Hemodynamic and electrophysiological actions of cocaine : effects of sodium bicarbonate as an antidote in dogs

Cocaine abuse has been implicated as a cause of death due to sudden cardiac arrest. We examined the hemodynamic and electrophysiological effects of cocaine administered as a series of 5-mg/kg i.v. boluses coupled with a continuous infusion in anesthetized dogs. Sodium bicarbonate (50 meq i.v.) was a...

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