Efficacy of polyunsaturated fatty acids for dry eye syndrome: a meta‐analysis of randomized controlled trials
Dry eye syndrome (DES) is a common ocular disease that significantly affects the quality of life. Polyunsaturated fatty acids (PUFAs) have been used to treat DES; however, randomized controlled trials (RCTs) of PUFA therapy yield discordant results. The objective of this study was to clarify the eff...
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| Veröffentlicht in: | Nutrition reviews 2014-10, Vol.72 (10), p.662-671 |
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| description | Dry eye syndrome (DES) is a common ocular disease that significantly affects the quality of life. Polyunsaturated fatty acids (PUFAs) have been used to treat DES; however, randomized controlled trials (RCTs) of PUFA therapy yield discordant results. The objective of this study was to clarify the effects of PUFAs on DES through meta‐analysis of all relevant RCTs. To do so, a comprehensive search of PubMed, Embase, the Cochrane Library, ISI Web of Science, and unpublished data was conducted. The changes in clinical and laboratory examinations, symptomatic scores, and rates of relevant symptoms were analyzed. Nine RCTs were included in the current meta‐analysis. Compared with placebo, PUFA supplementation was not related to changes in tear film break‐up time (weighted mean difference [WMD], 0.33; 95% confidence interval [CI], −0.05 to 0.72), Schirmer's test score (WMD, 0.32; 95%CI, −0.23 to 0.86), or lissamine green staining score (WMD, −0.77; 95%CI, −1.66 to 0.12). However, significant reductions were detected in the symptom score on the ocular surface disease index (WMD, −2.26; 95%CI, −4.44 to −0.08) and in the rate of cells positive for human leukocyte antigen DR (WMD, −5.80; 95%CI, −8.62 to −2.97). This comprehensive meta‐analysis supports the use of PUFA supplementation as a potential effective therapy for DES. |
| doi_str_mv | 10.1111/nure.12145 |
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Polyunsaturated fatty acids (PUFAs) have been used to treat DES; however, randomized controlled trials (RCTs) of PUFA therapy yield discordant results. The objective of this study was to clarify the effects of PUFAs on DES through meta‐analysis of all relevant RCTs. To do so, a comprehensive search of PubMed, Embase, the Cochrane Library, ISI Web of Science, and unpublished data was conducted. The changes in clinical and laboratory examinations, symptomatic scores, and rates of relevant symptoms were analyzed. Nine RCTs were included in the current meta‐analysis. Compared with placebo, PUFA supplementation was not related to changes in tear film break‐up time (weighted mean difference [WMD], 0.33; 95% confidence interval [CI], −0.05 to 0.72), Schirmer's test score (WMD, 0.32; 95%CI, −0.23 to 0.86), or lissamine green staining score (WMD, −0.77; 95%CI, −1.66 to 0.12). However, significant reductions were detected in the symptom score on the ocular surface disease index (WMD, −2.26; 95%CI, −4.44 to −0.08) and in the rate of cells positive for human leukocyte antigen DR (WMD, −5.80; 95%CI, −8.62 to −2.97). This comprehensive meta‐analysis supports the use of PUFA supplementation as a potential effective therapy for DES.</description><identifier>ISSN: 0029-6643</identifier><identifier>EISSN: 1753-4887</identifier><identifier>DOI: 10.1111/nure.12145</identifier><identifier>PMID: 25236365</identifier><identifier>CODEN: NUREA8</identifier><language>eng</language><publisher>Hoboken, NJ: International Life Sciences Institute</publisher><subject>Animals ; Antigens ; Biological and medical sciences ; confidence interval ; Dietary Supplements ; dry eye syndrome ; Dry Eye Syndromes - diet therapy ; eye irritation ; eyes ; Fatty acids ; Fatty Acids, Unsaturated - administration & dosage ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Humans ; Leukocytes ; Meta-analysis ; polyunsaturated fatty acids ; Quality of Life ; randomized clinical trials ; Randomized Controlled Trials as Topic ; therapeutics ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Nutrition reviews, 2014-10, Vol.72 (10), p.662-671</ispartof><rights>2014 International Life Sciences Institute</rights><rights>2015 INIST-CNRS</rights><rights>2014 International Life Sciences Institute.</rights><rights>Copyright International Life Sciences Institute Oct 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4815-5220d446bb3bf9bbda818c78f57eaab7e92437c16bde56ca90378f70c6b6f4213</citedby><cites>FETCH-LOGICAL-c4815-5220d446bb3bf9bbda818c78f57eaab7e92437c16bde56ca90378f70c6b6f4213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnure.12145$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnure.12145$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28945728$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25236365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Wei</creatorcontrib><creatorcontrib>Wu, Yan</creatorcontrib><creatorcontrib>Li, Guigang</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Li, Xinyu</creatorcontrib><title>Efficacy of polyunsaturated fatty acids for dry eye syndrome: a meta‐analysis of randomized controlled trials</title><title>Nutrition reviews</title><addtitle>Nutr Rev</addtitle><description>Dry eye syndrome (DES) is a common ocular disease that significantly affects the quality of life. Polyunsaturated fatty acids (PUFAs) have been used to treat DES; however, randomized controlled trials (RCTs) of PUFA therapy yield discordant results. The objective of this study was to clarify the effects of PUFAs on DES through meta‐analysis of all relevant RCTs. To do so, a comprehensive search of PubMed, Embase, the Cochrane Library, ISI Web of Science, and unpublished data was conducted. The changes in clinical and laboratory examinations, symptomatic scores, and rates of relevant symptoms were analyzed. Nine RCTs were included in the current meta‐analysis. Compared with placebo, PUFA supplementation was not related to changes in tear film break‐up time (weighted mean difference [WMD], 0.33; 95% confidence interval [CI], −0.05 to 0.72), Schirmer's test score (WMD, 0.32; 95%CI, −0.23 to 0.86), or lissamine green staining score (WMD, −0.77; 95%CI, −1.66 to 0.12). However, significant reductions were detected in the symptom score on the ocular surface disease index (WMD, −2.26; 95%CI, −4.44 to −0.08) and in the rate of cells positive for human leukocyte antigen DR (WMD, −5.80; 95%CI, −8.62 to −2.97). This comprehensive meta‐analysis supports the use of PUFA supplementation as a potential effective therapy for DES.</description><subject>Animals</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>confidence interval</subject><subject>Dietary Supplements</subject><subject>dry eye syndrome</subject><subject>Dry Eye Syndromes - diet therapy</subject><subject>eye irritation</subject><subject>eyes</subject><subject>Fatty acids</subject><subject>Fatty Acids, Unsaturated - administration & dosage</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Leukocytes</subject><subject>Meta-analysis</subject><subject>polyunsaturated fatty acids</subject><subject>Quality of Life</subject><subject>randomized clinical trials</subject><subject>Randomized Controlled Trials as Topic</subject><subject>therapeutics</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0029-6643</issn><issn>1753-4887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd9qFDEUh4NY7LZ64wNoQAoiTM3_ZHonZdVCUVD3ejiTSWTKzGRNZpB45SP4jD5Js-7WgheGwAnky3fI-SH0lJJzWtbraYnunDIq5AO0olryShijH6IVIayulBL8GJ2kdEMIoazmj9Axk4wrruQKhbX3vQWbcfB4G4a8TAnmJcLsOuxhnjMG23cJ-xBxFzN22eGUpy6G0V1gwKOb4ffPXzDBkFOfdpoIUxfG_kcx2DDNMQxDOc6xhyE9Rke-FPfkUE_R5u36y-X76vrju6vLN9eVFYbKSjJGOiFU2_LW123bgaHGauOldgCtdjUTXFuq2s5JZaEmvFxqYlWrvGCUn6KXe-82hm-LS3Mz9sm6YYDJhSU1VJGaE8WoLuiLf9CbsMTynx1FpVbaCF6oV3vKxpBSdL7Zxn6EmBtKml0MzS6G5k8MBX52UC7t6Lq_6N3cC3B2ACBZGHwZme3TPWdqITUzhaN77ns_uPyfls2Hzaf1XfPn-zceQgNfY_FuPjNCZcnflE35LT8fqo0</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Zhu, Wei</creator><creator>Wu, Yan</creator><creator>Li, Guigang</creator><creator>Wang, Juan</creator><creator>Li, Xinyu</creator><general>International Life Sciences Institute</general><general>Wiley</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>Efficacy of polyunsaturated fatty acids for dry eye syndrome: a meta‐analysis of randomized controlled trials</title><author>Zhu, Wei ; Wu, Yan ; Li, Guigang ; Wang, Juan ; Li, Xinyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4815-5220d446bb3bf9bbda818c78f57eaab7e92437c16bde56ca90378f70c6b6f4213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>confidence interval</topic><topic>Dietary Supplements</topic><topic>dry eye syndrome</topic><topic>Dry Eye Syndromes - diet therapy</topic><topic>eye irritation</topic><topic>eyes</topic><topic>Fatty acids</topic><topic>Fatty Acids, Unsaturated - administration & dosage</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Leukocytes</topic><topic>Meta-analysis</topic><topic>polyunsaturated fatty acids</topic><topic>Quality of Life</topic><topic>randomized clinical trials</topic><topic>Randomized Controlled Trials as Topic</topic><topic>therapeutics</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Wei</creatorcontrib><creatorcontrib>Wu, Yan</creatorcontrib><creatorcontrib>Li, Guigang</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Li, Xinyu</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Wei</au><au>Wu, Yan</au><au>Li, Guigang</au><au>Wang, Juan</au><au>Li, Xinyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of polyunsaturated fatty acids for dry eye syndrome: a meta‐analysis of randomized controlled trials</atitle><jtitle>Nutrition reviews</jtitle><addtitle>Nutr Rev</addtitle><date>2014-10</date><risdate>2014</risdate><volume>72</volume><issue>10</issue><spage>662</spage><epage>671</epage><pages>662-671</pages><issn>0029-6643</issn><eissn>1753-4887</eissn><coden>NUREA8</coden><abstract>Dry eye syndrome (DES) is a common ocular disease that significantly affects the quality of life. Polyunsaturated fatty acids (PUFAs) have been used to treat DES; however, randomized controlled trials (RCTs) of PUFA therapy yield discordant results. The objective of this study was to clarify the effects of PUFAs on DES through meta‐analysis of all relevant RCTs. To do so, a comprehensive search of PubMed, Embase, the Cochrane Library, ISI Web of Science, and unpublished data was conducted. The changes in clinical and laboratory examinations, symptomatic scores, and rates of relevant symptoms were analyzed. Nine RCTs were included in the current meta‐analysis. Compared with placebo, PUFA supplementation was not related to changes in tear film break‐up time (weighted mean difference [WMD], 0.33; 95% confidence interval [CI], −0.05 to 0.72), Schirmer's test score (WMD, 0.32; 95%CI, −0.23 to 0.86), or lissamine green staining score (WMD, −0.77; 95%CI, −1.66 to 0.12). However, significant reductions were detected in the symptom score on the ocular surface disease index (WMD, −2.26; 95%CI, −4.44 to −0.08) and in the rate of cells positive for human leukocyte antigen DR (WMD, −5.80; 95%CI, −8.62 to −2.97). This comprehensive meta‐analysis supports the use of PUFA supplementation as a potential effective therapy for DES.</abstract><cop>Hoboken, NJ</cop><pub>International Life Sciences Institute</pub><pmid>25236365</pmid><doi>10.1111/nure.12145</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Antigens Biological and medical sciences confidence interval Dietary Supplements dry eye syndrome Dry Eye Syndromes - diet therapy eye irritation eyes Fatty acids Fatty Acids, Unsaturated - administration & dosage Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Humans Leukocytes Meta-analysis polyunsaturated fatty acids Quality of Life randomized clinical trials Randomized Controlled Trials as Topic therapeutics Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Efficacy of polyunsaturated fatty acids for dry eye syndrome: a meta‐analysis of randomized controlled trials |
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