Effect of selenium on plasma glucose of rats: role of insulin and glucocorticoids
The effects of acute treatment (i.p.) of selenium (Se) on glucoregulation and on plasma levels of glucose, insulin and corticosterone were determined in both fed and 24-hour-fasted rats. In this experiment animals were treated with saline (control) or 1.3,1.6 and 3.8 mg/kg doses of Se. Blood samples...
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| Veröffentlicht in: | Toxicology letters 1991-10, Vol.58 (2), p.199-207 |
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| creator | Rasekh, Hamid R. Potmis, Ronaldo A. Nonavinakere, Vani K. Early, Johnnie L. Iszard, Marcus B. |
| description | The effects of acute treatment (i.p.) of selenium (Se) on glucoregulation and on plasma levels of glucose, insulin and corticosterone were determined in both fed and 24-hour-fasted rats. In this experiment animals were treated with saline (control) or 1.3,1.6 and 3.8 mg/kg doses of Se. Blood samples were collected before, 30, 60 and 90 min following injection. The results obtained show that acute intraperitoneal (i.p.) administration of Se (
i1.6 mg/kg or more) causes hyperglycemia in rats. It was found that Se does not change levels of plasma insulin in either fasted or fed animals. Se did, however, significantly increase the plasma levels of corticosterone in all Se-treated groups. In order to confirm the role of corticosterone and thus support the significance of adrenal glands in this hyperglycemic response, animals were subjected to bilateral adrenalectomy. Blood samples were collected before, 30, 60 and 90 min following intraperitoneal treatment with Se. The results indicate that bilateral adrenalectomy abolishes the hyperglycemic response to Se. It can be concluded that adrenal glands play a role in Se-induced hyperglycemia. The increase in corticosterone levels suggest the possibility of gluconeogenesis in contributing to this hyperglycemic response. |
| doi_str_mv | 10.1016/0378-4274(91)90174-5 |
| format | Article |
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i1.6 mg/kg or more) causes hyperglycemia in rats. It was found that Se does not change levels of plasma insulin in either fasted or fed animals. Se did, however, significantly increase the plasma levels of corticosterone in all Se-treated groups. In order to confirm the role of corticosterone and thus support the significance of adrenal glands in this hyperglycemic response, animals were subjected to bilateral adrenalectomy. Blood samples were collected before, 30, 60 and 90 min following intraperitoneal treatment with Se. The results indicate that bilateral adrenalectomy abolishes the hyperglycemic response to Se. It can be concluded that adrenal glands play a role in Se-induced hyperglycemia. The increase in corticosterone levels suggest the possibility of gluconeogenesis in contributing to this hyperglycemic response.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/0378-4274(91)90174-5</identifier><identifier>PMID: 1949078</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adrenal glands ; Animals ; Biological and medical sciences ; Blood Glucose - metabolism ; Carbohydrates ; Corticosterone ; Fasting - blood ; Fundamental and applied biological sciences. Psychology ; Glucocorticoids - physiology ; Hyperglycemia ; Hyperglycemia - chemically induced ; Insulin ; Insulin - physiology ; Male ; Metabolisms and neurohumoral controls ; Rats ; Rats, Inbred Strains ; Selenium ; Selenium - pharmacology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Toxicology letters, 1991-10, Vol.58 (2), p.199-207</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-4961b4be258bc2f3c3b03ad62f59bc221586563378f2ab1c3038d4a54b5562453</citedby><cites>FETCH-LOGICAL-c483t-4961b4be258bc2f3c3b03ad62f59bc221586563378f2ab1c3038d4a54b5562453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-4274(91)90174-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5005028$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1949078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasekh, Hamid R.</creatorcontrib><creatorcontrib>Potmis, Ronaldo A.</creatorcontrib><creatorcontrib>Nonavinakere, Vani K.</creatorcontrib><creatorcontrib>Early, Johnnie L.</creatorcontrib><creatorcontrib>Iszard, Marcus B.</creatorcontrib><title>Effect of selenium on plasma glucose of rats: role of insulin and glucocorticoids</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>The effects of acute treatment (i.p.) of selenium (Se) on glucoregulation and on plasma levels of glucose, insulin and corticosterone were determined in both fed and 24-hour-fasted rats. In this experiment animals were treated with saline (control) or 1.3,1.6 and 3.8 mg/kg doses of Se. Blood samples were collected before, 30, 60 and 90 min following injection. The results obtained show that acute intraperitoneal (i.p.) administration of Se (
i1.6 mg/kg or more) causes hyperglycemia in rats. It was found that Se does not change levels of plasma insulin in either fasted or fed animals. Se did, however, significantly increase the plasma levels of corticosterone in all Se-treated groups. In order to confirm the role of corticosterone and thus support the significance of adrenal glands in this hyperglycemic response, animals were subjected to bilateral adrenalectomy. Blood samples were collected before, 30, 60 and 90 min following intraperitoneal treatment with Se. The results indicate that bilateral adrenalectomy abolishes the hyperglycemic response to Se. It can be concluded that adrenal glands play a role in Se-induced hyperglycemia. The increase in corticosterone levels suggest the possibility of gluconeogenesis in contributing to this hyperglycemic response.</description><subject>Adrenal glands</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Carbohydrates</subject><subject>Corticosterone</subject><subject>Fasting - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucocorticoids - physiology</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - chemically induced</subject><subject>Insulin</subject><subject>Insulin - physiology</subject><subject>Male</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Selenium</subject><subject>Selenium - pharmacology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1q3DAURkVJmUwmfYMGvAghWTjVv60sAiEkbSBQCulayLJUVGRromsH8va1x8Nk15W4-s79kA5CXwm-JpjIb5hVdclpxS8VuVKYVLwUn9Ca1JUqGZHqCK0PyDE6AfiLMZZcihVaEcUVruo1-vXgvbNDkXwBLro-jF2R-mIbDXSm-BNHm8DNaTYD3BQ5xd0Uehhj6AvTtwtkUx6CTaGFU_TZmwjuy_7coN-PDy_3P8rnn9-f7u-eS8trNpRcSdLwxlFRN5Z6ZlmDmWkl9UJNF5SIWgrJpg94ahpiGWZ1y43gjRCScsE26GLp3eb0OjoYdBfAuhhN79IImkhcU6HkBPIFtDkBZOf1NofO5HdNsJ5N6lmTnjVpRfTOpJ77z_b9Y9O59mNpUTfl5_vcgDXRZ9PbAAdMYCwwnbHbBXOTi7fgsgYbXG9dG_IkXrcp_P8d_wDV_Y4c</recordid><startdate>19911001</startdate><enddate>19911001</enddate><creator>Rasekh, Hamid R.</creator><creator>Potmis, Ronaldo A.</creator><creator>Nonavinakere, Vani K.</creator><creator>Early, Johnnie L.</creator><creator>Iszard, Marcus B.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19911001</creationdate><title>Effect of selenium on plasma glucose of rats: role of insulin and glucocorticoids</title><author>Rasekh, Hamid R. ; Potmis, Ronaldo A. ; Nonavinakere, Vani K. ; Early, Johnnie L. ; Iszard, Marcus B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-4961b4be258bc2f3c3b03ad62f59bc221586563378f2ab1c3038d4a54b5562453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adrenal glands</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Carbohydrates</topic><topic>Corticosterone</topic><topic>Fasting - blood</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucocorticoids - physiology</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - chemically induced</topic><topic>Insulin</topic><topic>Insulin - physiology</topic><topic>Male</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Selenium</topic><topic>Selenium - pharmacology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rasekh, Hamid R.</creatorcontrib><creatorcontrib>Potmis, Ronaldo A.</creatorcontrib><creatorcontrib>Nonavinakere, Vani K.</creatorcontrib><creatorcontrib>Early, Johnnie L.</creatorcontrib><creatorcontrib>Iszard, Marcus B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rasekh, Hamid R.</au><au>Potmis, Ronaldo A.</au><au>Nonavinakere, Vani K.</au><au>Early, Johnnie L.</au><au>Iszard, Marcus B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of selenium on plasma glucose of rats: role of insulin and glucocorticoids</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>1991-10-01</date><risdate>1991</risdate><volume>58</volume><issue>2</issue><spage>199</spage><epage>207</epage><pages>199-207</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>The effects of acute treatment (i.p.) of selenium (Se) on glucoregulation and on plasma levels of glucose, insulin and corticosterone were determined in both fed and 24-hour-fasted rats. In this experiment animals were treated with saline (control) or 1.3,1.6 and 3.8 mg/kg doses of Se. Blood samples were collected before, 30, 60 and 90 min following injection. The results obtained show that acute intraperitoneal (i.p.) administration of Se (
i1.6 mg/kg or more) causes hyperglycemia in rats. It was found that Se does not change levels of plasma insulin in either fasted or fed animals. Se did, however, significantly increase the plasma levels of corticosterone in all Se-treated groups. In order to confirm the role of corticosterone and thus support the significance of adrenal glands in this hyperglycemic response, animals were subjected to bilateral adrenalectomy. Blood samples were collected before, 30, 60 and 90 min following intraperitoneal treatment with Se. The results indicate that bilateral adrenalectomy abolishes the hyperglycemic response to Se. It can be concluded that adrenal glands play a role in Se-induced hyperglycemia. The increase in corticosterone levels suggest the possibility of gluconeogenesis in contributing to this hyperglycemic response.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>1949078</pmid><doi>10.1016/0378-4274(91)90174-5</doi><tpages>9</tpages></addata></record> |
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| ispartof | Toxicology letters, 1991-10, Vol.58 (2), p.199-207 |
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| subjects | Adrenal glands Animals Biological and medical sciences Blood Glucose - metabolism Carbohydrates Corticosterone Fasting - blood Fundamental and applied biological sciences. Psychology Glucocorticoids - physiology Hyperglycemia Hyperglycemia - chemically induced Insulin Insulin - physiology Male Metabolisms and neurohumoral controls Rats Rats, Inbred Strains Selenium Selenium - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effect of selenium on plasma glucose of rats: role of insulin and glucocorticoids |
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