator>Masters, Colin L</creator><creator>Maruff, Paul</creator><creator>Martins, Ralph N</creator><general>American Academy of Neurology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141007</creationdate><title>Influence of BDNF Val66Met on the relationship between physical activity and brain volume</title><author>Brown, Belinda M ; Bourgeat, Pierrick ; Peiffer, Jeremiah J ; Burnham, Samantha ; Laws, Simon M ; Rainey-Smith, Stephanie R ; Bartrés-Faz, David ; Villemagne, Victor L ; Taddei, Kevin ; Rembach, Alan ; Bush, Ashley ; Ellis, Kathryn A ; Macaulay, S Lance ; Rowe, Christopher C ; Ames, David ; Masters, Colin L ; Maruff, Paul ; Martins, Ralph N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3567-11b9f57da430f6e1fba9c9c0b5aa3eb4f43e7ddcd48553bbb1ddee2329cc01d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Apolipoprotein E2 - genetics</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Hippocampus - anatomy & histology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor Activity - genetics</topic><topic>Neuroimaging</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Temporal Lobe - anatomy & histology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, Belinda M</creatorcontrib><creatorcontrib>Bourgeat, Pierrick</creatorcontrib><creatorcontrib>Peiffer, Jeremiah J</creatorcontrib><creatorcontrib>Burnham, Samantha</creatorcontrib><creatorcontrib>Laws, Simon M</creatorcontrib><creatorcontrib>Rainey-Smith, Stephanie R</creatorcontrib><creatorcontrib>Bartrés-Faz, David</creatorcontrib><creatorcontrib>Villemagne, Victor L</creatorcontrib><creatorcontrib>Taddei, Kevin</creatorcontrib><creatorcontrib>Rembach, Alan</creatorcontrib><creatorcontrib>Bush, Ashley</creatorcontrib><creatorcontrib>Ellis, Kathryn A</creatorcontrib><creatorcontrib>Macaulay, S Lance</creatorcontrib><creatorcontrib>Rowe, Christopher C</creatorcontrib><creatorcontrib>Ames, David</creatorcontrib><creatorcontrib>Masters, Colin L</creatorcontrib><creatorcontrib>Maruff, Paul</creatorcontrib><creatorcontrib>Martins, Ralph N</creatorcontrib><creatorcontrib>AIBL Research Group</creatorcontrib><creatorcontrib>For the AIBL Research Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brown, Belinda M</au><au>Bourgeat, Pierrick</au><au>Peiffer, Jeremiah J</au><au>Burnham, Samantha</au><au>Laws, Simon M</au><au>Rainey-Smith, Stephanie R</au><au>Bartrés-Faz, David</au><au>Villemagne, Victor L</au><au>Taddei, Kevin</au><au>Rembach, Alan</au><au>Bush, Ashley</au><au>Ellis, Kathryn A</au><au>Macaulay, S Lance</au><au>Rowe, Christopher C</au><au>Ames, David</au><au>Masters, Colin L</au><au>Maruff, Paul</au><au>Martins, Ralph N</au><aucorp>AIBL Research Group</aucorp><aucorp>For the AIBL Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of BDNF Val66Met on the relationship between physical activity and brain volume</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2014-10-07</date><risdate>2014</risdate><volume>83</volume><issue>15</issue><spage>1345</spage><epage>1352</epage><pages>1345-1352</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><abstract>OBJECTIVE:To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.
METHODS:This study is a cross-sectional analysis of 114 cognitively healthy men and women aged 60 years and older. Brain volumes quantified by MRI were correlated with self-reported physical activity levels. The effect of the interaction between physical activity and the BDNF Val66Met polymorphism on brain structure volumes was assessed. Post hoc analyses were completed to evaluate the influence of the APOE ε4 allele on any found associations.
RESULTS:The BDNF Val66Met polymorphism interacted with physical activity to be associated with hippocampal (β = −0.22, p = 0.02) and temporal lobe (β = −0.28, p = 0.003) volumes. In Val/Val homozygotes, higher levels of physical activity were associated with larger hippocampal and temporal lobe volumes, whereas in Met carriers, higher levels of physical activity were associated with smaller temporal lobe volume.
CONCLUSION:The findings from this study support higher physical activity levels in the potential attenuation of age- and disease-related hippocampal and temporal lobe volume loss in Val/Val homozygotes.</abstract><cop>United States</cop><pub>American Academy of Neurology</pub><pmid>25186863</pmid><doi>10.1212/WNL.0000000000000867</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-3878 |
| ispartof | Neurology, 2014-10, Vol.83 (15), p.1345-1352 |
| issn | 0028-3878 1526-632X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1609309079 |
| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Apolipoprotein E2 - genetics Brain-Derived Neurotrophic Factor - genetics Cross-Sectional Studies Female Hippocampus - anatomy & histology Humans Magnetic Resonance Imaging Male Middle Aged Motor Activity - genetics Neuroimaging Polymorphism, Single Nucleotide - genetics Temporal Lobe - anatomy & histology |
| title | Influence of BDNF Val66Met on the relationship between physical activity and brain volume |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T22%3A53%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20BDNF%20Val66Met%20on%20the%20relationship%20between%20physical%20activity%20and%20brain%20volume&rft.jtitle=Neurology&rft.au=Brown,%20Belinda%20M&rft.aucorp=AIBL%20Research%20Group&rft.date=2014-10-07&rft.volume=83&rft.issue=15&rft.spage=1345&rft.epage=1352&rft.pages=1345-1352&rft.issn=0028-3878&rft.eissn=1526-632X&rft_id=info:doi/10.1212/WNL.0000000000000867&rft_dat=%3Cproquest_cross%3E1609309079%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1609309079&rft_id=info:pmid/25186863&rfr_iscdi=true |