"High single-dose' European PUVA regimen also causes an excess of non-melanoma skin cancer
Summary We report the results of a long‐term (12.8 Years) follow‐up study of the detection of malignnat and benign skin tumours in patients with psoriasis, who were treated with PUVA according to the European, ‘high sinle‐dose’ regimen. A total of 13 squamous cell carcinomas (SCC) and 24 basal cell...
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| Veröffentlicht in: | British journal of dermatology (1951) 1991-01, Vol.124 (1), p.49-55 |
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| container_title | British journal of dermatology (1951) |
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| creator | BRUYNZEEL, I. BERGMAN, W. HARTEVELT, H.M. KENTER, C.C.A. VAN DE VELDE, E.A. SCHOTHORST, A.A. SUURMOND, D. |
| description | Summary
We report the results of a long‐term (12.8 Years) follow‐up study of the detection of malignnat and benign skin tumours in patients with psoriasis, who were treated with PUVA according to the European, ‘high sinle‐dose’ regimen. A total of 13 squamous cell carcinomas (SCC) and 24 basal cell carcinomas (BCC) were diagnosed in 11 of 260 patients. The incidence of both SCC and BCC was increased in comparison with the general Dutch population. The ratio of SCC to BCC in the general population was 1:8 but was 1:2:5 in our study group. A positive correlation was observed between the development of SCC and the total UVA dosege, the age of the patient at the start of the PUVA treatment and a history of arsenic use. This dose‐realted increase in the incidence of SCC, reported in studies from the U.S.A., has not been found in earlier European studies. The average time period between the start of PUVA therapy and the diagnosis of the first malignant skin tumour was 6.0 years for SCC and 4.7 years for BCC. Among the 49 benign skin tumours were actinic keratoses, a kerato‐acanthoma and ‘PUVA keratoses’, a newly described hyperkeratotic lesion, especially found in PUVA‐treated patients. |
| doi_str_mv | 10.1111/j.1365-2133.1991.tb03281.x |
| format | Article |
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We report the results of a long‐term (12.8 Years) follow‐up study of the detection of malignnat and benign skin tumours in patients with psoriasis, who were treated with PUVA according to the European, ‘high sinle‐dose’ regimen. A total of 13 squamous cell carcinomas (SCC) and 24 basal cell carcinomas (BCC) were diagnosed in 11 of 260 patients. The incidence of both SCC and BCC was increased in comparison with the general Dutch population. The ratio of SCC to BCC in the general population was 1:8 but was 1:2:5 in our study group. A positive correlation was observed between the development of SCC and the total UVA dosege, the age of the patient at the start of the PUVA treatment and a history of arsenic use. This dose‐realted increase in the incidence of SCC, reported in studies from the U.S.A., has not been found in earlier European studies. The average time period between the start of PUVA therapy and the diagnosis of the first malignant skin tumour was 6.0 years for SCC and 4.7 years for BCC. Among the 49 benign skin tumours were actinic keratoses, a kerato‐acanthoma and ‘PUVA keratoses’, a newly described hyperkeratotic lesion, especially found in PUVA‐treated patients.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.1991.tb03281.x</identifier><identifier>PMID: 1993145</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Basal Cell - chemically induced ; Carcinoma, Basal Cell - epidemiology ; Carcinoma, Squamous Cell - chemically induced ; Carcinoma, Squamous Cell - epidemiology ; Diseases of the skin. Cosmetics ; Female ; Follow-Up Studies ; Humans ; Incidence ; Keratoacanthoma - chemically induced ; Keratoacanthoma - pathology ; Male ; Medical sciences ; Middle Aged ; Psoriasis - drug therapy ; PUVA Therapy - adverse effects ; PUVA Therapy - methods ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Skin - pathology ; Skin Neoplasms - chemically induced ; Skin Neoplasms - epidemiology</subject><ispartof>British journal of dermatology (1951), 1991-01, Vol.124 (1), p.49-55</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3829-9c678816b14da4d47c9f462f0fe360c8a5df3573c83ccc06562f1d49c3d49fef3</citedby><cites>FETCH-LOGICAL-c3829-9c678816b14da4d47c9f462f0fe360c8a5df3573c83ccc06562f1d49c3d49fef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.1991.tb03281.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.1991.tb03281.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19462551$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1993145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BRUYNZEEL, I.</creatorcontrib><creatorcontrib>BERGMAN, W.</creatorcontrib><creatorcontrib>HARTEVELT, H.M.</creatorcontrib><creatorcontrib>KENTER, C.C.A.</creatorcontrib><creatorcontrib>VAN DE VELDE, E.A.</creatorcontrib><creatorcontrib>SCHOTHORST, A.A.</creatorcontrib><creatorcontrib>SUURMOND, D.</creatorcontrib><title>"High single-dose' European PUVA regimen also causes an excess of non-melanoma skin cancer</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
We report the results of a long‐term (12.8 Years) follow‐up study of the detection of malignnat and benign skin tumours in patients with psoriasis, who were treated with PUVA according to the European, ‘high sinle‐dose’ regimen. A total of 13 squamous cell carcinomas (SCC) and 24 basal cell carcinomas (BCC) were diagnosed in 11 of 260 patients. The incidence of both SCC and BCC was increased in comparison with the general Dutch population. The ratio of SCC to BCC in the general population was 1:8 but was 1:2:5 in our study group. A positive correlation was observed between the development of SCC and the total UVA dosege, the age of the patient at the start of the PUVA treatment and a history of arsenic use. This dose‐realted increase in the incidence of SCC, reported in studies from the U.S.A., has not been found in earlier European studies. The average time period between the start of PUVA therapy and the diagnosis of the first malignant skin tumour was 6.0 years for SCC and 4.7 years for BCC. Among the 49 benign skin tumours were actinic keratoses, a kerato‐acanthoma and ‘PUVA keratoses’, a newly described hyperkeratotic lesion, especially found in PUVA‐treated patients.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Basal Cell - chemically induced</subject><subject>Carcinoma, Basal Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - chemically induced</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Diseases of the skin. Cosmetics</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Keratoacanthoma - chemically induced</subject><subject>Keratoacanthoma - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Psoriasis - drug therapy</subject><subject>PUVA Therapy - adverse effects</subject><subject>PUVA Therapy - methods</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Skin - pathology</subject><subject>Skin Neoplasms - chemically induced</subject><subject>Skin Neoplasms - epidemiology</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1u1DAUhS0EKkPLIyBZlYBVgh3_JEHqorSlQ1vxJwoSG8vjXA-eJvHUnojp2-Moo7ZbvLAX53z29YfQISU5TevdKqdMiqygjOW0rmm-WRBWVDTfPkGz--gpmhFCyozUkj1HL2JcEUIZEWQP7SWKUS5m6Pfh3C3_4Oj6ZQtZ4yO8xWdD8GvQPf56_fMYB1i6Dnqs2-ix0UOEiFMGWwMxYm9x7_usg1b3vtM43rg-tXoD4QA9swmCl7tzH11_PPtxMs-uvpx_Ojm-ygyrijqrjSyrisoF5Y3mDS9NbbksLLHAJDGVFo1lomSmYsYYIkXKaMNrw9JmwbJ99Ga6dx387QBxozoXDbRpIvBDVFSSivOSpuL7qWiCjzGAVevgOh3uFCVqFKtWarSnRntqFKt2YtU2wa92rwyLDpoHdDKZ8te7XEejWxuSAxcf1dKfhBiHOJp6f10Ld_8xgfpwccrrxGcT7-IGtve8DjdKlqwU6tfnc3XJv5HL4rtQc_YPSOajHA</recordid><startdate>199101</startdate><enddate>199101</enddate><creator>BRUYNZEEL, I.</creator><creator>BERGMAN, W.</creator><creator>HARTEVELT, H.M.</creator><creator>KENTER, C.C.A.</creator><creator>VAN DE VELDE, E.A.</creator><creator>SCHOTHORST, A.A.</creator><creator>SUURMOND, D.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>199101</creationdate><title>"High single-dose' European PUVA regimen also causes an excess of non-melanoma skin cancer</title><author>BRUYNZEEL, I. ; BERGMAN, W. ; HARTEVELT, H.M. ; KENTER, C.C.A. ; VAN DE VELDE, E.A. ; SCHOTHORST, A.A. ; SUURMOND, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3829-9c678816b14da4d47c9f462f0fe360c8a5df3573c83ccc06562f1d49c3d49fef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Basal Cell - chemically induced</topic><topic>Carcinoma, Basal Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - chemically induced</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Diseases of the skin. Cosmetics</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Keratoacanthoma - chemically induced</topic><topic>Keratoacanthoma - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Psoriasis - drug therapy</topic><topic>PUVA Therapy - adverse effects</topic><topic>PUVA Therapy - methods</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Skin - pathology</topic><topic>Skin Neoplasms - chemically induced</topic><topic>Skin Neoplasms - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BRUYNZEEL, I.</creatorcontrib><creatorcontrib>BERGMAN, W.</creatorcontrib><creatorcontrib>HARTEVELT, H.M.</creatorcontrib><creatorcontrib>KENTER, C.C.A.</creatorcontrib><creatorcontrib>VAN DE VELDE, E.A.</creatorcontrib><creatorcontrib>SCHOTHORST, A.A.</creatorcontrib><creatorcontrib>SUURMOND, D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BRUYNZEEL, I.</au><au>BERGMAN, W.</au><au>HARTEVELT, H.M.</au><au>KENTER, C.C.A.</au><au>VAN DE VELDE, E.A.</au><au>SCHOTHORST, A.A.</au><au>SUURMOND, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>"High single-dose' European PUVA regimen also causes an excess of non-melanoma skin cancer</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>1991-01</date><risdate>1991</risdate><volume>124</volume><issue>1</issue><spage>49</spage><epage>55</epage><pages>49-55</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
We report the results of a long‐term (12.8 Years) follow‐up study of the detection of malignnat and benign skin tumours in patients with psoriasis, who were treated with PUVA according to the European, ‘high sinle‐dose’ regimen. A total of 13 squamous cell carcinomas (SCC) and 24 basal cell carcinomas (BCC) were diagnosed in 11 of 260 patients. The incidence of both SCC and BCC was increased in comparison with the general Dutch population. The ratio of SCC to BCC in the general population was 1:8 but was 1:2:5 in our study group. A positive correlation was observed between the development of SCC and the total UVA dosege, the age of the patient at the start of the PUVA treatment and a history of arsenic use. This dose‐realted increase in the incidence of SCC, reported in studies from the U.S.A., has not been found in earlier European studies. The average time period between the start of PUVA therapy and the diagnosis of the first malignant skin tumour was 6.0 years for SCC and 4.7 years for BCC. Among the 49 benign skin tumours were actinic keratoses, a kerato‐acanthoma and ‘PUVA keratoses’, a newly described hyperkeratotic lesion, especially found in PUVA‐treated patients.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1993145</pmid><doi>10.1111/j.1365-2133.1991.tb03281.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over Biological and medical sciences Carcinoma, Basal Cell - chemically induced Carcinoma, Basal Cell - epidemiology Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - epidemiology Diseases of the skin. Cosmetics Female Follow-Up Studies Humans Incidence Keratoacanthoma - chemically induced Keratoacanthoma - pathology Male Medical sciences Middle Aged Psoriasis - drug therapy PUVA Therapy - adverse effects PUVA Therapy - methods Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Skin - pathology Skin Neoplasms - chemically induced Skin Neoplasms - epidemiology |
| title | "High single-dose' European PUVA regimen also causes an excess of non-melanoma skin cancer |
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