Increase of auto anti-phosphatidylinositol antibodies in plasma of female rats during the appearance of DMBA-induced malignant mammary tumors
Using a lipid-adapted ELISA, antiphosphatidylinositol (PtdIns) antibodies (Ab) have been found in sera of cancer patients. With the same procedure, we have checked their possible raising in plasma of female rats during the appearance of 7,12-dimethylbenz[ a]anthracene (DMBA)-induced mammary tumors....
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| Veröffentlicht in: | Cancer letters 1991-04, Vol.57 (1), p.15-19 |
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| container_title | Cancer letters |
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| creator | Faiderbe, S. Chagnaud, J.-L. Diolez-Bojda, F. Kerdélhué, B. Geffard, M. |
| description | Using a lipid-adapted ELISA, antiphosphatidylinositol (PtdIns) antibodies (Ab) have been found in sera of cancer patients. With the same procedure, we have checked their possible raising in plasma of female rats during the appearance of 7,12-dimethylbenz[
a]anthracene (DMBA)-induced mammary tumors. Twenty days after DMBA administration, the mean anti-PtdIns Ab level was already higher than that of control rats (oil). Immunochemical analysis of the anti-PtdIns Ab site showed a rather high Ab avidity (8 × 10
−9 M, at half-displacement) and high specificity for glyceryl phosphate inositol residues. Other phospholipids (PL) were not recognized by the anti-PtdIns Ab induced by malignant cell transformation. |
| doi_str_mv | 10.1016/0304-3835(91)90057-O |
| format | Article |
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a]anthracene (DMBA)-induced mammary tumors. Twenty days after DMBA administration, the mean anti-PtdIns Ab level was already higher than that of control rats (oil). Immunochemical analysis of the anti-PtdIns Ab site showed a rather high Ab avidity (8 × 10
−9 M, at half-displacement) and high specificity for glyceryl phosphate inositol residues. Other phospholipids (PL) were not recognized by the anti-PtdIns Ab induced by malignant cell transformation.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(91)90057-O</identifier><identifier>PMID: 1902757</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>9,10-Dimethyl-1,2-benzanthracene ; Animal tumors. Experimental tumors ; Animals ; Antibody Affinity ; Antibody Specificity ; Autoantibodies - analysis ; autoantibody ; avidity ; Biological and medical sciences ; DMBA ; Enzyme-Linked Immunosorbent Assay ; Experimental genital and mammary tumors ; Female ; Mammary Neoplasms, Experimental - chemically induced ; Mammary Neoplasms, Experimental - immunology ; mammary tumor ; Medical sciences ; phosphatidylinositol ; Phosphatidylinositols - immunology ; Rats ; Rats, Inbred Strains ; Reference Values ; specificity ; Time Factors ; Tumors</subject><ispartof>Cancer letters, 1991-04, Vol.57 (1), p.15-19</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-1e545cd6d74905c1c1919a6f228977a1512a3f53b51f94c0255da53025a23b193</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/030438359190057O$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19663126$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1902757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faiderbe, S.</creatorcontrib><creatorcontrib>Chagnaud, J.-L.</creatorcontrib><creatorcontrib>Diolez-Bojda, F.</creatorcontrib><creatorcontrib>Kerdélhué, B.</creatorcontrib><creatorcontrib>Geffard, M.</creatorcontrib><title>Increase of auto anti-phosphatidylinositol antibodies in plasma of female rats during the appearance of DMBA-induced malignant mammary tumors</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Using a lipid-adapted ELISA, antiphosphatidylinositol (PtdIns) antibodies (Ab) have been found in sera of cancer patients. With the same procedure, we have checked their possible raising in plasma of female rats during the appearance of 7,12-dimethylbenz[
a]anthracene (DMBA)-induced mammary tumors. Twenty days after DMBA administration, the mean anti-PtdIns Ab level was already higher than that of control rats (oil). Immunochemical analysis of the anti-PtdIns Ab site showed a rather high Ab avidity (8 × 10
−9 M, at half-displacement) and high specificity for glyceryl phosphate inositol residues. Other phospholipids (PL) were not recognized by the anti-PtdIns Ab induced by malignant cell transformation.</description><subject>9,10-Dimethyl-1,2-benzanthracene</subject><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Antibody Affinity</subject><subject>Antibody Specificity</subject><subject>Autoantibodies - analysis</subject><subject>autoantibody</subject><subject>avidity</subject><subject>Biological and medical sciences</subject><subject>DMBA</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Experimental genital and mammary tumors</subject><subject>Female</subject><subject>Mammary Neoplasms, Experimental - chemically induced</subject><subject>Mammary Neoplasms, Experimental - immunology</subject><subject>mammary tumor</subject><subject>Medical sciences</subject><subject>phosphatidylinositol</subject><subject>Phosphatidylinositols - immunology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reference Values</subject><subject>specificity</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS0EKtvCNwDJF1A5BDxJnMQXpFL-VSraC5ytWXvSNUriYDtI_RB8Z5zdFXDiNCO933savWHsGYjXIKB5IypRF1VXyUsFr5QQsi22D9gGurYsWtWJh2zzB3nMzmP8LjJUt_KMnYESZSvbDft1M5lAGIn7nuOSPMcpuWLe-zjvMTl7P7jJR5f8cFB23jqK3E18HjCOuNp6GnEgHjBFbpfgpjue9sRxngkDTuaQ_f7Lu6vCTXYxZHnm3d2U8_I2jhjueVpGH-IT9qjHIdLT07xg3z5--Hr9ubjdfrq5vrotTA1dKoBkLY1tbFsrIQ0YUKCw6cuyU22LIKHEqpfVTkKvaiNKKS3KKk8sqx2o6oK9PObOwf9YKCY9umhoGHAiv0QNjVClbEQG6yNogo8xUK_n4NaDNQi9fkGvFeu1Yq1AH76gt9n2_JS_7Eayf03H2rP-4qRjNDj0a0su_oM1TQVlk7m3R45yGT8dBR2No9yodYFM0ta7_x_yG3yXpPQ</recordid><startdate>19910401</startdate><enddate>19910401</enddate><creator>Faiderbe, S.</creator><creator>Chagnaud, J.-L.</creator><creator>Diolez-Bojda, F.</creator><creator>Kerdélhué, B.</creator><creator>Geffard, M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19910401</creationdate><title>Increase of auto anti-phosphatidylinositol antibodies in plasma of female rats during the appearance of DMBA-induced malignant mammary tumors</title><author>Faiderbe, S. ; Chagnaud, J.-L. ; Diolez-Bojda, F. ; Kerdélhué, B. ; Geffard, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-1e545cd6d74905c1c1919a6f228977a1512a3f53b51f94c0255da53025a23b193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene</topic><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Antibody Affinity</topic><topic>Antibody Specificity</topic><topic>Autoantibodies - analysis</topic><topic>autoantibody</topic><topic>avidity</topic><topic>Biological and medical sciences</topic><topic>DMBA</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Experimental genital and mammary tumors</topic><topic>Female</topic><topic>Mammary Neoplasms, Experimental - chemically induced</topic><topic>Mammary Neoplasms, Experimental - immunology</topic><topic>mammary tumor</topic><topic>Medical sciences</topic><topic>phosphatidylinositol</topic><topic>Phosphatidylinositols - immunology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reference Values</topic><topic>specificity</topic><topic>Time Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faiderbe, S.</creatorcontrib><creatorcontrib>Chagnaud, J.-L.</creatorcontrib><creatorcontrib>Diolez-Bojda, F.</creatorcontrib><creatorcontrib>Kerdélhué, B.</creatorcontrib><creatorcontrib>Geffard, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faiderbe, S.</au><au>Chagnaud, J.-L.</au><au>Diolez-Bojda, F.</au><au>Kerdélhué, B.</au><au>Geffard, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increase of auto anti-phosphatidylinositol antibodies in plasma of female rats during the appearance of DMBA-induced malignant mammary tumors</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1991-04-01</date><risdate>1991</risdate><volume>57</volume><issue>1</issue><spage>15</spage><epage>19</epage><pages>15-19</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>Using a lipid-adapted ELISA, antiphosphatidylinositol (PtdIns) antibodies (Ab) have been found in sera of cancer patients. With the same procedure, we have checked their possible raising in plasma of female rats during the appearance of 7,12-dimethylbenz[
a]anthracene (DMBA)-induced mammary tumors. Twenty days after DMBA administration, the mean anti-PtdIns Ab level was already higher than that of control rats (oil). Immunochemical analysis of the anti-PtdIns Ab site showed a rather high Ab avidity (8 × 10
−9 M, at half-displacement) and high specificity for glyceryl phosphate inositol residues. Other phospholipids (PL) were not recognized by the anti-PtdIns Ab induced by malignant cell transformation.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1902757</pmid><doi>10.1016/0304-3835(91)90057-O</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1991-04, Vol.57 (1), p.15-19 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 9,10-Dimethyl-1,2-benzanthracene Animal tumors. Experimental tumors Animals Antibody Affinity Antibody Specificity Autoantibodies - analysis autoantibody avidity Biological and medical sciences DMBA Enzyme-Linked Immunosorbent Assay Experimental genital and mammary tumors Female Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - immunology mammary tumor Medical sciences phosphatidylinositol Phosphatidylinositols - immunology Rats Rats, Inbred Strains Reference Values specificity Time Factors Tumors |
| title | Increase of auto anti-phosphatidylinositol antibodies in plasma of female rats during the appearance of DMBA-induced malignant mammary tumors |
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