21‐Aminosteroids Interact with the Dopamine Transporter to Protect Against 1‐Methyl‐4‐Phenylpyridinium‐Induced Neurotoxicity

: U‐78518F, a 21‐aminosteroid from the novel family of lipid peroxidation inhibitors (lazaroids), increased survival of dopamine (DA) neurons in mesencephalic cell cultures incubated with the neurotoxin l‐methyl‐4‐phenylpyridinium (MPP+). Protection against DA neuron death occurred with increasing c...

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Veröffentlicht in:	Journal of neurochemistry 1992-01, Vol.58 (1), p.328-334
Hauptverfasser:	Sanchez‐Ramos, Juan R., Song, Shije, Mash, Deborah C., Weiner, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenylpyridinium - antagonists & inhibitors 21‐Aminosteroids Animals Binding, Competitive Carrier Proteins - physiology Corpus Striatum - metabolism Dopamine - pharmacokinetics Dopamine Plasma Membrane Transport Proteins Dopamine transporter Drug Interactions Ethylamines - pharmacology Membrane Glycoproteins Membrane Transport Proteins Mesencephalic cell cultures MPP Nerve Tissue Proteins - physiology Neurons - metabolism Neurons - physiology Neurotoxicity Neurotoxins - antagonists & inhibitors Piperazines - pharmacology Pyridines - pharmacology Steroids - chemistry Steroids - pharmacology
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