Inhibition of 12- O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation by natural colorants
Natural colorants such as anthocyanins, betalains, carotenoids, curcuminoids and chlorophylls have been widely used in the food processing industry and in beverages. Most of these colorants constitute part of human dietary components and are considered to be harmless and non-toxic. As a part of the...
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| Veröffentlicht in: | Cancer letters 1997-05, Vol.115 (2), p.173-178 |
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| creator | Kapadia, Govind J. Balasubramanian, Venkataraman Tokuda, Harukuni Iwashima, Akia Nishino, Hoyoku |
| description | Natural colorants such as anthocyanins, betalains, carotenoids, curcuminoids and chlorophylls have been widely used in the food processing industry and in beverages. Most of these colorants constitute part of human dietary components and are considered to be harmless and non-toxic. As a part of the study of natural products to identify non-toxic cancer chemopreventive agents, we have investigated several natural colorant extracts from vegetables and fruits of daily human consumption for their cancer chemopreventive action using the short-term in vitro assay which involves inhibition of Epstein-Barr virus early antigen activation (EBV-EA) induced by phorbol esters. Our study has identified several plant extracts that show profound activity in the EBA assay. |
| doi_str_mv | 10.1016/S0304-3835(97)04726-5 |
| format | Article |
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Balasubramanian, Venkataraman ; Tokuda, Harukuni ; Iwashima, Akia ; Nishino, Hoyoku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-a892b8aeda8be58d49a1b59848ef376ab8f4686a8a41c97e17cf08159f17d4453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Anticarcinogenic Agents - pharmacology</topic><topic>Antigen</topic><topic>Antigens, Viral - drug effects</topic><topic>Antigens, Viral - physiology</topic><topic>Carcinogens - pharmacology</topic><topic>Cell Survival - drug effects</topic><topic>Chemoprevention</topic><topic>Epstein-Barr virus</topic><topic>Food Coloring Agents - pharmacology</topic><topic>Fruit - chemistry</topic><topic>Herpesvirus 4, Human - drug effects</topic><topic>Herpesvirus 4, Human - growth & development</topic><topic>Herpesvirus 4, Human - immunology</topic><topic>Humans</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - virology</topic><topic>Natural colorants</topic><topic>Plant Extracts - pharmacology</topic><topic>Tetradecanoylphorbol Acetate - antagonists & inhibitors</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>Vegetables - chemistry</topic><topic>Virus Activation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kapadia, Govind J.</creatorcontrib><creatorcontrib>Balasubramanian, Venkataraman</creatorcontrib><creatorcontrib>Tokuda, Harukuni</creatorcontrib><creatorcontrib>Iwashima, Akia</creatorcontrib><creatorcontrib>Nishino, Hoyoku</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kapadia, Govind J.</au><au>Balasubramanian, Venkataraman</au><au>Tokuda, Harukuni</au><au>Iwashima, Akia</au><au>Nishino, Hoyoku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of 12- O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation by natural colorants</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1997-05-19</date><risdate>1997</risdate><volume>115</volume><issue>2</issue><spage>173</spage><epage>178</epage><pages>173-178</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Natural colorants such as anthocyanins, betalains, carotenoids, curcuminoids and chlorophylls have been widely used in the food processing industry and in beverages. Most of these colorants constitute part of human dietary components and are considered to be harmless and non-toxic. As a part of the study of natural products to identify non-toxic cancer chemopreventive agents, we have investigated several natural colorant extracts from vegetables and fruits of daily human consumption for their cancer chemopreventive action using the short-term in vitro assay which involves inhibition of Epstein-Barr virus early antigen activation (EBV-EA) induced by phorbol esters. Our study has identified several plant extracts that show profound activity in the EBA assay.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>9149121</pmid><doi>10.1016/S0304-3835(97)04726-5</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cancer letters, 1997-05, Vol.115 (2), p.173-178 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Anticarcinogenic Agents - pharmacology Antigen Antigens, Viral - drug effects Antigens, Viral - physiology Carcinogens - pharmacology Cell Survival - drug effects Chemoprevention Epstein-Barr virus Food Coloring Agents - pharmacology Fruit - chemistry Herpesvirus 4, Human - drug effects Herpesvirus 4, Human - growth & development Herpesvirus 4, Human - immunology Humans Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - virology Natural colorants Plant Extracts - pharmacology Tetradecanoylphorbol Acetate - antagonists & inhibitors Tetradecanoylphorbol Acetate - pharmacology Vegetables - chemistry Virus Activation - drug effects |
| title | Inhibition of 12- O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation by natural colorants |
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