Induction of a cytotoxic T lymphocyte response by immunization with a malaria specific CTL peptide entrapped in biodegradable polymer microspheres
We have previously reported that biodegradable polymer microspheres (MS) are capable of eliciting strong and long-lasting antibody and T cell proliferative responses for either natural protein antigens or synthetic peptides. In this study, we investigated the possibility of inducing antigen-specific...
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| Veröffentlicht in: | Vaccine 1997-08, Vol.15 (12), p.1405-1412 |
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| container_title | Vaccine |
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| creator | Men, Ying Tamber, Harjit Audran, Régine Gander, Bruno Corradin, Giampietro |
| description | We have previously reported that biodegradable polymer microspheres (MS) are capable of eliciting strong and long-lasting antibody and T cell proliferative responses for either natural protein antigens or synthetic peptides. In this study, we investigated the possibility of inducing antigen-specific cytotoxic T lymphocyte (CTL) responses
in vivo with a short synthetic peptide from the circumsporozoite (CS) protein of
Plasmodium berghei (Pb) 252–260 by using different MS formulations. We show that injection of mice with a short CTL epitope microencapsulated in MS or adsorbed on empty MS enhanced a specific CTL response comparable to that obtained with the incomplete Freund's adjuvant (IFA) formulation, indicating that MS are a potent antigen delivery system/immunostimulant for CTL response. These results might be of practical interest for MS preparation and development of subunit vaccines. |
| doi_str_mv | 10.1016/S0264-410X(97)00047-9 |
| format | Article |
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in vivo with a short synthetic peptide from the circumsporozoite (CS) protein of
Plasmodium berghei (Pb) 252–260 by using different MS formulations. We show that injection of mice with a short CTL epitope microencapsulated in MS or adsorbed on empty MS enhanced a specific CTL response comparable to that obtained with the incomplete Freund's adjuvant (IFA) formulation, indicating that MS are a potent antigen delivery system/immunostimulant for CTL response. These results might be of practical interest for MS preparation and development of subunit vaccines.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(97)00047-9</identifier><identifier>PMID: 9302752</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antigens, Protozoan - immunology ; Applied microbiology ; biodegradable microspheres ; Biodegradation, Environmental ; Biological and medical sciences ; CTL response ; Female ; Fundamental and applied biological sciences. Psychology ; Immunization ; malaria vaccine ; Malaria Vaccines - immunology ; Mice ; Mice, Inbred BALB C ; Microbiology ; Microspheres ; peptide ; Plasmodium berghei ; Protozoan Proteins - administration & dosage ; Protozoan Proteins - immunology ; T-Lymphocytes, Cytotoxic - immunology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 1997-08, Vol.15 (12), p.1405-1412</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-21baa2c56a699e6dfb0bea113a3c4a2a4b48017e618b0f6790801e2c896cc0dd3</citedby><cites>FETCH-LOGICAL-c420t-21baa2c56a699e6dfb0bea113a3c4a2a4b48017e618b0f6790801e2c896cc0dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0264-410X(97)00047-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2812990$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9302752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Men, Ying</creatorcontrib><creatorcontrib>Tamber, Harjit</creatorcontrib><creatorcontrib>Audran, Régine</creatorcontrib><creatorcontrib>Gander, Bruno</creatorcontrib><creatorcontrib>Corradin, Giampietro</creatorcontrib><title>Induction of a cytotoxic T lymphocyte response by immunization with a malaria specific CTL peptide entrapped in biodegradable polymer microspheres</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>We have previously reported that biodegradable polymer microspheres (MS) are capable of eliciting strong and long-lasting antibody and T cell proliferative responses for either natural protein antigens or synthetic peptides. In this study, we investigated the possibility of inducing antigen-specific cytotoxic T lymphocyte (CTL) responses
in vivo with a short synthetic peptide from the circumsporozoite (CS) protein of
Plasmodium berghei (Pb) 252–260 by using different MS formulations. We show that injection of mice with a short CTL epitope microencapsulated in MS or adsorbed on empty MS enhanced a specific CTL response comparable to that obtained with the incomplete Freund's adjuvant (IFA) formulation, indicating that MS are a potent antigen delivery system/immunostimulant for CTL response. These results might be of practical interest for MS preparation and development of subunit vaccines.</description><subject>Animals</subject><subject>Antigens, Protozoan - immunology</subject><subject>Applied microbiology</subject><subject>biodegradable microspheres</subject><subject>Biodegradation, Environmental</subject><subject>Biological and medical sciences</subject><subject>CTL response</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunization</subject><subject>malaria vaccine</subject><subject>Malaria Vaccines - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Microspheres</subject><subject>peptide</subject><subject>Plasmodium berghei</subject><subject>Protozoan Proteins - administration & dosage</subject><subject>Protozoan Proteins - immunology</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEUhYMoYzv6CANZiDiL0iT1k8pKhsbRgQYXtuAu3Epu2ZGqSkyq1PYxfGLTP_TWVUjud3Iu5xByw9kbznjz9jMTTVVUnH19reQtY6yShXpEVryVZSFq3j4mqwvylDxL6XuG6pKrK3KlSiZkLVbk78NkFzM7P1HfU6BmP_vZ_3aGbumwH8PO5xekEVPwU0La7akbx2Vyf-Ao-uXmXZaNMEB0QFNA4_qsXm83NGCYnUWK0xwhBLTUTbRz3uK3CBa6AWnw2QQjHZ2JPoUdZqPn5EkPQ8IX5_OafLl_v11_LDafPjys7zaFqQSbC8E7AGHqBhqlsLF9xzoEzksoTQUCqq5qGZfY8LZjfSMVy1cUplWNMcza8pq8Ov0bov-xYJr16JLBYYAJ_ZI0b1grhawyWJ_Aw44pYq9DdCPEveZMH7rQxy70IWitpD52oVXW3ZwNlm5Ee1Gdw8_zl-c5JANDH2EyLl0w0XKhFMvYuxOGOYyfDqNOxuFk0LqIZtbWu_8s8g8QB6ms</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Men, Ying</creator><creator>Tamber, Harjit</creator><creator>Audran, Régine</creator><creator>Gander, Bruno</creator><creator>Corradin, Giampietro</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>19970801</creationdate><title>Induction of a cytotoxic T lymphocyte response by immunization with a malaria specific CTL peptide entrapped in biodegradable polymer microspheres</title><author>Men, Ying ; Tamber, Harjit ; Audran, Régine ; Gander, Bruno ; Corradin, Giampietro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-21baa2c56a699e6dfb0bea113a3c4a2a4b48017e618b0f6790801e2c896cc0dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Antigens, Protozoan - immunology</topic><topic>Applied microbiology</topic><topic>biodegradable microspheres</topic><topic>Biodegradation, Environmental</topic><topic>Biological and medical sciences</topic><topic>CTL response</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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In this study, we investigated the possibility of inducing antigen-specific cytotoxic T lymphocyte (CTL) responses
in vivo with a short synthetic peptide from the circumsporozoite (CS) protein of
Plasmodium berghei (Pb) 252–260 by using different MS formulations. We show that injection of mice with a short CTL epitope microencapsulated in MS or adsorbed on empty MS enhanced a specific CTL response comparable to that obtained with the incomplete Freund's adjuvant (IFA) formulation, indicating that MS are a potent antigen delivery system/immunostimulant for CTL response. These results might be of practical interest for MS preparation and development of subunit vaccines.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9302752</pmid><doi>10.1016/S0264-410X(97)00047-9</doi><tpages>8</tpages></addata></record> |
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| ispartof | Vaccine, 1997-08, Vol.15 (12), p.1405-1412 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antigens, Protozoan - immunology Applied microbiology biodegradable microspheres Biodegradation, Environmental Biological and medical sciences CTL response Female Fundamental and applied biological sciences. Psychology Immunization malaria vaccine Malaria Vaccines - immunology Mice Mice, Inbred BALB C Microbiology Microspheres peptide Plasmodium berghei Protozoan Proteins - administration & dosage Protozoan Proteins - immunology T-Lymphocytes, Cytotoxic - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Induction of a cytotoxic T lymphocyte response by immunization with a malaria specific CTL peptide entrapped in biodegradable polymer microspheres |
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