An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol

Experiments were performed with mice to determine whether doses of the benzodiazepine, flurazepam, or the GABA uptake inhibitor, NO-328, known to potentiate catalepsy induced by delta-9-tetrahydrocannabinol (THC), would also interact synergistically with THC in the production of certain other effect...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1991-11, Vol.40 (3), p.581-585
Hauptverfasser:	Pertwee, R.G., Browne, S.E., Ross, T.M., Stretton, C.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - pharmacology Amino Acids, Neutral Analgesics - pharmacology Animals Anticonvulsant effect Anticonvulsants - pharmacology Antinociception Benzodiazepine Biological and medical sciences Body temperature Body Temperature - drug effects Cannabidiol Cannabidiol - pharmacology Delta-9-THC Dronabinol - pharmacology Drug addictions Electric Stimulation Flurazepam Flurazepam - pharmacology Gamma-aminobutyric acid gamma-Aminobutyric Acid - physiology Guinea pig isolated ileum Guinea Pigs Hypothermia In Vitro Techniques Male Medical sciences Mice Muscle Contraction - drug effects Muscle, Smooth - drug effects Nipecotic Acids - pharmacology Pentylenetetrazole Seizures - chemically induced Seizures - prevention & control Tiagabine Toxicology
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