HLA class II-induced translocation of PKC alpha and PKC beta II isoforms is abrogated following truncation of DR beta cytoplasmic domains

Several studies have attempted to identify regions of the MHC class II molecule that participate in signal transduction. The importance of intact murine I-A cytoplasmic domains, either to tether the class II molecule to the cytoskeleton or to recruit signal-transducing proteins, is now well establis...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-10, Vol.159 (8), p.3792-3798
Hauptverfasser:	Rich, T, Lawler, SE, Lord, JM, Blancheteau, VM, Charron, DJ, Mooney, NA
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies, Monoclonal - chemistry Antigens, Differentiation, B-Lymphocyte - genetics Biological Transport Cell Line, Transformed Cell Membrane - immunology Cell Membrane - metabolism Cytoplasm - chemistry Cytoplasm - metabolism Enzyme Activation - genetics Enzyme Activation - immunology Epitopes - chemistry Histocompatibility Antigens Class II - genetics HLA-DR Antigens - biosynthesis HLA-DR Antigens - chemistry HLA-DR Antigens - genetics HLA-DR Antigens - immunology Humans Isoenzymes - metabolism Kidney - cytology Molecular Sequence Data Mutagenesis, Site-Directed Protein Conformation Protein Kinase C - metabolism Protein Kinase C beta Protein Kinase C-alpha Protein Structure, Tertiary Protein-Tyrosine Kinases - immunology Protein-Tyrosine Kinases - metabolism Transfection - immunology
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