Rethinking Composite End Points in Clinical Trials: Insights From Patients and Trialists

BACKGROUND—Many clinical trials use composite end points to reduce sample size, but the relative importance of each individual end point within the composite may differ between patients and researchers. METHODS AND RESULTS—We asked 785 cardiovascular patients and 164 clinical trial authors to assign...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2014-10, Vol.130 (15), p.1254-1261
Hauptverfasser:	Stolker, Joshua M, Spertus, John A, Cohen, David J, Jones, Philip G, Jain, Kaushik K, Bamberger, Emily, Lonergan, Brady B, Chan, Paul S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Angina, Unstable - mortality Angina, Unstable - prevention & control Clinical Trials as Topic - psychology Data Collection Endpoint Determination - psychology Female Health Personnel - psychology Hospitalization Humans Male Myocardial Infarction - mortality Myocardial Infarction - prevention & control Patient Preference Patient-Centered Care Patients - psychology Percutaneous Coronary Intervention Risk Factors Stroke - mortality Stroke - prevention & control
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