The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles

The rhomboid proteases were first discovered as regulators of Drosophila EGF receptor signaling; soon after, it was recognized that they represented the founder members of a widespread family of intramembrane serine proteases conserved in all kingdoms. More recently still, the family was promoted to...

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Veröffentlicht in:	Annual review of cell and developmental biology 2014-01, Vol.30 (1), p.235-254
1. Verfasser:	Freeman, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - physiology Catalytic Domain disease Drosophila Proteins - physiology enzyme Humans Inflammation - enzymology iRhom Mammals - metabolism membrane protein Membrane Proteins - classification Membrane Proteins - physiology mitochondria Mitochondria - enzymology Mitochondrial Proteins - physiology Multigene Family Parasitic Diseases - enzymology Plant Proteins - physiology protease Proteolysis rhomboid Serine Proteases - classification Serine Proteases - physiology signaling Terminology as Topic
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